Syringeable Near-Infrared Light-Activated In Situ Immunogenic Hydrogel Boosts the Cancer-Immunity Cycle to Enhance Anticancer Immunity

doi:10.1021/acsnano.3c08425

科研成果详情

题名	Syringeable Near-Infrared Light-Activated In Situ Immunogenic Hydrogel Boosts the Cancer-Immunity Cycle to Enhance Anticancer Immunity
作者	Fu, Yang 1,2; Zhu, Xiaoxiao 3; Ren, Lulu 1,4; Wan, Jianqin 1,4,5; Wang, Hangxiang 1,4,5,6
发表日期	2024-05-29
发表期刊	ACS NANO 影响因子和分区
语种	英语
原始文献类型	Article
关键词	syringeable hydrogel prodrug engineering local treatment cancer-immunity cycle cancervaccination
其他关键词	NANOPARTICLES PROMOTE ; CABAZITAXEL ; GEMCITABINE ; CELLS
摘要	Effective anticancer immunity depends on properly activating multiple stepwise events in the cancer-immunity cycle. An immunologically cold tumor microenvironment (TME) engenders immune evasion and refractoriness to conventional checkpoint blockade immunotherapy. Here, we combine nanoparticle formulations and an in situ formed hydrogel scaffold to treat accessible tumors locally and to stimulate systemic immunity against metastatic tumor lesions. The nanoparticles encapsulate poly(epsilon-caprolactone)-derived cytotoxic chemotherapy and adjuvant of Toll-like receptor 7/8 through a reactive oxygen species (ROS)-cleavable linker that can be self-activated by the coassembled neighboring photosensitizer following near-infrared (NIR) laser irradiation. Further development results in syringeable, NIR light-responsive, and immunogenic hydrogel (iGEL) that can be implanted peritumorally and deposited into the tumor surgical bed. Upon NIR laser irradiation, the generated ROS induces iGEL degradation and bond cleavage in the polymer-drug conjugates, triggering the immunogenic cell death cascade in cancer cells and spontaneously releasing encapsulated agents to rewire the cancer-immunity cycle. Notably, upon application in multiple preclinical models of melanoma and triple-negative breast cancer, which are aggressive and refractory to conventional immunotherapy, iGEL induces durable remission of established tumors, extends postsurgical tumor-free survival, and inhibits metastatic burden. The result of this study is a locally administrable immunogenic hydrogel for triggering host systemic immunity to improve immunotherapeutic efficacy with minimal off-target side effects.
资助项目	National Natural Science Foundation of China [82273490, 82073296, 81773193, 82303561]; National Natural Science Foundation of China [ZR2023ZD59]; Natural Science Foundation of Shandong Province [LR19H160002]; Zhejiang Provincial Natural Science Foundation of China [JNL-2022010B]; Research Project of Jinan Microecological Biomedicine Shandong Laboratory [BX20230313]; China National Postdoctoral Program for Innovative Talents
出版者	AMER CHEMICAL SOC
ISSN	1936-0851
EISSN	1936-086X
卷号	18 期号:23 页码:14877-14892
DOI	10.1021/acsnano.3c08425
页数	16
WOS类目	Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS研究方向	Chemistry ; Science & Technology - Other Topics ; Materials Science
WOS记录号	WOS:001235248600001
收录类别	SCIE ; SCOPUS ; PUBMED
URL	查看原文
PubMed ID	38809421
SCOPUSEID	2-s2.0-85195095142
通讯作者地址	[Wan, Jianqin;Wang, Hangxiang]Zhejiang Univ, Affiliated Hosp 1, Sch Med, Hangzhou 310003, Zhejiang, Peoples R China. ; [Wan, Jianqin;Wang, Hangxiang]Zhejiang Univ Sch Med, Key Lab Combined Multiorgan Transplantat, Minist Publ Hlth, Hangzhou 310003, Zhejiang, Peoples R China. ; [Wan, Jianqin;Wang, Hangxiang]Jinan Microecol Biomed Shandong Lab, Jinan 250117, Shandong, Peoples R China. ; [Wang, Hangxiang]Wenzhou Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Wenzhou 325000, Zhejiang, Peoples R China.
Scopus学科分类	Materials Science (all);Engineering (all);Physics and Astronomy (all)
TOP期刊	TOP期刊
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/214599
专题	附属第一医院_肝胆外科
通讯作者	Wan, Jianqin; Wang, Hangxiang
作者单位	1.Zhejiang Univ, Affiliated Hosp 1, Sch Med, Hangzhou 310003, Zhejiang, Peoples R China; 2.Zhejiang Univ, Collaborat Innovat Ctr Diag & Treatment Infect Dis, Sch Med, NHC Key Lab Combined Multiorgan Transplantat,State, Hangzhou 310003, Zhejiang, Peoples R China; 3.Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Dept Med Oncol, Hangzhou 310016, Zhejiang, Peoples R China; 4.Zhejiang Univ Sch Med, Key Lab Combined Multiorgan Transplantat, Minist Publ Hlth, Hangzhou 310003, Zhejiang, Peoples R China; 5.Jinan Microecol Biomed Shandong Lab, Jinan 250117, Shandong, Peoples R China; 6.Wenzhou Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Wenzhou 325000, Zhejiang, Peoples R China
通讯作者单位	附属第一医院_肝胆外科
推荐引用方式 GB/T 7714	Fu, Yang,Zhu, Xiaoxiao,Ren, Lulu,et al. Syringeable Near-Infrared Light-Activated In Situ Immunogenic Hydrogel Boosts the Cancer-Immunity Cycle to Enhance Anticancer Immunity[J]. ACS NANO,2024,18(23):14877-14892.
APA	Fu, Yang, Zhu, Xiaoxiao, Ren, Lulu, Wan, Jianqin, & Wang, Hangxiang. (2024). Syringeable Near-Infrared Light-Activated In Situ Immunogenic Hydrogel Boosts the Cancer-Immunity Cycle to Enhance Anticancer Immunity. ACS NANO, 18(23), 14877-14892.
MLA	Fu, Yang,et al."Syringeable Near-Infrared Light-Activated In Situ Immunogenic Hydrogel Boosts the Cancer-Immunity Cycle to Enhance Anticancer Immunity".ACS NANO 18.23(2024):14877-14892.