Evaluation of the clinical application value of cytokine expression profiles in the differential diagnosis of prostate cancer

doi:10.1007/s00262-024-03723-4

科研成果详情

题名	Evaluation of the clinical application value of cytokine expression profiles in the differential diagnosis of prostate cancer
作者	Chen, Rongfa1; Liu, Linna1; Chen, Hui 1; Xing, Chao1; Zhang, Tingting 1; Pang, Yilin2; Yang, Xunjun1
发表日期	2024-06-04
发表期刊	CANCER IMMUNOLOGY IMMUNOTHERAPY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Prostatic Neoplasms Cytokines Blood Peripheral Luminex Technology
摘要	Background The significance of tumor-secreted cytokines in tumor development has gained substantial attention. Nevertheless, the precise role of tumor-related inflammatory cytokines in prostate cancer (PCa) remains ambiguous. Objectives To gain deeper insights into the inflammatory response in the process of PCa. Methods A total of 233 cases were collected, including 80 cases of prostate hyperplasia as disease control, 65 cases of postoperative prostate cancer and 36 cases of prostate cancer as PCa group. Additionally, 52 patients undergoing physical examinations during the same period were collected as the healthy control. The levels of 12 inflammatory cytokines in peripheral blood samples were analyzed using flow cytometric bead array technology. The levels of total prostate-specific antigen (TPSA) and free prostate-specific antigen (FPSA) in peripheral blood samples were analyzed using electrochemiluminescence technology. Results Our findings revealed significant increases in serum IL-8 levels in PCa group compared to the healthy control group. Additionally, IL-6, IL-10, IFN-gamma and IL-12p70 levels were markedly elevated in the PCa group compared to the disease control group (all p < 0.05). Conversely, the level of IL-4, TNF-alpha, IL-1 beta, IL-17A and IFN-alpha were lower in the PCa group compared to those in control group. Following surgery, the concentration of IL-6 decreased; whereas, the concentrations of IL-4, TNF-alpha, IL-17A, IL-1 beta, IL-12p70, and IFN-alpha increased, demonstrating significant differences (p < 0.05). The differential upregulation of IL-6 or downregulation of IL-17A in peripheral blood exhibited diagnostic efficacy in PCa patients. Moreover, we observed a significant increase in IL-17A levels, accompanied by decreased of IL-2, IL-4, IL-10, TNF-a, IFN-gamma, IL-1 beta, and IL-12P70 in patients with distant metastasis. Conclusion The peripheral blood cytokines are closely associated with the occurrence and development of prostate cancer, especially the serum levels of IL-6 and IL-17A may be useful as potential predictors of PCa diagnosis.
资助项目	Science and Technology Plan Project of Wenzhou [2022KY903]; Zhejiang Medical and Health Science and Technology Plan Project [Y20210725]; Science and Technology Plan Project of Wenzhou (Fund)
出版者	SPRINGER
ISSN	0340-7004
EISSN	1432-0851
卷号	73 期号:8
DOI	10.1007/s00262-024-03723-4
页数	9
WOS类目	Oncology ; Immunology
WOS研究方向	Oncology ; Immunology
WOS记录号	WOS:001239361300022
收录类别	SCIE ; SCOPUS ; PUBMED
URL	查看原文
PubMed ID	38833027
SCOPUSEID	2-s2.0-85194996208
通讯作者地址	[Yang, Xunjun]Wenzhou Med Univ, Dept Lab Med, Affiliated Hosp 2, Wenzhou 325000, Zhejiang, Peoples R China.
Scopus学科分类	Immunology and Allergy;Immunology;Oncology;Cancer Research
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/214702
专题	附属第二医院检验医学院（生命科学学院、生物学实验教学中心）第二临床医学院、附属第二医院、育英儿童医院附属第二医院_检验科
通讯作者	Yang, Xunjun
作者单位	1.Wenzhou Med Univ, Dept Lab Med, Affiliated Hosp 2, Wenzhou 325000, Zhejiang, Peoples R China; 2.WenZhou Med Univ, Sch Lab Med & Life Sci, Wenzhou 325035, Zhejiang, Peoples R China
第一作者单位	检验医学院（生命科学学院、生物学实验教学中心）; 附属第二医院; 第二临床医学院，附属第二医院、育英儿童医院; 检验科
通讯作者单位	检验医学院（生命科学学院、生物学实验教学中心）; 附属第二医院; 第二临床医学院，附属第二医院、育英儿童医院; 检验科
第一作者的第一单位	检验医学院（生命科学学院、生物学实验教学中心）
推荐引用方式 GB/T 7714	Chen, Rongfa,Liu, Linna,Chen, Hui,et al. Evaluation of the clinical application value of cytokine expression profiles in the differential diagnosis of prostate cancer[J]. CANCER IMMUNOLOGY IMMUNOTHERAPY,2024,73(8).
APA	Chen, Rongfa., Liu, Linna., Chen, Hui., Xing, Chao., Zhang, Tingting., ... & Yang, Xunjun. (2024). Evaluation of the clinical application value of cytokine expression profiles in the differential diagnosis of prostate cancer. CANCER IMMUNOLOGY IMMUNOTHERAPY, 73(8).
MLA	Chen, Rongfa,et al."Evaluation of the clinical application value of cytokine expression profiles in the differential diagnosis of prostate cancer".CANCER IMMUNOLOGY IMMUNOTHERAPY 73.8(2024).