Expert consensus on the diagnosis and treatment of macrolide-resistant Mycoplasma pneumoniae pneumonia in children

doi:10.1007/s12519-024-00831-0

科研成果详情

题名	Expert consensus on the diagnosis and treatment of macrolide-resistant Mycoplasma pneumoniae pneumonia in children
作者	Wang, Ying-Shuo 1; Zhou, Yun-Lian 1; Bai, Guan-Nan 2; Li, Shu-Xian 1; Xu, Dan 1; Chen, Li-Na 3; Chen, Xing 4; Dong, Xiao-Yan 5; Fu, Hong-Min 6; Fu, Zhou 7; Hao, Chuang-Li 8; Hong, Jian-Guo 9; Liu, En-Mei 7; Liu, Han-Min 3; Lu, Xiao-Xia 10; Luo, Zheng-Xiu 7; Tang, Lan-Fang 1; Tian, Man 11; Yin, Yong 12; Zhang, Xiao-Bo 13; Zhang, Jian-Hua 14; Zhang, Hai-Lin15,16; Zhao, De-Yu 11; Zhao, Shun-Ying 17; Zhu, Guo-Hong 1; Zou, Ying-Xue 18; Lu, Quan 5; Zhang, Yuan-Yuan 1; Chen, Zhi-Min 1
发表日期	2024-08-14
发表期刊	World Journal of Pediatrics 影响因子和分区
语种	英语
原始文献类型	Review ; Early Access
关键词	Child Macrolide-resistant Mycoplasma pneumoniae Recommendation Diagnosis Treatment
其他关键词	CLINICAL-MANIFESTATIONS ; INFECTIONS ; EPIDEMIOLOGY ; PCR ; DOXYCYCLINE ; SHANGHAI ; STRAINS ; CHINA ; TIME
摘要	Background Mycoplasma pneumoniae (M. pneumoniae) is a significant contributor to community-acquired pneumonia among children. Since 1968, when a strain of M. pneumoniae resistant to macrolide antibiotics was initially reported in Japan, macrolide-resistant M. pneumoniae (MRMP) has been documented in many countries worldwide, with varying incidence rates. MRMP infections lead to a poor response to macrolide antibiotics, frequently resulting in prolonged fever, extended antibiotic treatment, increased hospitalization, intensive care unit admissions, and a significantly higher proportion of patients receiving glucocorticoids or second-line antibiotics. Since 2000, the global incidence of MRMP has gradually increased, especially in East Asia, which has posed a serious challenge to the treatment of M. pneumoniae infections in children and attracted widespread attention from pediatricians. However, there is still no global consensus on the diagnosis and treatment of MRMP in children. Methods We organized 29 Chinese experts majoring in pediatric pulmonology and epidemiology to write the world's first consensus on the diagnosis and treatment of pediatric MRMP pneumonia, based on evidence collection. The evidence searches and reviews were conducted using electronic databases, including PubMed, Embase, Web of Science, CNKI, Medline, and the Cochrane Library. We used variations in terms for macrolide-resistant, Mycoplasma pneumoniae, MP, M. pneumoniae, pneumonia, MRMP, lower respiratory tract infection, Mycoplasma pneumoniae infection, children, and pediatric. Results Epidemiology, pathogenesis, clinical manifestations, early identification, laboratory examination, principles of antibiotic use, application of glucocorticoids and intravenous immunoglobulin, and precautions for bronchoscopy are highlighted. Early and rapid identification of gene mutations associated with MRMP is now available by polymerase chain reaction and fluorescent probe techniques in respiratory specimens. Although the resistance rate to macrolide remains high, it is fortunate that M. pneumoniae still maintains good in vitro sensitivity to second-line antibiotics such as tetracyclines and quinolones, making them an effective treatment option for patients with initial treatment failure caused by macrolide antibiotics. Conclusions This consensus, based on international and national scientific evidence, provides scientific guidance for the diagnosis and treatment of MRMP in children. Further studies on tetracycline and quinolone drugs in children are urgently needed to evaluate their effects on the growth and development. Additionally, developing an antibiotic rotation treatment strategy is necessary to reduce the prevalence of MRMP strains.
资助项目	Key R & D Projects of Zhejiang Province
出版者	ZHEJIANG UNIV PRESS
ISSN	1708-8569
EISSN	1867-0687
卷号	20 期号:9 页码:901-914
DOI	10.1007/s12519-024-00831-0
页数	14
WOS类目	Pediatrics
WOS研究方向	Pediatrics
WOS记录号	WOS:001291586000001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	39143259
SCOPUSEID	2-s2.0-85201203797
通讯作者地址	[Zhang, Yuan-Yuan;Chen, Zhi-Min]Zhejiang Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth, Sch Med,Dept Plum, Hangzhou 310052, Peoples R China. ; [Lu, Quan]Shanghai Jiao Tong Univ, Shanghai Childrens Hosp, Sch Med, Dept Pulmonol, Shanghai 200062, Peoples R China.
Scopus学科分类	Pediatrics, Perinatology and Child Health
SCOPUS_ID	SCOPUS_ID:85201203797
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/217317
专题	附属第二医院第二临床医学院、附属第二医院、育英儿童医院附属第二医院_儿童呼吸科
通讯作者	Lu, Quan; Zhang, Yuan-Yuan; Chen, Zhi-Min
作者单位	1.Zhejiang Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth, Sch Med,Dept Plum, Hangzhou 310052, Peoples R China; 2.Zhejiang Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth, Sch Med,Dept Child Hlth Care, Hangzhou 310052, Peoples R China; 3.Sichuan Univ, West China Second Univ Hosp, Dept Pediat Pulmonol & Immunol, Chengdu 610041, Peoples R China; 4.Shandong First Med Univ, Dept Pediat, Shandong Prov Hosp, Jinan 250021, Peoples R China; 5.Shanghai Jiao Tong Univ, Shanghai Childrens Hosp, Sch Med, Dept Pulmonol, Shanghai 200062, Peoples R China; 6.Kunming Childrens Hosp, Dept Pulm & Crit Care Med, Kunming 650034, Peoples R China; 7.Chongqing Med Univ, Dept Resp Med, Childrens Hosp, Chongqing 400014, Peoples R China; 8.Soochow Univ, Childrens Hosp, Dept Pulmonol, Suzhou 215003, Peoples R China; 9.Shanghai Jiao Tong Univ, Dept Pediat, Shanghai Gen Hosp, Dept Cardiol,Sch Med, Shanghai 200080, Peoples R China; 10.Huazhong Univ Sci & Technol, Wuhan Childrens Hosp, Tongji Med Coll, Dept Resp Med, Wuhan, Peoples R China; 11.Nanjing Med Univ, Dept Resp Med, Childrens Hosp, Nanjing 210008, Peoples R China; 12.Shanghai Jiao Tong Univ, Shanghai Childrens Med Ctr, Sch Med, Dept Resp Med, Shanghai, Peoples R China; 13.Fudan Univ, Childrens Hosp, Dept Resp Med, Shanghai 201102, Peoples R China; 14.Shanghai Jiao Tong Univ, Xinhua Hosp, Dept Pediat Pulmonol, Sch Med, Shanghai 201102, Peoples R China; 15.Wenzhou Med Univ, Affiliated Hosp 2, Dept Pediat Resp Med, Wenzhou 325027, Peoples R China; 16.Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou 325027, Peoples R China; 17.Capital Med Univ, Beijing Childrens Hosp, Natl Clin Res Ctr Resp Dis, Beijing 100045, Peoples R China; 18.Tianjin Univ, Tianjin Childrens Hosp, Dept Pulmonol, Childrens Hosp, Tianjin 300074, Peoples R China
推荐引用方式 GB/T 7714	Wang, Ying-Shuo,Zhou, Yun-Lian,Bai, Guan-Nan,et al. Expert consensus on the diagnosis and treatment of macrolide-resistant Mycoplasma pneumoniae pneumonia in children[J]. World Journal of Pediatrics,2024,20(9):901-914.
APA	Wang, Ying-Shuo., Zhou, Yun-Lian., Bai, Guan-Nan., Li, Shu-Xian., Xu, Dan., ... & Chen, Zhi-Min. (2024). Expert consensus on the diagnosis and treatment of macrolide-resistant Mycoplasma pneumoniae pneumonia in children. World Journal of Pediatrics, 20(9), 901-914.
MLA	Wang, Ying-Shuo,et al."Expert consensus on the diagnosis and treatment of macrolide-resistant Mycoplasma pneumoniae pneumonia in children".World Journal of Pediatrics 20.9(2024):901-914.