科研成果详情

题名Reaction-Induced Self-Assembly of Polymyxin Mitigates Cytotoxicity and Reverses Drug Resistance
作者
发表日期2024-07-18
发表期刊Advanced Materials   影响因子和分区
语种英语
原始文献类型Article ; Early Access
关键词antibiotic resistance bacterial biofilms Imine bond formation murine pneumonia subcutaneous infections
其他关键词COLISTIN
摘要Polymyxins have been regarded as an efficient therapeutic against many life-threatening, multidrug resistant Gram-negative bacterial infections; however, the cytotoxicity and emergence of drug resistance associated with polymyxins have greatly hindered their clinical potential. Herein, the reaction-induced self-assembly (RISA) of polymyxins and natural aldehydes in aqueous solution is presented. The resulting assemblies effectively mask the positively charged nature of polymyxins, reducing their cytotoxicity. Moreover, the representative PMBA4 (composed of polymyxin B (PMB) and (E)-2-heptenal (A4)) assemblies demonstrate enhanced binding to Gram-negative bacterial outer membranes and exhibit multiple antimicrobial mechanisms, including increased membrane permeability, elevated bacterial metabolism, suppression of quorum sensing, reduced ATP synthesis, and potential reduction of bacterial drug resistance. Remarkably, PMBA4 assemblies reverse drug resistance in clinically isolated drug-resistant strains of Gram-negative bacteria, demonstrating exceptional efficacy in preventing and eradicating bacterial biofilms. PMBA4 assemblies efficiently eradicate Gram-negative bacterial biofilm infections in vivo and alleviate inflammatory response. This RISA strategy offers a practical and clinically applicable approach to minimize side effects, reverse drug resistance, and prevent the emergence of resistance associated with free polymyxins. The first example of reaction-induced self-assembly (RISA) is presented in the aqueous solution of antibiotics and adjuvants via dynamic covalent bonding. The resulting assemblies via RISA effectively mask the positive charge of polymyxins, preventing their interaction with negatively charged mammalian cells and reducing potential cytotoxicity, enhancing the bactericidal efficacy of polymyxins and preventing the emergence of further resistance. image
资助项目National Key RD Program [2023YFB3809902]; National Natural Science Foundation of China [52293383, 22275043, 52203184, 52303181, 32102689]; Chinese National Foreign Experts Program for Belt and Road Initiative Innovative Talent Exchange [DL2022016004L]; Zhejiang Provincial Natural Science Foundation Outstanding Youth Project [LR24H180001]; Key Laboratory of Clinical Laboratory Diagnosis and Translational Research of Zhejiang Province [2022E10022]; Wenzhou Municipal Science and Technology Major Project [ZY2023031]; Startup Fund of Wenzhou Institute, University of Chinese Academy of Sciences [WIUCASQD2021022, WIUCASQD2021019]; Wenzhou Key Laboratory of Biomaterials and Engineering [WIUCASSWCL21006]; The 1000-Talent Program in Sichuan Province [2287, 1923]; Science and Technology Project of Sichuan Province [2022YFH0057]; Scientific Research Center of Wenzhou Medical University; Science and Technology Project of Sichuan Province [2022YFH0062, 2022ZYD0068]; Shanghai OE Biotech Co., Ltd.
出版者WILEY-V C H VERLAG GMBH
ISSN0935-9648
EISSN1521-4095
卷号36期号:36
DOI10.1002/adma.202406156
页数15
WOS类目Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS记录号WOS:001270529700001
收录类别SCIE ; EI ; SCOPUS ; PUBMED
EI入藏号20242916723055
EI主题词Self assembly
EI分类号461.9 Biology ; 462.5 Biomaterials (including synthetics) ; 951 Materials Science
URL查看原文
PubMed ID39022883
SCOPUSEID2-s2.0-85198755604
通讯作者地址[Piao, Yinzi;Li, Yuanfeng;Liu, Yong]Wenzhou Med Univ, Joint Ctr Translat Med, Key Lab Clin Lab Diag & Translat Res Zhejiang Prov, Affiliated Hosp 1, Wenzhou 325035, Zhejiang, Peoples R China. ; [Piao, Yinzi;Liu, Yong]Univ Chinese Acad Sci, Wenzhou Inst, Wenzhou 325001, Zhejiang, Peoples R China. ; [Zhao, Xinghong]Sichuan Agr Univ, Ctr Sustainable Antimicrobials, Dept Pharm, Chengdu 611130, Peoples R China. ; [Liu, Yong]Nankai Univ, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China.
Scopus学科分类Materials Science (all);Mechanics of Materials;Mechanical Engineering
SCOPUS_IDSCOPUS_ID:85198755604
引用统计
文献类型期刊论文
条目标识符https://kms.wmu.edu.cn/handle/3ETUA0LF/216692
专题附属第一医院
口腔医学院、附属口腔医院
口腔医学院、附属口腔医院_正畸科
通讯作者Piao, Yinzi; Zhao, Xinghong; Li, Yuanfeng; Liu, Yong
作者单位
1.Wenzhou Med Univ, Joint Ctr Translat Med, Key Lab Clin Lab Diag & Translat Res Zhejiang Prov, Affiliated Hosp 1, Wenzhou 325035, Zhejiang, Peoples R China;
2.Wenzhou Med Univ, Sch & Hosp Stomatol, Dept Orthodont, Wenzhou 325027, Zhejiang, Peoples R China;
3.Univ Chinese Acad Sci, Wenzhou Inst, Wenzhou 325001, Zhejiang, Peoples R China;
4.Sichuan Agr Univ, Ctr Sustainable Antimicrobials, Dept Pharm, Chengdu 611130, Peoples R China;
5.Wenzhou Med Univ, Dept Clin Lab, Key Lab Clin Lab Diag & Translat Res Zhejiang Prov, Affiliated Hosp 1, Wenzhou, Zhejiang, Peoples R China;
6.Iran Univ Med Sci, Cellular & Mol Res Ctr, Tehran 1449614535, Iran;
7.Nankai Univ, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China
第一作者单位附属第一医院;  口腔医学院、附属口腔医院;  正畸科
通讯作者单位附属第一医院
第一作者的第一单位附属第一医院
推荐引用方式
GB/T 7714
Hu, Xiaowen,Li, Dongdong,Li, Huaping,et al. Reaction-Induced Self-Assembly of Polymyxin Mitigates Cytotoxicity and Reverses Drug Resistance[J]. Advanced Materials,2024,36(36).
APA Hu, Xiaowen., Li, Dongdong., Li, Huaping., Piao, Yinzi., Wan, Hongping., ... & Liu, Yong. (2024). Reaction-Induced Self-Assembly of Polymyxin Mitigates Cytotoxicity and Reverses Drug Resistance. Advanced Materials, 36(36).
MLA Hu, Xiaowen,et al."Reaction-Induced Self-Assembly of Polymyxin Mitigates Cytotoxicity and Reverses Drug Resistance".Advanced Materials 36.36(2024).

条目包含的文件

条目无相关文件。
个性服务
查看访问统计
谷歌学术
谷歌学术中相似的文章
[Hu, Xiaowen]的文章
[Li, Dongdong]的文章
[Li, Huaping]的文章
百度学术
百度学术中相似的文章
[Hu, Xiaowen]的文章
[Li, Dongdong]的文章
[Li, Huaping]的文章
必应学术
必应学术中相似的文章
[Hu, Xiaowen]的文章
[Li, Dongdong]的文章
[Li, Huaping]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。