Promising roles of combined therapy based on immune response and iron metabolism in systemic lupus erythematosus

doi:10.1016/j.intimp.2024.112481

科研成果详情

题名	Promising roles of combined therapy based on immune response and iron metabolism in systemic lupus erythematosus
作者	Xing, Zhouhang1; Gao, Sheng 2; Zheng, Anzhe 3; Tong, Chuyan 3; Fang, Yuan 3; Xiang, Zheng 3; Chen, Siyan4; Wang, Wenqian5; Hua, Chunyan1
发表日期	2024-09-10
发表期刊	International Immunopharmacology 影响因子和分区
语种	英语
原始文献类型	Review
关键词	Drug Immune cell Immunomodulation Iron metabolism Systemic lupus erythematosus
其他关键词	RENAL-FAILURE ; T-CELLS ; HOMEOSTASIS ; PATHOGENESIS ; TRANSFERRIN ; FERROPTOSIS ; DEFICIENCY ; EXCRETION ; NEPHRITIS ; LIPOCALIN
摘要	Systemic lupus erythematosus (SLE) is an intricate autoimmune disease with diverse manifestations. Immunometabolism reprogramming contributes to the progression of SLE by regulating the phenotype and function of immune cells. Dysregulated iron metabolism is implicated in SLE pathogenesis, affecting both systemic and immune cell-specific iron homeostasis. This review explores the systemic and cellular iron handling and regulation. Additionally, the advancements regarding iron metabolism in SLE with a focus on the distinct subsets of immune cells are highlighted. By gaining insight into the interplay between iron dysregulation and immune dysfunction, the potential therapeutic avenues may be unveiled. However, challenges remain in elucidating cell-specific iron metabolic reprogramming and its contribution to SLE pathogenesis needs further research for personalized therapeutic interventions and biomarker discovery. This review provides an in-depth understanding of immune cell-specific regulatory mechanisms of iron metabolism and new insights in current challenges as well as possible clinical applications.
资助项目	Science and Technology Plan Project of Wenzhou Municipality, China[Y20220045,Y20220389];Major Science & Technology Innovation Project of Wenzhou, China[ZY2022017];Zhejiang Province Natural Science Foundation of China[LTGY23H100001];National Natural Science Foundation of China[81901660]
出版者	Elsevier B.V.
ISSN	1567-5769
EISSN	1878-1705
卷号	138
DOI	10.1016/j.intimp.2024.112481
页数	9
WOS类目	Immunology ; Pharmacology & Pharmacy
WOS研究方向	Immunology ; Pharmacology & Pharmacy
WOS记录号	WOS:001260006000001
收录类别	SCOPUS ; PUBMED ; SCIE
URL	查看原文
PubMed ID	38917527
SCOPUSEID	2-s2.0-85196835670
通讯作者地址	[Wang, Wenqian]Department of Surgery,The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,Zhejiang Province,Wenzhou,325035,China
Scopus学科分类	Immunology and Allergy;Immunology;Pharmacology
SCOPUS_ID	SCOPUS_ID:85196835670
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/215568
专题	基础医学院（机能实验教学中心）温州医科大学第二临床医学院，附属第二医院、育英儿童医院实验动物中心
通讯作者	Wang, Wenqian; Hua, Chunyan
作者单位	1.School of Basic Medical Sciences,Wenzhou Medical University,Zhejiang Province,Wenzhou,325035,China; 2.Laboratory Animal Center,Wenzhou Medical University,Zhejiang Province,Wenzhou,325035,China; 3.School of the 2nd Clinical Medical Sciences,Wenzhou Medical University,Zhejiang Province,Wenzhou,325035,China; 4.School of Ophthalmology and Optometry,School of Biomedical Engineering,Wenzhou Medical University,Zhejiang Province,Wenzhou,325035,China; 5.Department of Surgery,The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,Zhejiang Province,Wenzhou,325035,China
第一作者单位	基础医学院（机能实验教学中心）
通讯作者单位	第二临床医学院，附属第二医院、育英儿童医院
第一作者的第一单位	基础医学院（机能实验教学中心）
推荐引用方式 GB/T 7714	Xing, Zhouhang,Gao, Sheng,Zheng, Anzhe,et al. Promising roles of combined therapy based on immune response and iron metabolism in systemic lupus erythematosus[J]. International Immunopharmacology,2024,138.
APA	Xing, Zhouhang., Gao, Sheng., Zheng, Anzhe., Tong, Chuyan., Fang, Yuan., ... & Hua, Chunyan. (2024). Promising roles of combined therapy based on immune response and iron metabolism in systemic lupus erythematosus. International Immunopharmacology, 138.
MLA	Xing, Zhouhang,et al."Promising roles of combined therapy based on immune response and iron metabolism in systemic lupus erythematosus".International Immunopharmacology 138(2024).