Bee Venom-Loaded Niosomes as Innovative Platforms for Cancer Treatment: Development and Therapeutical Efficacy and Safety Evaluation

doi:10.3390/ph17050572

科研成果详情

题名	Bee Venom-Loaded Niosomes as Innovative Platforms for Cancer Treatment: Development and Therapeutical Efficacy and Safety Evaluation
作者	Pinto, Maria Beatriz 1; Pires, Patrícia C.1,2,3; Calhelha, Ricardo C.4,5; Silva, Ana Rita 4,5; Sousa, Maria João 4,5; Vilas-Boas, Miguel 4,5; Falcão, Soraia I.4,5; Veiga, Francisco 1,2; Makvandi, Pooyan 6,7,8; Paiva-Santos, Ana Cláudia 1,2
发表日期	2024-05-01
发表期刊	Pharmaceuticals; 影响因子和分区
语种	英语
原始文献类型	Article
关键词	anti-inflammatory anticancer antitumor bee venom in vitro nanosystems natural compounds niosomes
其他关键词	IN-VITRO ; DRUG-DELIVERY ; APIS-MELLIFERA ; HET-CAM ; INFLAMMATION ; IRRITATION ; CYTOTOXICITY ; FORMULATIONS ; ACUPUNCTURE ; ANTIOXIDANT
摘要	Despite past efforts towards therapeutical innovation, cancer remains a highly incident and lethal disease, with current treatments lacking efficiency and leading to severe side effects. Hence, it is imperative to develop new, more efficient, and safer therapies. Bee venom has proven to have multiple and synergistic bioactivities, including antitumor effects. Nevertheless, some toxic effects have been associated with its administration. To tackle these issues, in this work, bee venom-loaded niosomes were developed, for cancer treatment. The vesicles had a small (150 nm) and homogeneous (polydispersity index of 0.162) particle size, and revealed good therapeutic efficacy in in vitro gastric, colorectal, breast, lung, and cervical cancer models (inhibitory concentrations between 12.37 ng/mL and 14.72 ng/mL). Additionally, they also revealed substantial anti-inflammatory activity (inhibitory concentration of 28.98 ng/mL), effects complementary to direct antitumor activity. Niosome safety was also assessed, both in vitro (skin, liver, and kidney cells) and ex vivo (hen’s egg chorioallantoic membrane), and results showed that compound encapsulation increased its safety. Hence, small, and homogeneous bee venom-loaded niosomes were successfully developed, with substantial anticancer and anti-inflammatory effects, making them potentially promising primary or adjuvant cancer therapies. Future research should focus on evaluating the potential of the developed platform in in vivo models.
资助项目	Research and Development Project[2022.05270];MCTES[UIDB/00690/2020,UIDP/00690/2020,LA/P/0007/2021];
出版者	MDPI
ISSN	1424-8247
EISSN	1424-8247
卷号	17 期号:5
DOI	10.3390/ph17050572
页数	24
WOS类目	Chemistry, Medicinal ; Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
WOS记录号	WOS:001231579500001
收录类别	SCOPUS ; SCIE
URL	查看原文
PubMed ID	38794142
SCOPUSEID	2-s2.0-85194106366
通讯作者地址	[Pires, Patrícia C.]Department of Pharmaceutical Technology,Faculty of Pharmacy of the University of Coimbra,University of Coimbra,Azinhaga de Santa Comba,Coimbra,3000-548,Portugal ; [Paiva-Santos, Ana Cláudia]Department of Pharmaceutical Technology,Faculty of Pharmacy of the University of Coimbra,University of Coimbra,Azinhaga de Santa Comba,Coimbra,3000-548,Portugal
Scopus学科分类	Molecular Medicine;Pharmaceutical Science;Drug Discovery
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/213439
专题	其他_温州医科大学附属衢州医院
通讯作者	Pires, Patrícia C.; Paiva-Santos, Ana Cláudia
作者单位	1.Department of Pharmaceutical Technology,Faculty of Pharmacy of the University of Coimbra,University of Coimbra,Azinhaga de Santa Comba,Coimbra,3000-548,Portugal; 2.REQUIMTE/LAQV,Group of Pharmaceutical Technology,Faculty of Pharmacy of the University of Coimbra,University of Coimbra,Coimbra,3000-548,Portugal; 3.Health Sciences Research Centre (CICS-UBI),University of Beira Interior,Av. Infante D. Henrique,Covilhã,6200-506,Portugal; 4.Centro de Investigação de Montanha (CIMO),Instituto Politécnico de Bragança,Campus de Santa Apolónia,Bragança,5300-253,Portugal; 5.Laboratório Associado para a Sustentabilidade e Tecnologia em Regiões de Montanha (SusTEC),Instituto Politécnico de Bragança,Campus de Santa Apolónia,Bragança,5300-253,Portugal; 6.The Quzhou Affiliated Hospital of Wenzhou Medical University,Quzhou People’s Hospital,Quzhou,324000,China; 7.Centre of Research Impact and Outreach,Chitkara University,Rajpura,140417,India; 8.Department of Biomaterials,Saveetha Dental College and Hospitals,SIMATS,Saveetha University,Chennai,600077,India
推荐引用方式 GB/T 7714	Pinto, Maria Beatriz,Pires, Patrícia C.,Calhelha, Ricardo C.,et al. Bee Venom-Loaded Niosomes as Innovative Platforms for Cancer Treatment: Development and Therapeutical Efficacy and Safety Evaluation[J]. Pharmaceuticals;,2024,17(5).
APA	Pinto, Maria Beatriz., Pires, Patrícia C.., Calhelha, Ricardo C.., Silva, Ana Rita., Sousa, Maria João., ... & Paiva-Santos, Ana Cláudia. (2024). Bee Venom-Loaded Niosomes as Innovative Platforms for Cancer Treatment: Development and Therapeutical Efficacy and Safety Evaluation. Pharmaceuticals;, 17(5).
MLA	Pinto, Maria Beatriz,et al."Bee Venom-Loaded Niosomes as Innovative Platforms for Cancer Treatment: Development and Therapeutical Efficacy and Safety Evaluation".Pharmaceuticals; 17.5(2024).