Biofilm-producing ability of methicillin-resistant Staphylococcus aureus clinically isolated in China

doi:10.1186/s12866-024-03380-8

科研成果详情

题名	Biofilm-producing ability of methicillin-resistant Staphylococcus aureus clinically isolated in China
作者	Jingyi Yu 1; Weihua Han 1; Yanlei Xu 1; Li Shen 1; Huilin Zhao 1; Jiao Zhang 2; Yanghua Xiao 3; Yinjuan Guo 1; Fangyou Yu 4
发表日期	2024-07-03
发表期刊	BMC Microbiology 影响因子和分区
语种	英语
原始文献类型	Journal Article
关键词	Adhesion genes Biofilm Methicillin-resistant Staphylococcus aureus
其他关键词	ELASTIN-BINDING PROTEIN ; ANTIBIOTIC-RESISTANCE ; BACTERIAL BIOFILMS ; STRAINS ; FIBRONECTIN ; EXPRESSION ; FIBRINOGEN ; VIRULENCE ; ADHESION ; GENES
摘要	Staphylococcus aureus, a commensal bacterium, colonizes the skin and mucous membranes of approximately 30% of the human population. Apart from conventional resistance mechanisms, one of the pathogenic features of S. aureus is its ability to survive in a biofilm state on both biotic and abiotic surfaces. Due to this characteristic, S. aureus is a major cause of human infections, with Methicillin-Resistant Staphylococcus aureus (MRSA) being a significant contributor to both community-acquired and hospital-acquired infections., Analyzing non-repetitive clinical isolates of MRSA collected from seven provinces and cities in China between 2014 and 2020, it was observed that 53.2% of the MRSA isolates exhibited varying degrees of ability to produce biofilm. The biofilm positivity rate was notably high in MRSA isolates from Guangdong, Jiangxi, and Hubei. The predominant MRSA strains collected in this study were of sequence types ST59, ST5, and ST239, with the biofilm-producing capability mainly distributed among moderate and weak biofilm producers within these ST types. Notably, certain sequence types, such as ST88, exhibited a high prevalence of strong biofilm-producing strains. The study found that SCCmec IV was the predominant type among biofilm-positive MRSA, followed by SCCmec II. Comparing strains with weak and strong biofilm production capabilities, the positive rates of the sdrD and sdrE were higher in strong biofilm producers. The genetic determinants ebp, icaA, icaB, icaC, icaD, icaR, and sdrE were associated with strong biofilm production in MRSA. Additionally, biofilm-negative MRSA isolates showed higher sensitivity rates to cefalotin (94.8%), daptomycin (94.5%), mupirocin (86.5%), teicoplanin (94.5%), fusidic acid (81.0%), and dalbavancin (94.5%) compared to biofilm-positive MRSA isolates. The biofilm positivity rate was consistently above 50% in all collected specimen types., MRSA strains with biofilm production capability warrant increased vigilance.
资助项目	Natural Science Fund of China [82202587]
出版者	BMC
ISSN	1471-2180
卷号	24 期号:1
DOI	10.1186/s12866-024-03380-8
页数	9
WOS类目	Microbiology
WOS研究方向	Microbiology
WOS记录号	WOS:001262601700002
收录类别	PUBMED ; SCIE ; SCOPUS
URL	查看原文
PubMed ID	38961344
SCOPUSEID	2-s2.0-85197407268
通讯作者地址	[Yu, Fangyou]Tongji Univ, Shanghai Pulm Hosp, Sch Med, Dept Clin Lab, Shanghai, Peoples R China.
Scopus学科分类	Microbiology;Microbiology (medical)
SCOPUS_ID	SCOPUS_ID:85197407268
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/215684
专题	附属第一医院第一临床医学院（信息与工程学院）、附属第一医院第一临床医学院（信息与工程学院）、附属第一医院_临床检验诊断学
作者单位	1.Department of Clinical Laboratory, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China.; 2.Department of Clinical Laboratory, Key Laboratory of Clinical Laboratory Diagnosis and Translational Research of Zhejiang Province, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.; 3.School of Public Health, Nanchang University, Nanchang, Jiangxi, China.; 4.Department of Clinical Laboratory, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai, China. wzjxyfy@163.com.
推荐引用方式 GB/T 7714	Jingyi Yu,Weihua Han,Yanlei Xu,et al. Biofilm-producing ability of methicillin-resistant Staphylococcus aureus clinically isolated in China[J]. BMC Microbiology,2024,24(1).
APA	Jingyi Yu., Weihua Han., Yanlei Xu., Li Shen., Huilin Zhao., ... & Fangyou Yu. (2024). Biofilm-producing ability of methicillin-resistant Staphylococcus aureus clinically isolated in China. BMC Microbiology, 24(1).
MLA	Jingyi Yu,et al."Biofilm-producing ability of methicillin-resistant Staphylococcus aureus clinically isolated in China".BMC Microbiology 24.1(2024).