题名 | Small extracellular vesicles derived from human induced pluripotent stem cell-differentiated neural progenitor cells mitigate retinal ganglion cell degeneration in a mouse model of optic nerve injury |
作者 | |
发表日期 | 2025-02-01 |
发表期刊 | Neural regeneration research 影响因子和分区 |
语种 | 英语 |
原始文献类型 | Journal Article |
关键词 | exosome miRNA neural progenitor cell neurodegeneration neuroinflammation neuroprotection optic nerve crush optic neuropathy retinal ganglion cell small extracellular vesicles |
其他关键词 | PROMOTE ; REGENERATION ; SURVIVAL ; THERAPY ; SYSTEM |
摘要 | JOURNAL/nrgr/04.03/01300535-202502000-00034/figure1/v/2024-05-28T214302Z/r/image-tiff Several studies have found that transplantation of neural progenitor cells (NPCs) promotes the survival of injured neurons. However, a poor integration rate and high risk of tumorigenicity after cell transplantation limits their clinical application. Small extracellular vesicles (sEVs) contain bioactive molecules for neuronal protection and regeneration. Previous studies have shown that stem/progenitor cell-derived sEVs can promote neuronal survival and recovery of neurological function in neurodegenerative eye diseases and other eye diseases. In this study, we intravitreally transplanted sEVs derived from human induced pluripotent stem cells (hiPSCs) and hiPSCs-differentiated NPCs (hiPSC-NPC) in a mouse model of optic nerve crush. Our results show that these intravitreally injected sEVs were ingested by retinal cells, especially those localized in the ganglion cell layer. Treatment with hiPSC-NPC-derived sEVs mitigated optic nerve crush-induced retinal ganglion cell degeneration, and regulated the retinal microenvironment by inhibiting excessive activation of microglia. Component analysis further revealed that hiPSC-NPC derived sEVs transported neuroprotective and anti-inflammatory miRNA cargos to target cells, which had protective effects on RGCs after optic nerve injury. These findings suggest that sEVs derived from hiPSC-NPC are a promising cell-free therapeutic strategy for optic neuropathy. |
资助项目 | National Natural Science Foundation of China [82271114]; Natural Science Foundation of Zhejiang Province of China [LZ22H120001] |
出版者 | WOLTERS KLUWER MEDKNOW PUBLICATIONS |
ISSN | 1673-5374 |
EISSN | 1876-7958 |
卷号 | 20期号:2页码:587-597 |
DOI | 10.4103/NRR.NRR-D-23-01414 |
页数 | 11 |
WOS类目 | Cell Biology ; Neurosciences |
WOS研究方向 | Cell Biology ; Neurosciences & Neurology |
WOS记录号 | WOS:001236392200006 |
收录类别 | PUBMED ; SCIE |
URL | 查看原文 |
Pubmed记录号 | 38819069 |
通讯作者地址 | [Chi, Zai-Long]Wenzhou Med Univ, Eye Hosp, State Key Lab Ophthalmol Optometry & Visual Sci, Wenzhou, Zhejiang, Peoples R China. ; [Chi, Zai-Long]Wenzhou Med Univ, Eye Hosp, Natl Clin Res Ctr Ocular Dis, Wenzhou, Zhejiang, Peoples R China. |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.wmu.edu.cn/handle/3ETUA0LF/215090 |
专题 | 眼视光学院(生物医学工程学院)、附属眼视光医院 |
作者单位 | 1.State Key Laboratory of Ophthalmology, Optometry and Visual Science, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang Province, China.; 2.National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang Province, China. |
第一作者单位 | 眼视光学院(生物医学工程学院)、附属眼视光医院 |
通讯作者单位 | 眼视光学院(生物医学工程学院)、附属眼视光医院 |
第一作者的第一单位 | 眼视光学院(生物医学工程学院)、附属眼视光医院 |
推荐引用方式 GB/T 7714 | Tong Li,Hui-Min Xing,Hai-Dong Qian,et al. Small extracellular vesicles derived from human induced pluripotent stem cell-differentiated neural progenitor cells mitigate retinal ganglion cell degeneration in a mouse model of optic nerve injury[J]. Neural regeneration research,2025,20(2):587-597. |
APA | Tong Li., Hui-Min Xing., Hai-Dong Qian., Qiao Gao., Sheng-Lan Xu., ... & Zai-Long Chi. (2025). Small extracellular vesicles derived from human induced pluripotent stem cell-differentiated neural progenitor cells mitigate retinal ganglion cell degeneration in a mouse model of optic nerve injury. Neural regeneration research, 20(2), 587-597. |
MLA | Tong Li,et al."Small extracellular vesicles derived from human induced pluripotent stem cell-differentiated neural progenitor cells mitigate retinal ganglion cell degeneration in a mouse model of optic nerve injury".Neural regeneration research 20.2(2025):587-597. |
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