科研成果详情

题名Microenvironment-adaptive nanodecoy synergizes bacterial eradication, inflammation alleviation, and immunomodulation in promoting biofilm-associated diabetic chronic wound healing cascade
作者
发表日期2024-08-08
发表期刊AGGREGATE   影响因子和分区
语种英语
原始文献类型Article ; Early Access
关键词biofilm chronic wound inflammatory cytokines reactive oxygen species synergy therapy
其他关键词NANOPARTICLES
摘要The presence of bacterial biofilms and the occurrence of excessive inflammatory response greatly imped the healing process of chronic wounds in diabetic patients. However, effective strategies to simultaneously address these issues are still lacking. Here, a microenvironment-adaptive nanodecoy (GC@Pd) is constructed via the coordination and in situ reduction of palladium ions on gallic acid-modified chitosan (GC) to promote wound healing by synergistic biofilm eradication, inflammation alleviation, and immunoregulation. During the weakly acidic conditions of the biofilm infection stage, GC@Pd serves as a nanodecoy to induce bacterial aggregation. Subsequently, through its oxidase-like activity generating reactive oxygen species and the hyperthermia from photothermal effects, it effectively eliminates the biofilm. As the local microenvironment of diabetic wounds transitions to an alkaline inflammatory state, the enzyme-like activity of GC@Pd adapts to catalase-like activity, effectively eliminating reactive oxygen species at the site of inflammation. Additionally, GC@Pd could selectively capture pro-inflammatory cytokines through Michael addition reactions. In vivo experiments and transcriptomic analysis confirmed that GC@Pd could accelerate the wound transition from inflammatory to proliferative phase by eliminating biofilm infection and reducing the inflammatory response, thus promoting diabetic chronic wound healing. The nanodecoy provides a potential therapeutic strategy for treating biofilm-infected diabetic chronic wounds. A microenvironment self-adaptive nanodecoy with anti-biofilm and anti-inflammatory effects was constructed through a simple and efficient strategy. During the stage of biofilm infection in the wound, nanodecoy exhibits synergistic antibacterial and anti-biofilm effects through oxidase-like activity and photothermal effect. In the disturbed immune microenvironment, nanodecoy has a strong antioxidant effect and the ability to selectively capture pro-inflammatory cytokines, which could promote the healing process of diabetic wounds by eliminating oxidative stress and blocking inflammatory cascade. image
资助项目China Postdoctoral Science Foundation [2022M723108]; Startup Fund of Wenzhou Institute, University of Chinese Academy of Sciences [WIUCASQD2021022, WIUCASQD2021019]; National Natural Science Foundation of China [22103088, 82204940, 52203184, 22275043, 52293380, 52293383]
出版者WILEY
ISSN2766-8541
EISSN2692-4560
DOI10.1002/agt2.640
页数21
WOS类目Chemistry, Multidisciplinary ; Chemistry, Physical ; Materials Science, Multidisciplinary
WOS研究方向Chemistry ; Materials Science
WOS记录号WOS:001286161900001
收录类别ESCI ; EI
EI入藏号20243216847774
EI主题词Biofilms
EI分类号461.6 Medicine and Pharmacology ; 461.9 Biology ; 462.5 Biomaterials (including synthetics) ; 802.2 Chemical Reactions ; 804 Chemical Products Generally
通讯作者地址[Liu, Yong;Li, Yuanfeng]Wenzhou Med Univ, Affiliated Hosp 1, Joint Ctr Translat Med, Wenzhou 325001, Zhejiang, Peoples R China. ; [Xiao, Jian]Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou 325035, Zhejiang, Peoples R China. ; [Hu, Xiaoli]Wenzhou Med Univ, Affiliated Hosp 1, Dept Gynecol, Wenzhou 325035, Zhejiang, Peoples R China.
引用统计
文献类型期刊论文
条目标识符https://kms.wmu.edu.cn/handle/3ETUA0LF/217336
专题药学院(分析测试中心)
附属第一医院
附属第一医院_妇科
研究生工作部(研究生院)
口腔医学院、附属口腔医院
口腔医学院、附属口腔医院_正畸科
通讯作者Hu, Xiaoli; Xiao, Jian; Liu, Yong; Li, Yuanfeng
作者单位
1.Wenzhou Med Univ, Affiliated Hosp 1, Joint Ctr Translat Med, Wenzhou 325001, Zhejiang, Peoples R China;
2.Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou 325035, Zhejiang, Peoples R China;
3.Univ Chinese Acad Sci, Wenzhou Inst, Wenzhou, Zhejiang, Peoples R China;
4.Wenzhou Med Univ, Sch & Hosp Stomatol, Dept Orthodont, Wenzhou, Zhejiang, Peoples R China;
5.Wenzhou Med Univ, Affiliated Hosp 1, Dept Gynecol, Wenzhou 325035, Zhejiang, Peoples R China;
6.Wenzhou Med Univ, Affiliated Hosp 1, Dept Wound Healing, Wenzhou, Zhejiang, Peoples R China;
7.Nankai Univ, Coll Chem, Key Lab Funct Polymer Mat, Minist Educ,Inst Polymer Chem, Tianjin, Peoples R China
第一作者单位附属第一医院;  药学院(分析测试中心)
通讯作者单位附属第一医院;  药学院(分析测试中心);  妇科
第一作者的第一单位附属第一医院
推荐引用方式
GB/T 7714
Chen, Lei,Peng, Mengna,He, Wei,et al. Microenvironment-adaptive nanodecoy synergizes bacterial eradication, inflammation alleviation, and immunomodulation in promoting biofilm-associated diabetic chronic wound healing cascade[J]. AGGREGATE,2024.
APA Chen, Lei., Peng, Mengna., He, Wei., Hu, Xiaoli., Xiao, Jian., ... & Li, Yuanfeng. (2024). Microenvironment-adaptive nanodecoy synergizes bacterial eradication, inflammation alleviation, and immunomodulation in promoting biofilm-associated diabetic chronic wound healing cascade. AGGREGATE.
MLA Chen, Lei,et al."Microenvironment-adaptive nanodecoy synergizes bacterial eradication, inflammation alleviation, and immunomodulation in promoting biofilm-associated diabetic chronic wound healing cascade".AGGREGATE (2024).

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