Recent advances in natural polymer-based drug delivery systems

doi:10.1016/j.reactfunctpolym.2020.104501

科研成果详情

题名	Recent advances in natural polymer-based drug delivery systems
作者	Tong, Xianqin 1; Pan, Wenhao 1; Su, Ting 2; Zhang, Mengying 3; Dong, Wei 2; Qi, Xiaoliang3
发表日期	2020-03
发表期刊	REACTIVE & FUNCTIONAL POLYMERS 影响因子和分区
语种	英语
原始文献类型	Review
关键词	Natural polymers Drug delivery systems Polysaccharides Proteins Controlled release
其他关键词	SILK FIBROIN NANOPARTICLES ; DEXTRAN-SPERMINE NANOPARTICLES ; LOADED CHITOSAN FILMS ; SEMI-IPN CRYOGELS ; HYALURONIC-ACID ; IN-VITRO ; CONTROLLED-RELEASE ; GENE DELIVERY ; QUANTUM DOTS ; BIOMEDICAL APPLICATIONS
摘要	Natural polymers have been extensively explored as the vehicles for encapsulation and delivery of drugs and other bioactive molecules, which have attracted tremendous attention. Their inherent advantages in marvelous biocompatibility, controlled enzyme degradation, specific interactions with some biomolecules, and easy modification endow them with versatility in drug delivery. In this perspective, the drug delivery systems (DDS) constructed by representative natural polymers, polysaccharides (chitosan and hyaluronic acid) and proteins (silk fibroin and collagen), are generally summarized. Payloads mainly involve small molecular weight drug, proteins, and DNA for the applications of tissue engineering, wound healing or anticancer therapy. Moreover, the DDS constructed by their derivatives and with other materials also have been presented focusing on the chemical and morphological modifications, the addtions of smart stimuli-triggered or targeted motifs and so on, which evidently promoted the delivery and therapy efficiency. Obviously, more intelligent and specific delivery strategies will be developed and more multifunctional natural polymers based carriers will be expended in the future. We try to seek more insights into the evolution of delivery system so as to figure out what we will truly gain in the next few decades to come.
资助项目	National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [51573078]; Start-up Scientific Research Foundation of Wenzhou Medical University [KYQD20190513]
出版者	ELSEVIER
出版地	AMSTERDAM
ISSN	1381-5148
EISSN	1873-166X
卷号	148
DOI	10.1016/j.reactfunctpolym.2020.104501
页数	18
WOS类目	Chemistry, Applied ; Engineering, Chemical ; Polymer Science
WOS研究方向	Chemistry ; Engineering ; Polymer Science
WOS记录号	WOS:000518708000015
收录类别	SCIE ; EI
EI入藏号	20200408077930
EI主题词	Controlled drug delivery
ESI高被引论文	2021-01 ; 2021-03 ; 2021-05 ; 2021-11 ; 2022-01 ; 2022-03 ; 2022-05 ; 2023-01 ; 2023-03 ; 2023-05 ; 2023-07 ; 2023-09 ; 2023-11 ; 2024-01 ; 2024-03 ; 2024-05 ; 2024-09 ; 2024-11
通讯作者地址	[Dong, Wei]Nanjing Univ Sci & Technol, Sch Chem Engn, Nanjing 210094, Peoples R China. ; [Qi, Xiaoliang]Wenzhou Med Univ, Sch Ophthalmol & Optometry, State Key Lab Ophthalmol Optometry & Vis Sci, Sch Biomed Engn, Wenzhou 325027, Peoples R China.
引用统计	被引频次：89[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/2172
专题	口腔医学院、附属口腔医院眼视光学院（生物医学工程学院）、附属眼视光医院口腔医学院、附属口腔医院_正畸科
通讯作者	Dong, Wei; Qi, Xiaoliang
作者单位	1.Wenzhou Med Univ, Sch Hosp Stomatol, Dept Orthodont, Wenzhou 325027, Peoples R China; 2.Nanjing Univ Sci & Technol, Sch Chem Engn, Nanjing 210094, Peoples R China; 3.Wenzhou Med Univ, Sch Ophthalmol & Optometry, State Key Lab Ophthalmol Optometry & Vis Sci, Sch Biomed Engn, Wenzhou 325027, Peoples R China
第一作者单位	口腔医学院、附属口腔医院; 正畸科
通讯作者单位	眼视光学院（生物医学工程学院）、附属眼视光医院
第一作者的第一单位	口腔医学院、附属口腔医院
推荐引用方式 GB/T 7714	Tong, Xianqin,Pan, Wenhao,Su, Ting,et al. Recent advances in natural polymer-based drug delivery systems[J]. REACTIVE & FUNCTIONAL POLYMERS,2020,148.
APA	Tong, Xianqin, Pan, Wenhao, Su, Ting, Zhang, Mengying, Dong, Wei, & Qi, Xiaoliang. (2020). Recent advances in natural polymer-based drug delivery systems. REACTIVE & FUNCTIONAL POLYMERS, 148.
MLA	Tong, Xianqin,et al."Recent advances in natural polymer-based drug delivery systems".REACTIVE & FUNCTIONAL POLYMERS 148(2020).