Unveiling the Intricate Connection: Cell Volume as a Key Regulator of Mechanotransduction

doi:10.1146/annurev-biophys-030822-035656

科研成果详情

题名	Unveiling the Intricate Connection: Cell Volume as a Key Regulator of Mechanotransduction
作者	Xie, Jing 1; Huck, Wilhelm T.S.2; Bao, Min 3
发表日期	2024-07-16
发表期刊	Annual Review of Biophysics; 影响因子和分区
语种	英语
原始文献类型	Review
关键词	cell fate determination cell mechanics cell volume macromolecular crowding mechanotransduction
其他关键词	SIZE CONTROL ; GENE-EXPRESSION ; MOLECULAR-MECHANISMS ; NUCLEAR SIZE ; GROWTH ; ACTIVATION ; MATRIX ; TRANSCRIPTION ; METABOLISM ; TRANSITION
摘要	The volumes of living cells undergo dynamic changes to maintain the cells' structural and functional integrity in many physiological processes. Minor fluctuations in cell volume can serve as intrinsic signals that play a crucial role in cell fate determination during mechanotransduction. In this review, we discuss the variability of cell volume and its role in vivo, along with an overview of the mechanisms governing cell volume regulation. Additionally, we provide insights into the current approaches used to control cell volume in vitro. Furthermore, we summarize the biological implications of cell volume regulation and discuss recent advances in understanding the fundamental relationship between cell volume and mechanotransduction. Finally, we delve into the potential underlying mechanisms, including intracellular macromolecular crowding and cellular mechanics, that govern the global regulation of cell fate in response to changes in cell volume. By exploring the intricate interplay between cell volume and mechanotransduction, we underscore the importance of considering cell volume as a fundamental signaling cue to unravel the basic principles of mechanotransduction. Additionally, we propose future research directions that can extend our current understanding of cell volume in mechanotransduction. Overall, this review highlights the significance of considering cell volume as a fundamental signal in understanding the basic princi- ples in mechanotransduction and points out the possibility of controlling cell volume to control cell fate, mitigate disease-related damage, and facilitate the healing of damaged tissues.
资助项目	National Natural Science Foundation of China[12302410,OJQD2022015];Zhejiang Lab for Regenerative Medicine, Vision[82301873];
出版者	ANNUAL REVIEWS
ISSN	1936-122X
EISSN	1936-1238
卷号	53 期号:1 页码:299-317
DOI	10.1146/annurev-biophys-030822-035656
页数	19
WOS类目	Biophysics
WOS研究方向	Biophysics
WOS记录号	WOS:001278237500014
收录类别	SCOPUS ; PUBMED ; SCIE
URL	查看原文
PubMed ID	38424091
SCOPUSEID	2-s2.0-85199126182
通讯作者地址	[Huck, Wilhelm T. S.]Radboud Univ Nijmegen, Inst Mol & Mat, Nijmegen, Netherlands.
Scopus学科分类	Biophysics;Structural Biology;Bioengineering;Biochemistry;Cell Biology
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/216973
专题	附属第一医院其他_瓯江实验室
通讯作者	Huck, Wilhelm T.S.
作者单位	1.Institute of Biomedical Engineering,West China School of Basic Medical Sciences & Forensic Medicine,Sichuan University,Chengdu,China; 2.Institute for Molecules and Materials,Radboud University,Nijmegen,Netherlands; 3.Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine,Vision and Brain Health),First Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,China
推荐引用方式 GB/T 7714	Xie, Jing,Huck, Wilhelm T.S.,Bao, Min. Unveiling the Intricate Connection: Cell Volume as a Key Regulator of Mechanotransduction[J]. Annual Review of Biophysics;,2024,53(1):299-317.
APA	Xie, Jing, Huck, Wilhelm T.S., & Bao, Min. (2024). Unveiling the Intricate Connection: Cell Volume as a Key Regulator of Mechanotransduction. Annual Review of Biophysics;, 53(1), 299-317.
MLA	Xie, Jing,et al."Unveiling the Intricate Connection: Cell Volume as a Key Regulator of Mechanotransduction".Annual Review of Biophysics; 53.1(2024):299-317.