Expression of the laminin genes family and its relationship to prognosis in pancreatic carcinoma

doi:10.1016/j.ajg.2024.07.006

科研成果详情

题名	Expression of the laminin genes family and its relationship to prognosis in pancreatic carcinoma
作者	Dai, ShengJie1,2; Kong, Hongru2; Ja, Yang 3; Bao, Liqi 4; Wang, Chengchao 3; Qin, Lei 1
发表日期	2024
发表期刊	Arab Journal of Gastroenterology; 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Epithelial–mesenchymal transition LAMA3 Laminins Pancreatic carcinoma Prognostic biomarkers
其他关键词	TARGETED DISRUPTION ; SERUM BIOMARKER ; BREAST-CANCER ; FIBRONECTIN ; PROGRESSION ; DIAGNOSIS ; MICE
摘要	Background and study aims: Laminin is an extracellular matrix molecule that is the major component of the basement membrane and plays a key role in regulating various processes. However, the association between the laminin gene family and the prognosis of pancreatic carcinoma has not been systematically investigated. Patients and methods: The role of the laminin gene family in pancreatic cancer was evaluated using data from the TCGA database. The effects of different expressions of members of the laminin gene family on pancreatic cancer survival were compared, and their primary cellular roles were examined. The effects of different expressions of positive family genes on proliferation, metastasis, and invasion, as well as EMT and ferroptosis in pancreatic cancer, were also examined. Results: Based on univariate and multifactorial analysis of pancreatic cancer patients, LAMA3 was identified as an independent prognostic factor for overall survival in pancreatic cancer. LAMA3 was found to be enriched in the actin cytoskeleton, P53 signaling pathway, adhesion molecule junctions, pentose phosphate pathway, and regulatory differences in the cell cycle and focal adhesion. Additionally, high expression of LAMA3 was found to promote cancer proliferation, invasion, and metastasis, facilitate the EMT process, and inhibit ferroptosis. Conclusions: Our results identified LAMA3 was associated with the prognosis of patients with pancreatic cancer and may serve as a prognostic biomarker for pancreatic cancer.
资助项目	Basic Scientific Research Project of Wenzhou Science and Technology Bureau [Y20210935]; Youth Cultivation Project of National Clinical Key Speciality (General Surgery, 2021); Major Projects In Universities In Jiangsu Province [19KJA170002]
出版者	ELSEVIER
ISSN	1687-1979
EISSN	2090-2387
卷号	25 期号:3 页码:306-314
DOI	10.1016/j.ajg.2024.07.006
页数	9
WOS类目	Gastroenterology & Hepatology
WOS研究方向	Gastroenterology & Hepatology
WOS记录号	WOS:001301393700001
收录类别	SCOPUS ; PUBMED ; SCIE
URL	查看原文
PubMed ID	39039002
SCOPUSEID	2-s2.0-85199187274
通讯作者地址	[Qin, Lei]The First Affiliated Hospital of Soochow University,No. 188 ShiZi Street, GuSu,Suzhou,215006,China
Scopus学科分类	Gastroenterology
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/217009
专题	附属第一医院第一临床医学院（信息与工程学院）、附属第一医院仁济学院
通讯作者	Qin, Lei
作者单位	1.Department of General Surgery,The First Affiliated Hospital of Soochow University,Jiangsu,Suzhou,China; 2.Department of Hepatobiliary and Pancreatic Surgery,the First Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,China; 3.The First Clinical Medical College,Wenzhou Medical University,Zhejiang,Wenzhou,China; 4.Renji College,Wenzhou Medical University,Zhejiang,Wenzhou,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
推荐引用方式 GB/T 7714	Dai, ShengJie,Kong, Hongru,Ja, Yang,et al. Expression of the laminin genes family and its relationship to prognosis in pancreatic carcinoma[J]. Arab Journal of Gastroenterology;,2024,25(3):306-314.
APA	Dai, ShengJie, Kong, Hongru, Ja, Yang, Bao, Liqi, Wang, Chengchao, & Qin, Lei. (2024). Expression of the laminin genes family and its relationship to prognosis in pancreatic carcinoma. Arab Journal of Gastroenterology;, 25(3), 306-314.
MLA	Dai, ShengJie,et al."Expression of the laminin genes family and its relationship to prognosis in pancreatic carcinoma".Arab Journal of Gastroenterology; 25.3(2024):306-314.