Electroacupuncture improves neuropathic pain: Adenosine, adenosine 5’-triphosphate disodium and their receptors perhaps change simultaneously

科研成果详情

题名	Electroacupuncture improves neuropathic pain: Adenosine, adenosine 5’-triphosphate disodium and their receptors perhaps change simultaneously
作者	Ren, Wen 1; Tu, Wen Zhan 2; Jiang, Song He 2; Cheng, Rui Dong 2; Du, Ya Ping 1
发表日期	2012-09-25
发表期刊	Neural Regeneration Research 影响因子和分区
语种	英语
原始文献类型	Article
关键词	A1 receptors Adenosine Adenosine 5’-triphosphate disodium Analgesia Central nervous system Electroacupuncture Neural regeneration Neuropathic pain P2X purinoceptor 3 receptors Peripheral nervous system Regeneration
摘要	Applying a stimulating current to acupoints through acupuncture needles – known as electroacupuncture – has the potential to produce analgesic effects in human subjects and experimental animals. When acupuncture was applied in a rat model, adenosine 5’-triphosphate disodium in the extracellular space was broken down into adenosine, which in turn inhibited pain transmission by means of an adenosine A1 receptor-dependent process. Direct injection of an adenosine A1 receptor agonist enhanced the analgesic effect of acupuncture. The analgesic effect of acupuncture appears to be mediated by activation of A1 receptors located on ascending nerves. In neuropathic pain, there is upregulation of P2X purinoceptor 3 (P2X3) receptor expression in dorsal root ganglion neurons. Conversely, the onset of mechanical hyperalgesia was diminished and established hyperalgesia was significantly reversed when P2X3 receptor expression was downregulated. The pathways upon which electroacupuncture appear to act are interwoven with pain pathways, and electroacupuncture stimuli converge with impulses originating from painful areas. Electroacupuncture may act via purinergic A1 and P2X3 receptors simultaneously to induce an analgesic effect on neuropathic pain.
出版者	Editorial Board of Neural Regeneration Research
ISSN	1673-5374
EISSN	1876-7958
卷号	7 期号:33 页码:2607-2616
收录类别	SCOPUS
URL	查看原文
SCOPUSEID	2-s2.0-84925944317
通讯作者地址	[Du, Ya Ping]Institute of Social and Family Medicine,Zhejiang University,Hangzhou,310058,China
Scopus学科分类	Developmental Neuroscience
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/213628
专题	第二临床医学院，附属第二医院、育英儿童医院附属第二医院
通讯作者	Du, Ya Ping
作者单位	1.Institute of Social and Family Medicine,Zhejiang University,Hangzhou Zhejiang Province,310058,China; 2.Department of Physical Medicine and Rehabilitation,The Second Affiliated Hospital of Wenzhou Medical College,Wenzhou,325000,China
推荐引用方式 GB/T 7714	Ren, Wen,Tu, Wen Zhan,Jiang, Song He,et al. Electroacupuncture improves neuropathic pain: Adenosine, adenosine 5’-triphosphate disodium and their receptors perhaps change simultaneously[J]. Neural Regeneration Research,2012,7(33):2607-2616.
APA	Ren, Wen, Tu, Wen Zhan, Jiang, Song He, Cheng, Rui Dong, & Du, Ya Ping. (2012). Electroacupuncture improves neuropathic pain: Adenosine, adenosine 5’-triphosphate disodium and their receptors perhaps change simultaneously. Neural Regeneration Research, 7(33), 2607-2616.
MLA	Ren, Wen,et al."Electroacupuncture improves neuropathic pain: Adenosine, adenosine 5’-triphosphate disodium and their receptors perhaps change simultaneously".Neural Regeneration Research 7.33(2012):2607-2616.