Microenvironment-adaptive nanodecoy synergizes bacterial eradication, inflammation alleviation, and immunomodulation in promoting biofilm-associated diabetic chronic wound healing cascade

doi:10.1002/agt2.640

科研成果详情

题名	Microenvironment-adaptive nanodecoy synergizes bacterial eradication, inflammation alleviation, and immunomodulation in promoting biofilm-associated diabetic chronic wound healing cascade
作者	Chen, Lei 1,2,3; Peng, Mengna 1,3; He, Wei4; Hu, Xiaoli5; Xiao, Jian2,3,6; Shi, Linqi 7; Liu, Yong 1,3,7; Li, Yuanfeng1
发表日期	2024-08-08
发表期刊	AGGREGATE 影响因子和分区
语种	英语
原始文献类型	Article ; Early Access
关键词	biofilm chronic wound inflammatory cytokines reactive oxygen species synergy therapy
其他关键词	NANOPARTICLES
摘要	The presence of bacterial biofilms and the occurrence of excessive inflammatory response greatly imped the healing process of chronic wounds in diabetic patients. However, effective strategies to simultaneously address these issues are still lacking. Here, a microenvironment-adaptive nanodecoy (GC@Pd) is constructed via the coordination and in situ reduction of palladium ions on gallic acid-modified chitosan (GC) to promote wound healing by synergistic biofilm eradication, inflammation alleviation, and immunoregulation. During the weakly acidic conditions of the biofilm infection stage, GC@Pd serves as a nanodecoy to induce bacterial aggregation. Subsequently, through its oxidase-like activity generating reactive oxygen species and the hyperthermia from photothermal effects, it effectively eliminates the biofilm. As the local microenvironment of diabetic wounds transitions to an alkaline inflammatory state, the enzyme-like activity of GC@Pd adapts to catalase-like activity, effectively eliminating reactive oxygen species at the site of inflammation. Additionally, GC@Pd could selectively capture pro-inflammatory cytokines through Michael addition reactions. In vivo experiments and transcriptomic analysis confirmed that GC@Pd could accelerate the wound transition from inflammatory to proliferative phase by eliminating biofilm infection and reducing the inflammatory response, thus promoting diabetic chronic wound healing. The nanodecoy provides a potential therapeutic strategy for treating biofilm-infected diabetic chronic wounds. A microenvironment self-adaptive nanodecoy with anti-biofilm and anti-inflammatory effects was constructed through a simple and efficient strategy. During the stage of biofilm infection in the wound, nanodecoy exhibits synergistic antibacterial and anti-biofilm effects through oxidase-like activity and photothermal effect. In the disturbed immune microenvironment, nanodecoy has a strong antioxidant effect and the ability to selectively capture pro-inflammatory cytokines, which could promote the healing process of diabetic wounds by eliminating oxidative stress and blocking inflammatory cascade. image
资助项目	China Postdoctoral Science Foundation [2022M723108]; Startup Fund of Wenzhou Institute, University of Chinese Academy of Sciences [WIUCASQD2021022, WIUCASQD2021019]; National Natural Science Foundation of China [22103088, 82204940, 52203184, 22275043, 52293380, 52293383]
出版者	WILEY
ISSN	2766-8541
EISSN	2692-4560
DOI	10.1002/agt2.640
页数	21
WOS类目	Chemistry, Multidisciplinary ; Chemistry, Physical ; Materials Science, Multidisciplinary
WOS研究方向	Chemistry ; Materials Science
WOS记录号	WOS:001286161900001
收录类别	ESCI ; EI
EI入藏号	20243216847774
EI主题词	Biofilms
EI分类号	461.6 Medicine and Pharmacology ; 461.9 Biology ; 462.5 Biomaterials (including synthetics) ; 802.2 Chemical Reactions ; 804 Chemical Products Generally
通讯作者地址	[Liu, Yong;Li, Yuanfeng]Wenzhou Med Univ, Affiliated Hosp 1, Joint Ctr Translat Med, Wenzhou 325001, Zhejiang, Peoples R China. ; [Xiao, Jian]Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou 325035, Zhejiang, Peoples R China. ; [Hu, Xiaoli]Wenzhou Med Univ, Affiliated Hosp 1, Dept Gynecol, Wenzhou 325035, Zhejiang, Peoples R China.
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/217336
专题	药学院（分析测试中心）附属第一医院附属第一医院_妇科研究生工作部（研究生院）口腔医学院、附属口腔医院口腔医学院、附属口腔医院_正畸科
通讯作者	Hu, Xiaoli; Xiao, Jian; Liu, Yong; Li, Yuanfeng
作者单位	1.Wenzhou Med Univ, Affiliated Hosp 1, Joint Ctr Translat Med, Wenzhou 325001, Zhejiang, Peoples R China; 2.Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou 325035, Zhejiang, Peoples R China; 3.Univ Chinese Acad Sci, Wenzhou Inst, Wenzhou, Zhejiang, Peoples R China; 4.Wenzhou Med Univ, Sch & Hosp Stomatol, Dept Orthodont, Wenzhou, Zhejiang, Peoples R China; 5.Wenzhou Med Univ, Affiliated Hosp 1, Dept Gynecol, Wenzhou 325035, Zhejiang, Peoples R China; 6.Wenzhou Med Univ, Affiliated Hosp 1, Dept Wound Healing, Wenzhou, Zhejiang, Peoples R China; 7.Nankai Univ, Coll Chem, Key Lab Funct Polymer Mat, Minist Educ,Inst Polymer Chem, Tianjin, Peoples R China
第一作者单位	附属第一医院; 药学院（分析测试中心）
通讯作者单位	附属第一医院; 药学院（分析测试中心）; 妇科
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Chen, Lei,Peng, Mengna,He, Wei,et al. Microenvironment-adaptive nanodecoy synergizes bacterial eradication, inflammation alleviation, and immunomodulation in promoting biofilm-associated diabetic chronic wound healing cascade[J]. AGGREGATE,2024.
APA	Chen, Lei., Peng, Mengna., He, Wei., Hu, Xiaoli., Xiao, Jian., ... & Li, Yuanfeng. (2024). Microenvironment-adaptive nanodecoy synergizes bacterial eradication, inflammation alleviation, and immunomodulation in promoting biofilm-associated diabetic chronic wound healing cascade. AGGREGATE.
MLA	Chen, Lei,et al."Microenvironment-adaptive nanodecoy synergizes bacterial eradication, inflammation alleviation, and immunomodulation in promoting biofilm-associated diabetic chronic wound healing cascade".AGGREGATE (2024).