Altered vaginal cervical microbiota diversity contributes to HPV-induced cervical cancer via inflammation regulation

doi:10.7717/peerj.17415

科研成果详情

题名	Altered vaginal cervical microbiota diversity contributes to HPV-induced cervical cancer via inflammation regulation
作者	Yang, Yiheng1; Zhu, Jufan1; Feng, Renqian1; Han, Mengfei1; Chen, Fenghua 2; Hu, Yan1
发表日期	2024-06-12
发表期刊	PEERJ 影响因子和分区
语种	英语
原始文献类型	Article
关键词	16S rRNA gene HPV Squamous intraepithelial lesions Vaginal microbiota
其他关键词	TH1/TH2
摘要	Background: Cancer has surpassed infectious diseases and heart ailments, taking the top spot in the disease hierarchy. Cervical cancer is a significant concern for women due to high incidence and mortality rates, linked to the human papillomavirus (HPV). HPV infection leads to precancerous lesions progressing to cervical cancer. The cervix's external os, near the vagina, hosts various microorganisms. Evidence points to the link between vaginal microbiota and HPV-induced cervical cancer. Cervical cancer onset aligns with an imbalanced Th1/Th2 immune response, but the role of vaginal microbiota in modulating this imbalance is unclear. Methods: In this study, we collected vaginal samples from 99 HPV-infected patients across varying degrees of lesions, alongside control groups. These samples underwent bacterial DNA sequencing. Additionally, we employed Elisa kits to quantify the protein expression levels of Th1/Th2 cytokines IL2, IL12, IL5, IL13, and TNFa within the centrifuged supernatant of vaginal -cervical secretions from diverse research subjects. Subsequently, correlation analyses were conducted between inflammatory factors and vaginal microbiota. Results: Our findings highlighted a correlation between decreased Lactobacillus and increased Gardenerella presence with HPV-induced cervical cancer. Functionally, our predictive analysis revealed the predominant enrichment of the ABC transporter within the vaginal microbiota of cervical cancer patients. Notably, these microbiota alterations exhibited correlations with the production of Th1/Th2 cytokines, which are intimately tied to tumor immunity. Conclusions: This study suggests the potential involvement of vaginal microbiota in the progression of HPV-induced cervical cancer through Th1/Th2 cytokine regulation. This novel insight offers a fresh perspective for early cervical cancer diagnosis and future prevention strategies.
资助项目	Department of Zhejiang Provincial Natural Science Foundation of China [Y19H040024]
出版者	PEERJ INC
ISSN	2167-8359
卷号	12 期号:6
DOI	10.7717/peerj.17415
页数	17
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
WOS记录号	WOS:001245216300001
收录类别	SCIE ; SCOPUS ; PUBMED
URL	查看原文
PubMed ID	38881859
SCOPUSEID	2-s2.0-85196154934
通讯作者地址	[Hu, Yan]Wenzhou Med Univ, Affiliated Hosp 1, Dept Obstet & Gynecol, Wenzhou, Peoples R China.
Scopus学科分类	Neuroscience (all);Biochemistry, Genetics and Molecular Biology (all);Agricultural and Biological Sciences (all)
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/215295
专题	附属第一医院_产科
通讯作者	Hu, Yan
作者单位	1.Wenzhou Med Univ, Affiliated Hosp 1, Dept Obstet & Gynecol, Wenzhou, Peoples R China; 2.Yiwu Cent Hosp, Dept Gastroenterol, Yiwu, Peoples R China
第一作者单位	附属第一医院_产科
通讯作者单位	附属第一医院_产科
第一作者的第一单位	附属第一医院_产科
推荐引用方式 GB/T 7714	Yang, Yiheng,Zhu, Jufan,Feng, Renqian,et al. Altered vaginal cervical microbiota diversity contributes to HPV-induced cervical cancer via inflammation regulation[J]. PEERJ,2024,12(6).
APA	Yang, Yiheng, Zhu, Jufan, Feng, Renqian, Han, Mengfei, Chen, Fenghua, & Hu, Yan. (2024). Altered vaginal cervical microbiota diversity contributes to HPV-induced cervical cancer via inflammation regulation. PEERJ, 12(6).
MLA	Yang, Yiheng,et al."Altered vaginal cervical microbiota diversity contributes to HPV-induced cervical cancer via inflammation regulation".PEERJ 12.6(2024).