Bi-directional two-sample Mendelian randomization identifies causal association of depression with temporomandibular disorders

doi:10.1111/joor.13771

科研成果详情

题名	Bi-directional two-sample Mendelian randomization identifies causal association of depression with temporomandibular disorders
作者	Que, Hanxin1; Zhang, Qinglian1; Xu, Shengming1; Chu, Tengda2; Xu, Leyan 1; Wang, Yi 1
发表日期	2024-07-01
发表期刊	Journal of Oral Rehabilitation 影响因子和分区
语种	英语
原始文献类型	Article ; Early Access
关键词	anxiety depression genetic variant Mendelian randomization temporomandibular disorder
其他关键词	MULTIPLE GENETIC-VARIANTS ; RISK ; PREVALENCE ; SYMPTOMS ; ROBUST ; PAIN
摘要	Background: Depression and anxiety have been suggested to be associated with temporomandibular disorders (TMD) in observational studies. However, the causal association and the direction in the relationship between depression/anxiety and TMD remain unknown. Objectives: This study investigated the potential causal relationship between depression/anxiety and TMD with two-sample bi-directional Mendelian randomization (MR). Methods: Summary statistics of depression (N = 500 199), anxiety disorder (N = 17 310) and TMD (N = 195 930) were sourced from large-scale genome-wide association studies (GWAS). The primary Mendelian randomization (MR) estimation employed the inverse-variance weighted meta-analysis (IVW). Additional MR sensitivity methods and multivariate MR (MVMR) were applied to address pleiotropy. ResultsIVW results indicated a causal effect of genetically predicted depression on TMD (OR = 1.887, 95% CI = 1.504-2.367, p < .001), which was supported by other sensitivity MR approaches. MVMR results suggested that the negative effect of depression on TMD persisted after conditioning on other potential confounders. The association of anxiety disorder with TMD was not supported by our findings. In the reverse direction, we did not find compelling evidence suggesting the causal effect of TMD on depression and anxiety disorder. Conclusions: The present study suggests a potential causal association between genetic liability for depression and the risk of TMD. Our MR findings align with prior epidemiological research, underscoring the significance of early detection and prevention of depression in the treatment of TMD.
资助项目	Natural Science Foundation of Zhejiang Province [Y24H140017]; Provincial Program for the Cultivation of High-level Innovative Health Talents
出版者	WILEY
ISSN	0305-182X
EISSN	1365-2842
卷号	51 期号:9 页码:1653-1661
DOI	10.1111/joor.13771
页数	9
WOS类目	Dentistry, Oral Surgery & Medicine
WOS研究方向	Dentistry, Oral Surgery & Medicine
WOS记录号	WOS:001260152200001
收录类别	SCIE ; SCOPUS ; PUBMED
URL	查看原文
PubMed ID	38951129
SCOPUSEID	2-s2.0-85197241687
通讯作者地址	[Wang, Yi]Wenzhou Med Univ, Sch & Hosp Stomatol, Dept Orthodont, Wenzhou, Zhejiang, Peoples R China.
Scopus学科分类	Dentistry (all)
SCOPUS_ID	SCOPUS_ID:85197241687
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/215325
专题	口腔医学院、附属口腔医院口腔医学院、附属口腔医院_正畸科
通讯作者	Wang, Yi
作者单位	1.Wenzhou Med Univ, Sch & Hosp Stomatol, Dept Orthodont, Wenzhou, Zhejiang, Peoples R China; 2.Wenzhou Med Univ, Sch & Hosp Stomatol, Dept Periodontol, Wenzhou, Zhejiang, Peoples R China
第一作者单位	口腔医学院、附属口腔医院; 正畸科
通讯作者单位	口腔医学院、附属口腔医院; 正畸科
第一作者的第一单位	口腔医学院、附属口腔医院
推荐引用方式 GB/T 7714	Que, Hanxin,Zhang, Qinglian,Xu, Shengming,et al. Bi-directional two-sample Mendelian randomization identifies causal association of depression with temporomandibular disorders[J]. Journal of Oral Rehabilitation,2024,51(9):1653-1661.
APA	Que, Hanxin, Zhang, Qinglian, Xu, Shengming, Chu, Tengda, Xu, Leyan, & Wang, Yi. (2024). Bi-directional two-sample Mendelian randomization identifies causal association of depression with temporomandibular disorders. Journal of Oral Rehabilitation, 51(9), 1653-1661.
MLA	Que, Hanxin,et al."Bi-directional two-sample Mendelian randomization identifies causal association of depression with temporomandibular disorders".Journal of Oral Rehabilitation 51.9(2024):1653-1661.