Identification of symptom clusters and change trajectories in patients with acute exacerbation of chronic obstructive pulmonary disease

doi:10.1016/j.heliyon.2024.e33745

科研成果详情

题名	Identification of symptom clusters and change trajectories in patients with acute exacerbation of chronic obstructive pulmonary disease
作者	Xu, Mengying 1; Yu, Chunchun1; Lin, Xiaona1; Shi, Jiaqi1; Pang, Xinyue1; Chen, Zhi 1; Zhao, Hongjun2; Chen, Chengshui1,2
发表日期	2024-07-15
发表期刊	HELIYON 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Acute exacerbation of chronic obstructive pulmonary disease Symptom clusters Nursing Physiological mechanism
其他关键词	COPD ; OUTCOMES
摘要	Aim and objectives: This study aimed to identify symptom cluster (SC) patterns and change trajectories in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD), the correlation of the SCs with laboratory and imaging indicators, and the intrinsic association of the SCs with prognostic outcomes and disease burden. Method: Symptom information was collected using a digital evaluation scoring system at the time of admission, on the third day after admission, and upon discharge. Laboratory and imaging examination data were compiled simultaneously. Exploratory factor analysis was used to identify the AECOPD SCs. The number of factors (clusters) was determined by examining factors with eigenvalues >= 1.0, using 0.50 for factor loadings as the minimum cut-off value. Spearman's correlation analysis was used to explore the link between the SCs and laboratory and imaging indicators, as well as the relationship between the severity of the symptoms in different clusters, prognostic outcomes, and disease burden. Results: This study included 148 patients. Three SCs were identified: activity-nutrition SC, breathsleep SC and respiratory SC. Correlation analysis indicated a connection between the activitynutrition SC and the white blood cell count, and serum sodium and potassium levels, whereas the breath-sleep SC was correlated with white blood cells and eosinophil counts, serum potassium level, and pleural effusion. Additionally, the respiratory SC was associated with serum calcium and magnesium levels, the partial pressure of carbon dioxide, and C-reactive protein (CRP) level. There was a positive correlation between the activity-nutrition SC and hospitalization cost, as well as between the breath-sleep SC and both the hospitalization length and cost. Conclusion: Patients with AECOPD presented three SCs that affected the length and cost of hospitalization. Concurrently, the severity of the symptoms in the clusters was related to white blood cell and eosinophil counts; serum sodium, potassium, calcium, and magnesium levels; CRP level; the partial pressure of carbon dioxide; and pleural effusion, indicating that the symptoms in each clusters may share related physiological mechanisms. An in-depth exploration of the pathogenesis and intervention paths of health problems is of great significance for promoting precision nursing.
资助项目	National Key Research and Development Program of China [2016YFC1304000]; National Natural Scientific Foundation of China [82170017, 82370085]; Zhejiang Provincial Key Research and Development Program [2020C03067]
出版者	CELL PRESS
ISSN	2405-8440
EISSN	2405-8440
卷号	10 期号:13
DOI	10.1016/j.heliyon.2024.e33745
页数	10
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
WOS记录号	WOS:001267596000001
收录类别	SCIE ; SCOPUS ; PUBMED
URL	查看原文
PubMed ID	39071711
SCOPUSEID	2-s2.0-85197653815
通讯作者地址	[Chen, Chengshui]Wenzhou Med Univ, Affiliated Hosp 1, Dept Pulm & Crit Care Med, Key Lab Intervent Pulmonol Zhejiang Prov, Wenzhou 325000, Peoples R China. ; [Zhao, Hongjun;Chen, Chengshui]Wenzhou Med Univ, Quzhou Peoples Hosp, Zhejiang Prov Engn Res Ctr Endoscope Instruments &, Clin Res Ctr,Quzhou Affiliated Hosp, Quzhou 324000, Peoples R China.
Scopus学科分类	Multidisciplinary
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/216871
专题	第一临床医学院（信息与工程学院）、附属第一医院_内科学_呼吸与危重症医学科其他_温州医科大学附属衢州医院
通讯作者	Zhao, Hongjun; Chen, Chengshui
作者单位	1.Wenzhou Med Univ, Affiliated Hosp 1, Dept Pulm & Crit Care Med, Key Lab Intervent Pulmonol Zhejiang Prov, Wenzhou 325000, Peoples R China; 2.Wenzhou Med Univ, Quzhou Peoples Hosp, Zhejiang Prov Engn Res Ctr Endoscope Instruments &, Clin Res Ctr,Quzhou Affiliated Hosp, Quzhou 324000, Peoples R China
第一作者单位	第一临床医学院（信息与工程学院）、附属第一医院_内科学_呼吸与危重症医学科
通讯作者单位	第一临床医学院（信息与工程学院）、附属第一医院_内科学_呼吸与危重症医学科; 其他_温州医科大学附属衢州医院
第一作者的第一单位	第一临床医学院（信息与工程学院）、附属第一医院_内科学_呼吸与危重症医学科
推荐引用方式 GB/T 7714	Xu, Mengying,Yu, Chunchun,Lin, Xiaona,et al. Identification of symptom clusters and change trajectories in patients with acute exacerbation of chronic obstructive pulmonary disease[J]. HELIYON,2024,10(13).
APA	Xu, Mengying., Yu, Chunchun., Lin, Xiaona., Shi, Jiaqi., Pang, Xinyue., ... & Chen, Chengshui. (2024). Identification of symptom clusters and change trajectories in patients with acute exacerbation of chronic obstructive pulmonary disease. HELIYON, 10(13).
MLA	Xu, Mengying,et al."Identification of symptom clusters and change trajectories in patients with acute exacerbation of chronic obstructive pulmonary disease".HELIYON 10.13(2024).