Schisandrin B alleviates angiotensin II-induced cardiac inflammatory remodeling by inhibiting the recruitment of MyD88 to TLRs in mouse cardiomyocytes

doi:10.1016/j.intimp.2024.112660

科研成果详情

题名	Schisandrin B alleviates angiotensin II-induced cardiac inflammatory remodeling by inhibiting the recruitment of MyD88 to TLRs in mouse cardiomyocytes
作者	Xu, Sujing1,2; Hu, Chenghong 3; Han, Jibo4; Luo, Wu 4; Huang, Lijiang1; Jiang, Yongsheng1; Samorodov, Aleksandr, V 5; Wang, Yi 1,3; Huang, Jianxiong 1
发表日期	2024-09-30
发表期刊	International Immunopharmacology 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Schisandrin B Ang II Inflammation Cardiac inflammatory remodeling MyD88 TLRs
其他关键词	SIGNALING PATHWAY ; HYPERTROPHY ; RECOGNITION ; PRESSURE ; PROTEINS ; TRIF
摘要	Cardiac tissue remodeling is characterized by altered heart tissue architecture and dysfunction, leading to heart failure. Sustained activation of the renin-angiotensin-aldosterone system (RAAS) greatly promotes the development of myocardial remodeling. Angiotensin II (Ang II), which is the major component of RAAS, can directly lead to cardiac remodeling by inducing an inflammatory response. Schisandrin B (Sch B), the active component extracted from the fruit of Schisandra chinensis (Turcz.) Baill has been shown to exhibit anti-inflammatory activity through its ability to target TLR4 and its adaptor protein, MyD88. In this study, we explored whether Sch B alleviates Ang II-induced myocardial inflammation and remodeling via targeting MyD88. Sch B significantly suppressed Ang II-induced inflammation as well as increased the expression of several genes of tissue remodeling (beta-Mhc, Tgfb, Anp, alpha-Ska) both in vivo and in vitro. These protective effects of Sch B were due to the inhibition of recruitment of MyD88 to TLR2 and TLR4, suppressing the Ang II-induced NF-kappa B activation and reducing the following inflammatory responses. Moreover, the knockdown of Myd88 in cardiomyocytes abrogated the Ang IIinduced increases in the production of inflammatory cytokines and expression of remodeling genes. These findings provide new evidence that the mechanism of Sch B protection was attributed to selective inhibition of MyD88 signaling. This finding could pave the way for novel therapeutic strategies for myocardial inflammatory diseases.
资助项目	National Natural Science Foundation of China [82361138563]; Russian Science Foundation [24-45-00071]
出版者	ELSEVIER
ISSN	1567-5769
EISSN	1878-1705
卷号	139
DOI	10.1016/j.intimp.2024.112660
页数	10
WOS类目	Immunology ; Pharmacology & Pharmacy
WOS研究方向	Immunology ; Pharmacology & Pharmacy
WOS记录号	WOS:001272062700001
收录类别	SCIE ; SCOPUS ; PUBMED
URL	查看原文
PubMed ID	39018688
SCOPUSEID	2-s2.0-85198502864
通讯作者地址	[Wang, Yi;Huang, Jianxiong]Wenzhou Med Univ, Joint Res Ctr Med, Affiliated Xiangshan Hosp, Ningbo 315700, Peoples R China.
Scopus学科分类	Immunology and Allergy;Immunology;Pharmacology
SCOPUS_ID	SCOPUS_ID:85198502864
TOP期刊	TOP期刊
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/216750
专题	其他_附属象山医院（象山县第一人民医院）口腔医学院、附属口腔医院口腔医学院、附属口腔医院_口腔医学研究所药学院（分析测试中心）_生物有机与药物化学研究中心
通讯作者	Wang, Yi; Huang, Jianxiong
作者单位	1.Wenzhou Med Univ, Joint Res Ctr Med, Affiliated Xiangshan Hosp, Ningbo 315700, Peoples R China; 2.Wenzhou Med Univ, Sch & Hosp Stomatol, Inst Stomatol, Wenzhou 325027, Peoples R China; 3.Hangzhou Normal Univ, Sch Pharm, Hangzhou 311121, Peoples R China; 4.Wenzhou Med Univ, Chem Biol Res Ctr, Sch Pharmaceut Sci, Wenzhou 325035, Peoples R China; 5.Bashkir State Med Univ, Dept Pharmacol, Ufa 450005, Russia
第一作者单位	附属象山医院（象山县第一人民医院）; 口腔医学院、附属口腔医院; 口腔医学研究所
通讯作者单位	附属象山医院（象山县第一人民医院）
第一作者的第一单位	附属象山医院（象山县第一人民医院）
推荐引用方式 GB/T 7714	Xu, Sujing,Hu, Chenghong,Han, Jibo,et al. Schisandrin B alleviates angiotensin II-induced cardiac inflammatory remodeling by inhibiting the recruitment of MyD88 to TLRs in mouse cardiomyocytes[J]. International Immunopharmacology,2024,139.
APA	Xu, Sujing., Hu, Chenghong., Han, Jibo., Luo, Wu., Huang, Lijiang., ... & Huang, Jianxiong. (2024). Schisandrin B alleviates angiotensin II-induced cardiac inflammatory remodeling by inhibiting the recruitment of MyD88 to TLRs in mouse cardiomyocytes. International Immunopharmacology, 139.
MLA	Xu, Sujing,et al."Schisandrin B alleviates angiotensin II-induced cardiac inflammatory remodeling by inhibiting the recruitment of MyD88 to TLRs in mouse cardiomyocytes".International Immunopharmacology 139(2024).