PPIH acts as a potential predictive biomarker for patients with common solid tumors

doi:10.1186/s12885-024-12446-9

科研成果详情

题名	PPIH acts as a potential predictive biomarker for patients with common solid tumors
作者	Ye, Jun 1; Ying, Jianchao2; Chen, Haixia 3; Wu, Zhiping 1; Huang, Chaolin 4; Zhang, Chuan 5; Chen, Zhitao 5; Chen, Haini 1
发表日期	2024-06-04
发表期刊	BMC Cancer 影响因子和分区
语种	英语
原始文献类型	Article
关键词	PPIH Common solid tumors Predictive biomarker Combined diagnosis TCGA
其他关键词	CANCER STATISTICS ; CYCLOPHILIN ; EXPRESSION ; MUTATIONS ; PROTEINS
摘要	Background Our previous studies have indicated that mRNA and protein levels of PPIH are significantly upregulated in Hepatocellular Carcinoma (LIHC) and could act as predictive biomarkers for patients with LIHC. Nonetheless, the expression and implications of PPIH in the etiology and progression of common solid tumors have yet to be explored, including its potential as a serum tumor marker. Methods We employed bioinformatics analyses, augmented with clinical sample evaluations, to investigate the mRNA and protein expression and gene regulation networks of PPIH in various solid tumors. We also assessed the association between PPIH expression and overall survival (OS) in cancer patients using Kaplan-Meier analysis with TCGA database information. Furthermore, we evaluated the feasibility and diagnostic efficacy of PPIH as a serum marker by integrating serological studies with established clinical tumor markers. Results Through pan-cancer analysis, we found that the expression levels of PPIH mRNA in multiple tumors were significantly different from those in normal tissues. This study is the first to report that PPIH mRNA and protein levels are markedly elevated in LIHC, Colon adenocarcinoma (COAD), and Breast cancer (BC), and are associated with a worse prognosis in these cancer patients. Conversely, serum PPIH levels are decreased in patients with these tumors (LIHC, COAD, BC, gastric cancer), and when combined with traditional tumor markers, offer enhanced sensitivity and specificity for diagnosis. Conclusion Our findings propose that PPIH may serve as a valuable predictive biomarker in tumor patients, and its secreted protein could be a potential serum marker, providing insights into the role of PPIH in cancer development and progression.
资助项目	Guizhou Provincial Basic Research Program (Natural Science) (No. Basic of Guizhou Science Cooperation Foundation - ZK [2023] General 337)
出版者	BMC
ISSN	1471-2407
EISSN	1471-2407
卷号	24 期号:1
DOI	10.1186/s12885-024-12446-9
页数	13
WOS类目	Oncology
WOS研究方向	Oncology
WOS记录号	WOS:001239338800003
收录类别	SCIE ; SCOPUS ; PUBMED
URL	查看原文
PubMed ID	38834966
SCOPUSEID	2-s2.0-85195249785
通讯作者地址	[Chen, Haini]Guizhou Med Univ, Affiliated Hosp 2, Dept Clin Lab, Kaili 556000, Guizhou, Peoples R China.
Scopus学科分类	Oncology;Genetics;Cancer Research
SCOPUS_ID	SCOPUS_ID:85195249785
TOP期刊	TOP期刊
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/214625
专题	第一临床医学院（信息与工程学院）、附属第一医院_中心实验室
通讯作者	Chen, Haini
作者单位	1.Guizhou Med Univ, Affiliated Hosp 2, Dept Clin Lab, Kaili 556000, Guizhou, Peoples R China; 2.Wenzhou Med Univ, Affiliated Hosp 1, Cent Lab, Wenzhou Key Lab Emergency Crit Care & Disaster Med, Wenzhou, Peoples R China; 3.Guizhou Med Univ, Coll Lab Med, Guiyang 550001, Guizhou, Peoples R China; 4.Chengdu Med Coll, Affiliated Hosp 1, Dept Gynaecol, Chengdu, Peoples R China; 5.Guizhou Med Univ, Affiliated Hosp 2, Dept Pathol, Kaili 556000, Guizhou, Peoples R China
推荐引用方式 GB/T 7714	Ye, Jun,Ying, Jianchao,Chen, Haixia,et al. PPIH acts as a potential predictive biomarker for patients with common solid tumors[J]. BMC Cancer,2024,24(1).
APA	Ye, Jun., Ying, Jianchao., Chen, Haixia., Wu, Zhiping., Huang, Chaolin., ... & Chen, Haini. (2024). PPIH acts as a potential predictive biomarker for patients with common solid tumors. BMC Cancer, 24(1).
MLA	Ye, Jun,et al."PPIH acts as a potential predictive biomarker for patients with common solid tumors".BMC Cancer 24.1(2024).