Retinal sublayer analysis in juvenile systemic lupus erythematosus without lupus retinopathy

doi:10.1007/s10067-024-07064-6

科研成果详情

题名	Retinal sublayer analysis in juvenile systemic lupus erythematosus without lupus retinopathy
作者	Xu, Sisi1; Zhang, Yu 2,3
发表日期	2024-07-10
发表期刊	Clinical Rheumatology 影响因子和分区
语种	英语
原始文献类型	Article ; Early Access
关键词	Ganglion cell layer Juvenile systemic lupus erythematosus Optical coherence tomography Peripapillary retinal nerve fiber layer
摘要	IntroductionWe aimed to analyze the thicknesses of the retinal sublayer and peripapillary retinal nerve fiber layer (pRNFL) in patients with juvenile systemic lupus erythematosus (JSLE) without lupus retinopathy.MethodsThirty-six patients with JSLE (36 eyes) and 30 control subjects (30 eyes) were included retrospectively. Demographic data, disease duration, and clinical manifestations were recorded. Optical coherence tomography was used to examine the macula and optic disc. The thicknesses of the retina, ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer (ONL), retinal pigment epithelium (RPE), and pRNFL were measured. The correlation between the thickness of retina and disease duration, erythrocyte sedimentation rate (ESR) were investigated.ResultsThe retinal thicknesses of I3 and T3 were thinner in the JSLE group than in the control group (P = 0.019, P = 0.043, respectively). The thicknesses of the I3 and S6 sectors of the GCL decreased significantly (P = 0.013, and P = 0.022, respectively). The thickness of the S6 sector of the IPL was reduced in the JSLE group compared with the control group (P = 0.047). The JSLE group showed significant decrease in the thickness of the central sector of the ONL (P = 0.034). No statistically significant differences in INL, OPL, RPE, and pRNFL thicknesses were found. The retinal thicknesses of I3 (r = -0.386, P = 0.020) and T3 (r = -0.384, P = 0.021) presented negative associations with ESR, but had no significant correlations with disease duration.ConclusionsRetinal thinning was observed in patients with JSLE without lupus retinopathy, and this change was more pronounced in the inner layer. Key Points center dot Retinal thinning occurs in JSLE patients without lupus retinopathy.center dot Changes in retinal thicknesses are related to the ESR.
资助项目	Science and Technology Plan Project of Wenzhou Municipality
出版者	SPRINGER LONDON LTD
ISSN	0770-3198
EISSN	1434-9949
卷号	43 期号:9 页码:2825-2831
DOI	10.1007/s10067-024-07064-6
页数	7
WOS类目	Rheumatology
WOS研究方向	Rheumatology
WOS记录号	WOS:001265179000001
收录类别	SCIE ; SCOPUS ; PUBMED
URL	查看原文
PubMed ID	38982013
SCOPUSEID	2-s2.0-85197783273
通讯作者地址	[Zhang, Yu]Wenzhou Med Univ, Affiliated Hosp 2, Dept Ophthalmol, Wenzhou, Peoples R China. ; [Zhang, Yu]Yuying Childrens Hosp, Wenzhou, Peoples R China.
Scopus学科分类	Rheumatology
SCOPUS_ID	SCOPUS_ID:85197783273
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/216844
专题	附属第一医院附属第二医院第二临床医学院、附属第二医院、育英儿童医院附属第二医院_眼科附属第一医院_眼科
通讯作者	Zhang, Yu
作者单位	1.Wenzhou Med Univ, Affiliated Hosp 1, Dept Ophthalmol, Wenzhou, Peoples R China; 2.Wenzhou Med Univ, Affiliated Hosp 2, Dept Ophthalmol, Wenzhou, Peoples R China; 3.Yuying Childrens Hosp, Wenzhou, Peoples R China
第一作者单位	附属第一医院; 眼科
通讯作者单位	附属第二医院; 第二临床医学院，附属第二医院、育英儿童医院; 眼科
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Xu, Sisi,Zhang, Yu. Retinal sublayer analysis in juvenile systemic lupus erythematosus without lupus retinopathy[J]. Clinical Rheumatology,2024,43(9):2825-2831.
APA	Xu, Sisi, & Zhang, Yu. (2024). Retinal sublayer analysis in juvenile systemic lupus erythematosus without lupus retinopathy. Clinical Rheumatology, 43(9), 2825-2831.
MLA	Xu, Sisi,et al."Retinal sublayer analysis in juvenile systemic lupus erythematosus without lupus retinopathy".Clinical Rheumatology 43.9(2024):2825-2831.