A self-assembling bioactive oligopeptide hydrogel for the treatment of edema following prepuce surgery

doi:10.1039/d4tb01456a

科研成果详情

题名	A self-assembling bioactive oligopeptide hydrogel for the treatment of edema following prepuce surgery
作者	Liu, Jianyong1; Pei, Yu3; Huang, Yingying 4; Jiang, Haofei1; Tadoh, Mike Pleass Tita 1; Huang, Xixi1; Shen, Jintao1; Zeng, Xiaoxi 5; Zheng, Bin 6; Pan, Jingye1; Yang, Guoqiang 1,2; Jiang, Haihong1; Chen, Limin1,2; Zhou, Yunlong1,2
发表日期	2024-08-19
发表期刊	JOURNAL OF MATERIALS CHEMISTRY B 影响因子和分区
语种	英语
原始文献类型	Article ; Early Access
关键词	Medicinal chemistry Bioactives Clinical application Clinical complications Clinical practices Effective solution Functionals Oligopeptides Self-assembling Single components Tri-peptides
其他关键词	CELLS
摘要	Edema of the prepuce is a common clinical complication following circumcision in urology. Nevertheless, the principal method of gauze wrapping in clinical practice has not yet been demonstrated to be an effective solution to the problem of postoperative edema. It is therefore evident that the development of functional dressings for the treatment of post-circumcision edema has considerable potential for both clinical application and translational significance. The objective of this study was to develop a single-component bioactive oligopeptide hydrogel dressing with favorable anti-inflammatory, pro-angiogenesis properties and biosafety for the treatment of edema following prepuce surgery. A hexapeptide (Ac-FFFGHK-OH) hydrogelator was designed and synthesized through the N-terminal modification of a human-derived glycine-histidine-lysine tripeptide (GHK) with an N-acetylated phenylalanine tripeptide (Ac-FFF). The bioactive Ac-FFFGHK-OH hydrogel can be prepared through a facile self-assembly method. Furthermore, a novel experimental animal model of post-circumcision edema in Sprague-Dawley rats was constructed and the in vivo anti-edema effect of the Ac-FFFGHK-OH hydrogel was confirmed. The mechanism of action in relieving edema was also investigated by in vitro cell experiments. This work may inspire alternative thinking for the development of mono-component bioactive oligopeptide hydrogels for the treatment of edema in various diseases. A mono-component chiral nanofiber hydrogel dressing was developed through self-assembly of bioactive oligopeptide (Ac-FFFGHK-OH) to effectively treat edema following prepuce surgery.
资助项目	National Natural Science Foundation of China [21773172, 21603166, 21573162, WIUCASQD2019001, WIUCASQD2024003, 2023C03084]; Research Center of Clinical Functional Materials and Diagnosis & Treatment Devices of Zhejiang Province [WIBEK181006]; Major Science and Technology Project of Wenzhou Science and Technology [ZG2022017]; Wenzhou High-Level Innovation Team (Development and application team of functional liver cancer-on-a-chip)
出版者	ROYAL SOC CHEMISTRY
ISSN	2050-750X
EISSN	2050-7518
卷号	12 期号:37 页码:9357-9363
DOI	10.1039/d4tb01456a
页数	7
WOS类目	Materials Science, Biomaterials
WOS研究方向	Materials Science
WOS记录号	WOS:001296069700001
收录类别	SCIE ; PUBMED ; EI
EI入藏号	20243516941386
EI主题词	Surgery
EI分类号	102.1 ; 102.1.2.1 ; 801.1 Chemistry, General
URL	查看原文
PubMed ID	39175412
通讯作者地址	[Yang, Guoqiang;Jiang, Haihong;Chen, Limin]Wenzhou Med Univ, Affiliated Hosp 1, Joint Ctr Translat Med, Wenzhou 325000, Peoples R China. ; [Yang, Guoqiang;Chen, Limin]Univ Chinese Acad Sci, Wenzhou Inst, Joint Ctr Translat Med, Wenzhou 325001, Peoples R China.
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/217351
专题	附属第一医院眼视光学院（生物医学工程学院）、附属眼视光医院
通讯作者	Yang, Guoqiang; Jiang, Haihong; Chen, Limin
作者单位	1.Wenzhou Med Univ, Affiliated Hosp 1, Joint Ctr Translat Med, Wenzhou 325000, Peoples R China; 2.Univ Chinese Acad Sci, Wenzhou Inst, Joint Ctr Translat Med, Wenzhou 325001, Peoples R China; 3.Wenzhou Med Univ, Eye Hosp, Sch Ophthalmol & Optometry, Sch Biomed Engn, Wenzhou 325000, Peoples R China; 4.Zhejiang Chinese Med Univ, Coll Pharmaceut Sci, Hangzhou 310053, Peoples R China; 5.Sichuan Univ, West China Hosp, Biomed Big Data Ctr, Chengdu 610041, Peoples R China; 6.Tianjin Univ, Tianjin Key Lab Brain Sci & Neural Engn, Acad Med Engn & Translat Med, Tianjin 300072, Peoples R China
第一作者单位	附属第一医院
通讯作者单位	附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Liu, Jianyong,Pei, Yu,Huang, Yingying,et al. A self-assembling bioactive oligopeptide hydrogel for the treatment of edema following prepuce surgery[J]. JOURNAL OF MATERIALS CHEMISTRY B,2024,12(37):9357-9363.
APA	Liu, Jianyong., Pei, Yu., Huang, Yingying., Jiang, Haofei., Tadoh, Mike Pleass Tita., ... & Zhou, Yunlong. (2024). A self-assembling bioactive oligopeptide hydrogel for the treatment of edema following prepuce surgery. JOURNAL OF MATERIALS CHEMISTRY B, 12(37), 9357-9363.
MLA	Liu, Jianyong,et al."A self-assembling bioactive oligopeptide hydrogel for the treatment of edema following prepuce surgery".JOURNAL OF MATERIALS CHEMISTRY B 12.37(2024):9357-9363.