Exploring the association of physical activity on cognitive function in older adults from observational and genetic insights: a combined NHANES and Mendelian randomization study

doi:10.3389/fnagi.2024.1418455

科研成果详情

题名	Exploring the association of physical activity on cognitive function in older adults from observational and genetic insights: a combined NHANES and Mendelian randomization study
作者	Liu, Hai-yan1; Zhang, Yi-Jing 2; Zhang, Wen-you1
发表日期	2024-07-03
发表期刊	FRONTIERS IN AGING NEUROSCIENCE 影响因子和分区
语种	英语
原始文献类型	Article
关键词	physical activity cognitive function older adults NHANES Mendelian randomization
其他关键词	NEUROTROPHIC FACTOR ; IMPAIRMENT ; PARTICIPATION ; INSTRUMENTS ; EXERCISE
摘要	Background Cognitive function (CF) deterioration is a pressing concern in geriatric research. This study aimed to explore the relationship between physical activity (PA) and CF in older adults.Methods This study adopted a dual approach, employing both observational and genetic approaches through data from the National Health and Nutrition Examination Survey (NHANES) 2011-2014 and Mendelian Randomization (MR) analysis. For the NHANES component, PA levels were evaluated using the Global Physical Activity Questionnaire, and CF was assessed via standardized tests. Multivariate regression, threshold effect analysis, smoothing curve fitting, and subgroup analyses were conducted to examine the association between PA and CF. In parallel, MR methods, using genetic variants as instrumental variables, assessed the causal impact of PA on CF and related conditions such as Alzheimer's disease and dementia.Results Observational findings from NHANES demonstrated a positive correlation between PA and CF, notably among female participants. The detailed analysis identified specific thresholds of PA that correlate with cognitive enhancements. However, MR results did not support a significant causal relationship between PA and CF or dementia-related outcomes, indicating an absence of a direct genetic basis for the observational associations.Conclusion Although observational data from NHANES suggest that PA is positively associated with CF in older adults, particularly among women, MR analysis did not confirm these findings as causally related. The discrepancy highlights the complexity of the PA-CF relationship and underscores the need for further research. These results emphasize the potential of PA as a modifiable risk factor for CF, though causal effects remain to be definitively established.
资助项目	NHANES; IEU Open GWAS Project
出版者	FRONTIERS MEDIA SA
ISSN	1663-4365
卷号	16
DOI	10.3389/fnagi.2024.1418455
页数	11
WOS类目	Geriatrics & Gerontology ; Neurosciences
WOS研究方向	Geriatrics & Gerontology ; Neurosciences & Neurology
WOS记录号	WOS:001268780600001
收录类别	SCIE ; SCOPUS ; PUBMED
URL	查看原文
PubMed ID	39021706
SCOPUSEID	2-s2.0-85198652218
通讯作者地址	[Zhang, Wen-you]Wenzhou Med Univ, Affiliated Hosp 1, Dept Anesthesiol, Wenzhou, Zhejiang, Peoples R China.
Scopus学科分类	Aging;Cognitive Neuroscience
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/216861
专题	附属第一医院_麻醉科附属第一医院_产科
通讯作者	Zhang, Wen-you
作者单位	1.Wenzhou Med Univ, Affiliated Hosp 1, Dept Anesthesiol, Wenzhou, Zhejiang, Peoples R China; 2.Wenzhou Med Univ, Affiliated Hosp 1, Dept Obstet, Wenzhou, Zhejiang, Peoples R China
第一作者单位	附属第一医院_麻醉科
通讯作者单位	附属第一医院_麻醉科
第一作者的第一单位	附属第一医院_麻醉科
推荐引用方式 GB/T 7714	Liu, Hai-yan,Zhang, Yi-Jing,Zhang, Wen-you. Exploring the association of physical activity on cognitive function in older adults from observational and genetic insights: a combined NHANES and Mendelian randomization study[J]. FRONTIERS IN AGING NEUROSCIENCE,2024,16.
APA	Liu, Hai-yan, Zhang, Yi-Jing, & Zhang, Wen-you. (2024). Exploring the association of physical activity on cognitive function in older adults from observational and genetic insights: a combined NHANES and Mendelian randomization study. FRONTIERS IN AGING NEUROSCIENCE, 16.
MLA	Liu, Hai-yan,et al."Exploring the association of physical activity on cognitive function in older adults from observational and genetic insights: a combined NHANES and Mendelian randomization study".FRONTIERS IN AGING NEUROSCIENCE 16(2024).