Acid Neutralization by Composite Lysine Nanoparticles for Spinal Cord Injury Recovery through Mitigating Mitochondrial Dysfunction

doi:10.1021/acsbiomaterials.4c00612

科研成果详情

题名	Acid Neutralization by Composite Lysine Nanoparticles for Spinal Cord Injury Recovery through Mitigating Mitochondrial Dysfunction
作者	Wang, Qiuchen1,2; Ge, Lu 1; Guo, Jiali1; Zhang, Haijuan1; Chen, Tianling1; Lian, Feifei1; Li, Lei 3; Xu, Yun1; Xu, Jinyu1; Chen, Nuo 1; Zhang, Yu1; Ruan, Zhanwei4; Xiao, Jian1,2; Zhang, Hongyu1,2,5; Yang, Liangliang1,2
发表日期	2024-06-17
发表期刊	ACS BIOMATERIALS SCIENCE & ENGINEERING 影响因子和分区
语种	英语
原始文献类型	Article ; Early Access
关键词	Spinal cord injury Acidic microenvironment Mitochondrial dysfunction Lysine Hydrogel
其他关键词	PROTON CHANNEL HV1 ; HYDROGEL ; PH
摘要	After spinal cord injury (SCI), significant alterations in the tissue microenvironment lead to mitochondrial dysfunction, inducing apoptosis and inhibiting the remodeling of neural circuits, thereby impeding recovery. Although previous studies have demonstrated a marked decrease in pH at the injury site, creating an acidic microenvironment, the impact of improving this acidic microenvironment on SCI recovery has not been investigated. This study prepared a lysine@hollow mesoporous silica nanoparticle/gelatin methacrylate (GelMA) (L@H/G) composite hydrogel. The L@H/G composite hydrogel was demonstrated to release lysine and efficiently improve the acidic microenvironment slowly. Significantly, the composite hydrogel reduced cell apoptosis, promoted nerve regeneration, inhibited glial scar formation, and ultimately enhanced motor function recovery in mice with SCI. Mechanistically, the L@H/G hydrogel improved the mitochondrial tricarboxylic acid (TCA) cycle and fatty acid metabolism, restoring energy supply and facilitating mitochondrial function recovery. To the best of our knowledge, this is the first report confirming that improving the acidic microenvironment could promote SCI repair, providing a potential therapeutic strategy for SCI.
资助项目	Zhejiang Provincial Medical and Health Technology Plan Project [2023RC198, 2021KY1082]; Natural Science Foundation of Zhejiang Province [LY23H060004]; Natural Science Foundation of Ningbo [2022J044, 2023J255]; Ningbo Major Science and Technology Research Project [2022Z146]
出版者	AMER CHEMICAL SOC
ISSN	2373-9878
EISSN	2373-9878
卷号	10 期号:7 页码:4480-4495
DOI	10.1021/acsbiomaterials.4c00612
页数	16
WOS类目	Materials Science, Biomaterials
WOS研究方向	Materials Science
WOS记录号	WOS:001249627000001
收录类别	SCIE ; SCOPUS ; EI ; PUBMED
EI入藏号	20242616315908
EI主题词	Recovery
EI分类号	461.2 Biological Materials and Tissue Engineering ; 461.5 Rehabilitation Engineering and Assistive Technology ; 461.9 Biology ; 761 Nanotechnology ; 801.3 Colloid Chemistry ; 804 Chemical Products Generally ; 804.1 Organic Compounds
URL	查看原文
PubMed ID	38885615
SCOPUSEID	2-s2.0-85196635690
通讯作者地址	[Xiao, Jian;Zhang, Hongyu;Yang, Liangliang]Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou 325035, Zhejiang, Peoples R China. ; [Xiao, Jian;Zhang, Hongyu;Yang, Liangliang]Wenzhou Med Univ, Cixi Biomed Res Inst, Ningbo 315302, Zhejiang, Peoples R China. ; [Zhang, Hongyu]Wenzhou Med Univ, Lishui Peoples Hosp, Cent Lab, Lishui 323000, Zhejiang, Peoples R China.
Scopus学科分类	Biomaterials;Biomedical Engineering
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/215297
专题	药学院（分析测试中心）研究生工作部（研究生院）其他_温州市第三临床学院（温州市人民医院）其他_附属第三医院（瑞安市人民医院）其他_附属第六医院（丽水市人民医院）其他_温州医科大学慈溪生物医药研究院
通讯作者	Xiao, Jian; Zhang, Hongyu; Yang, Liangliang
作者单位	1.Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou 325035, Zhejiang, Peoples R China; 2.Wenzhou Med Univ, Cixi Biomed Res Inst, Ningbo 315302, Zhejiang, Peoples R China; 3.Ningbo 6 Hosp, Sci & Teaching Affairs Sect, Ningbo 315040, Zhejiang, Peoples R China; 4.Wenzhou Med Univ, Affiliated Hosp 3, Dept Emergency, Wenzhou 325200, Zhejiang, Peoples R China; 5.Wenzhou Med Univ, Lishui Peoples Hosp, Cent Lab, Lishui 323000, Zhejiang, Peoples R China
第一作者单位	药学院（分析测试中心）; 温州医科大学慈溪生物医药研究院
通讯作者单位	药学院（分析测试中心）; 温州医科大学慈溪生物医药研究院; 附属第六医院（丽水市人民医院）
第一作者的第一单位	药学院（分析测试中心）
推荐引用方式 GB/T 7714	Wang, Qiuchen,Ge, Lu,Guo, Jiali,et al. Acid Neutralization by Composite Lysine Nanoparticles for Spinal Cord Injury Recovery through Mitigating Mitochondrial Dysfunction[J]. ACS BIOMATERIALS SCIENCE & ENGINEERING,2024,10(7):4480-4495.
APA	Wang, Qiuchen., Ge, Lu., Guo, Jiali., Zhang, Haijuan., Chen, Tianling., ... & Yang, Liangliang. (2024). Acid Neutralization by Composite Lysine Nanoparticles for Spinal Cord Injury Recovery through Mitigating Mitochondrial Dysfunction. ACS BIOMATERIALS SCIENCE & ENGINEERING, 10(7), 4480-4495.
MLA	Wang, Qiuchen,et al."Acid Neutralization by Composite Lysine Nanoparticles for Spinal Cord Injury Recovery through Mitigating Mitochondrial Dysfunction".ACS BIOMATERIALS SCIENCE & ENGINEERING 10.7(2024):4480-4495.