Research progress of ubiquitin and ubiquitin-like signaling in Toxoplasma gondii

doi:10.1016/j.actatropica.2024.107283

科研成果详情

题名	Research progress of ubiquitin and ubiquitin-like signaling in Toxoplasma gondii
作者	Qi-Xin Zhou1; Si-Yu Tian1; Xiao-Na Liu1; Shi-Peng Xiang1; Xue-Jing Lin1; Feng Tan1; Ya-Ni Mou2
发表日期	2024-06-30
发表期刊	Acta Tropica 影响因子和分区
语种	英语
原始文献类型	Journal Article ; Review
关键词	Deubiquitinating enzyme Toxoplasma gondii Ubiquitin ligase (E3) Ubiquitin signaling Ubiquitin-conjugating enzyme (E2) Ubiquitin-like proteins, Ubiquitin-activating enzyme (E1)
其他关键词	DEUBIQUITINATING ENZYME ; PROTEIN ; DEGRADATION ; PROTEASOME ; MEMBRANE ; LIGASES ; NEDD8 ; PATHOGEN ; EXOSOMES ; SYSTEMS
摘要	Toxoplasmosis, a zoonotic parasitic disease caused by Toxoplasma gondii (T. gondii), is prevalent worldwide. The fact should be emphasized that a considerable proportion of individuals infected with T. gondii may remain asymptomatic; nevertheless, the condition can have severe implications for pregnant women or immunocompromised individuals. The current treatment of toxoplasmosis primarily relies on medication; however, traditional anti-toxoplasmosis drugs exhibit significant limitations in terms of efficacy, side effects, and drug resistance. The life cycles of T. gondii are characterized by distinct stages and its body morphology goes through dynamic alterations during the growth cycle that are intricately governed by a wide array of post-translational modifications (PTMs). Ubiquitin (Ub) signaling and ubiquitin-like (Ubl) signaling are two crucial post-translational modification pathways within cells, regulating protein function, localization, stability, or interactions by attaching Ub or ubiquitin-like proteins (Ubls) to target proteins. While these signaling mechanisms share some functional similarities, they have distinct regulatory mechanisms and effects. T. gondii possesses both Ub and Ubls and plays a significant role in regulating the parasite's life cycle and maintaining its morphology through PTMs of substrate proteins. Investigating the role and mechanism of protein ubiquitination in T. gondii will provide valuable insights for preventing and treating toxoplasmosis. This review explores the distinctive characteristics of Ub and Ubl signaling in T. gondii, with the aim of inspiring research ideas for the identification of safer and more effective drug targets against toxoplasmosis.
资助项目	National Natural Science Foundation of China [81971962, 82172303, 82372282]; Key Project of Natural Science Foundation of Zhejiang Province [LZ22H190001]; Talent Project of Wenzhou Medical University [89222021]
出版者	ELSEVIER
ISSN	0001-706X
EISSN	1873-6254
卷号	257
DOI	10.1016/j.actatropica.2024.107283
页数	9
WOS类目	Parasitology ; Tropical Medicine
WOS研究方向	Parasitology ; Tropical Medicine
WOS记录号	WOS:001265793600001
收录类别	PUBMED ; SCIE ; SCOPUS
URL	查看原文
PubMed ID	38955322
SCOPUSEID	2-s2.0-85197393631
通讯作者地址	[Mou, Ya-ni]Wenzhou Med Univ, Sch Basic Med Sci, Dept Parasitol, Wenzhou 325035, Zhejiang, Peoples R China.
Scopus学科分类	Parasitology;Infectious Diseases
SCOPUS_ID	SCOPUS_ID:85197393631
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/215671
专题	基础医学院（机能实验教学中心）_病原生物学与免疫学系_医学寄生虫学
作者单位	1.Department of Parasitology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou 325035, Zhejiang, PR China.; 2.Department of Parasitology, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou 325035, Zhejiang, PR China. Electronic address: mouyaniq@163.com.
第一作者单位	基础医学院（机能实验教学中心）_病原生物学与免疫学系_医学寄生虫学
通讯作者单位	基础医学院（机能实验教学中心）_病原生物学与免疫学系_医学寄生虫学
第一作者的第一单位	基础医学院（机能实验教学中心）_病原生物学与免疫学系_医学寄生虫学
推荐引用方式 GB/T 7714	Qi-Xin Zhou,Si-Yu Tian,Xiao-Na Liu,et al. Research progress of ubiquitin and ubiquitin-like signaling in Toxoplasma gondii[J]. Acta Tropica,2024,257.
APA	Qi-Xin Zhou., Si-Yu Tian., Xiao-Na Liu., Shi-Peng Xiang., Xue-Jing Lin., ... & Ya-Ni Mou. (2024). Research progress of ubiquitin and ubiquitin-like signaling in Toxoplasma gondii. Acta Tropica, 257.
MLA	Qi-Xin Zhou,et al."Research progress of ubiquitin and ubiquitin-like signaling in Toxoplasma gondii".Acta Tropica 257(2024).