The relationship between neuromyelitis optica spectrum disorder and autoimmune diseases

doi:10.3389/fimmu.2024.1406409

科研成果详情

题名	The relationship between neuromyelitis optica spectrum disorder and autoimmune diseases
作者	Lin, Jie 1; Xue, Binbin2; Li, Jia 1; Xie, Dewei1; Weng, Yiyun1; Zhang, Xu1; Li, Xiang1; Xia, Junhui1
发表日期	2024-06-27
发表期刊	FRONTIERS IN IMMUNOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Neuromyelitis optica sectrum disorders autoimmune disease annualized relapse rate (ARR) autoimmune antibodies prognosis
其他关键词	CLASSIFICATION CRITERIA ; MYASTHENIA-GRAVIS ; DIAGNOSIS ; CONSENSUS
摘要	Objective There have been reports of neuromyelitis optica spectrum disorder (NMOSD) coexisting with connective tissue disorders. The objective of this study was to describe the characteristics of NMOSD coexisting with autoimmune diseases (AID).Methods This retrospective study evaluated NMOSD patients with and without AID. The enrolled patients had at least one attack, with duration of more than 1 year. Data on the demographics, clinical features, and laboratory findings were assessed. The Poisson model was used to investigate the risk factors associated with the annualized relapse rate (ARR), whereas the Cox model was used to evaluate the risk factors for the first relapse.Results A total of 180 patients (154 women and 26 men) with NMOSD were identified: 45 had AID and 135 did not. Female patients had a higher prevalence of concomitant AID (p = 0.006) and a greater relapse rate within the first year. There were no statistically significant differences in the characteristics of patients. Kaplan-Meier analysis revealed that NMOSD patients with seropositive aquaporin 4 antibodies (AQP4-Ab; log-rank: p = 0.044), had a shorter time to relapse. Patients seropositive for AQP4-Ab (HR = 2.402, 95%CI = 1.092-5.283, p = 0.029) had a higher risk of suffering a first relapse, according to the Cox model. Patients with and without AID showed a similar declining tendency in terms of change in ARR throughout the first 5 years of the disease. The ARR was greater in the first year [incidence rate ratio (IRR) = 1.534, 95%CI = 1.111-2.118] and the first 2 years (IRR = 1.474, 95%CI = 1.056-2.058) in patients with coexisting AID diagnosis prior to the NMOSD onset.Conclusions Patients with NMOSD with coexisting AID had similar characteristics when compared with those without AID. NMOSD patients with AID diagnosed before onset had a higher risk of relapse in the early stage of the disease.
资助项目	Wenzhou Science and Technology Bureau [Y20210168]
出版者	FRONTIERS MEDIA SA
ISSN	1664-3224
卷号	15
DOI	10.3389/fimmu.2024.1406409
页数	8
WOS类目	Immunology
WOS研究方向	Immunology
WOS记录号	WOS:001268994400001
收录类别	SCIE ; SCOPUS
URL	查看原文
PubMed ID	38994358
SCOPUSEID	2-s2.0-85198078741
通讯作者地址	[Li, Xiang;Xia, Junhui]Wenzhou Med Univ, Dept Neurol, Affiliated Hosp 1, Wenzhou, Peoples R China.
Scopus学科分类	Immunology and Allergy;Immunology
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/216842
专题	第一临床医学院（信息与工程学院）、附属第一医院_内科学_神经内科附属第一医院_麻醉科
通讯作者	Li, Xiang; Xia, Junhui
作者单位	1.Wenzhou Med Univ, Dept Neurol, Affiliated Hosp 1, Wenzhou, Peoples R China; 2.Wenzhou Med Univ, Dept Anesthesiol, Affiliated Hosp 1, Wenzhou, Peoples R China
第一作者单位	第一临床医学院（信息与工程学院）、附属第一医院_内科学_神经内科
通讯作者单位	第一临床医学院（信息与工程学院）、附属第一医院_内科学_神经内科
第一作者的第一单位	第一临床医学院（信息与工程学院）、附属第一医院_内科学_神经内科
推荐引用方式 GB/T 7714	Lin, Jie,Xue, Binbin,Li, Jia,et al. The relationship between neuromyelitis optica spectrum disorder and autoimmune diseases[J]. FRONTIERS IN IMMUNOLOGY,2024,15.
APA	Lin, Jie., Xue, Binbin., Li, Jia., Xie, Dewei., Weng, Yiyun., ... & Xia, Junhui. (2024). The relationship between neuromyelitis optica spectrum disorder and autoimmune diseases. FRONTIERS IN IMMUNOLOGY, 15.
MLA	Lin, Jie,et al."The relationship between neuromyelitis optica spectrum disorder and autoimmune diseases".FRONTIERS IN IMMUNOLOGY 15(2024).