Relationship between the Number of Neutrophils and Myofibroblasts during Dia- betic Wound Healing and Wound Age

doi:10.12116/j.issn.1004-5619.2019.02.004

科研成果详情

题名	Relationship between the Number of Neutrophils and Myofibroblasts during Dia- betic Wound Healing and Wound Age
其他题名	糖尿病损伤愈合期间中性粒细胞及肌成纤维细胞数量与损伤时间的关系
作者	Huang, Jun-Jie1,2,3; Yao, Yi1,2,3; Xia, Chong-Jian1,2,3; Zhao, Ya-Di 1,2,3; Yu, Si 1,2,3; Gao, Yuan1,2,3; Ye, Guanghua1,2,3; Yu, Lin-Sheng1,2,3; Fan, Yan-Yan1,2,3
发表日期	2019-04-25
发表期刊	Journal of Forensic Medicine 影响因子和分区
语种	中文
原始文献类型	Article
关键词	Diabetes mellitus estimation Forensic pathology Mice Myofibroblast Neutrophil Wound age Wound healing
摘要	Objective To investigate the sequential changes of the number of neutrophils and myofibroblasts during diabetic wound healing, and discuss its application value in wound age estimation. Methods Diabetic DB mice and mice of the same age in the normal control group were selected, a wound healing model was established, wound samples were taken at different time points, while the number of neutrophils and myofibroblasts during diabetic wound healing were determined by immunohistochemical staining technique. Results The number of infiltrated neutrophils in the wounds of control and diabetic groups reached the peak respectively at 12 h and 5 d after injury. Compared with the control group, the number of neutrophils in the diabetic group decreased significantly from 6 h to 1 d after injury, but increased markedly from 5 d to 14 d. From 5 d to 10 d after injury, the average number of neutrophils at high magnification in wounds of the diabetic group was over 30, while that of neutrophils in wounds of the control group was less than 20. Myofibroblasts appeared in wounds from 3 d to 14 d after injury in the control group and from 5 d to 14 d after injury in the diabetic group. The difference in the number of myofibroblasts in wounds between control group and diabetic group from 3 to 7 d after injury had statistical significance. Conclusion In comparison with normal wound healing, the number of neutrophils and myofibroblasts during diabetic wound healing shows different sequential changes. The results of this study can provide reference for wound age estimation of patients with severe diabetes.
出版者	Journal of Forensic Medicinefyxzz@126.com
ISSN	1004-5619
卷号	35 期号:2 页码:149-153
DOI	10.12116/j.issn.1004-5619.2019.02.004
收录类别	SCOPUS
URL	查看原文
PubMed ID	31135107
SCOPUSEID	2-s2.0-85066447545
通讯作者地址	[Fan, Yan-Yan]Department of Forensic Medicine,Wenzhou Medical University,Wenzhou,325035,China
Scopus学科分类	Pathology and Forensic Medicine
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/214195
专题	基础医学院（机能实验教学中心）_法医学系
通讯作者	Fan, Yan-Yan
作者单位	1.Department of Forensic Medicine,Wenzhou Medical University,Wenzhou,325035,China; 2.Judical Forensic Center,Wenzhou Medical University,Wenzhou,325035,China; 3.Institute of Forensic Science,Wenzhou Medical University,Wenzhou,325035,China
第一作者单位	法医学系; 温州医科大学
通讯作者单位	法医学系
第一作者的第一单位	法医学系
推荐引用方式 GB/T 7714	Huang, Jun-Jie,Yao, Yi,Xia, Chong-Jian,et al. Relationship between the Number of Neutrophils and Myofibroblasts during Dia- betic Wound Healing and Wound Age[J]. Journal of Forensic Medicine,2019,35(2):149-153.
APA	Huang, Jun-Jie., Yao, Yi., Xia, Chong-Jian., Zhao, Ya-Di., Yu, Si., ... & Fan, Yan-Yan. (2019). Relationship between the Number of Neutrophils and Myofibroblasts during Dia- betic Wound Healing and Wound Age. Journal of Forensic Medicine, 35(2), 149-153.
MLA	Huang, Jun-Jie,et al."Relationship between the Number of Neutrophils and Myofibroblasts during Dia- betic Wound Healing and Wound Age".Journal of Forensic Medicine 35.2(2019):149-153.