题名 | Runx2 Suppresses Astrocyte Activation and Astroglial Scar Formation After Spinal Cord Injury in Mice |
作者 | |
发表日期 | 2024 |
发表期刊 | Molecular Neurobiology; 影响因子和分区 |
语种 | 英语 |
原始文献类型 | Article |
关键词 | Astrocytes Astroglial scar Nuclear-matrix-targeting signal Runx2 Spinal cord injury |
其他关键词 | APOPTOSIS |
摘要 | After spinal cord injury, astrocytes undergo a reactive process and form an astroglial scar, which impedes the regeneration of axons. The role of Runx2 in promoting the transformation of astrocytes in the central nervous system is well-established. However, it remains unclear whether Runx2 also plays a role in the development of astroglial scar, and the precise underlying mechanism has yet to be identified. Recently, our study using cell culture and animal models has demonstrated that Runx2 actually suppresses astrocyte activation and the formation of astroglial scar following injury. The initial results demonstrated an increase in the expression of Runx2 in astrocytes following in vivo injury. Subsequently, the overexpression of Runx2 resulted in the inhibition of astrocyte activation, reduction in the total area of astroglial scar, and restoration of neural function after 14 days of injury. However, these effects were reversed by CADD522. These findings indicate that Runx2 could potentially serve as a therapeutic intervention for spinal cord injury (SCI). Furthermore, our findings suggest that the Nuclear-matrix-targeting signal (NMTS) of Runx2 is associated with its effect. In summary, the study’s results propose that targeting Runx2 may be a promising treatment approach for reactive astrocytes and astroglial scar in the recovery of SCI. Graphical Abstract: (Figure presented.) |
资助项目 | Natural Science Foundation of Ningbo[2021J032,2022J044];Wenzhou Science and Technology Innovation Project[ZY2021024,ZY2020026];Natural Science Foundation of Zhejiang Province[LY23H060004]; |
出版者 | SPRINGER |
ISSN | 0893-7648 |
EISSN | 1559-1182 |
DOI | 10.1007/s12035-024-04212-6 |
页数 | 10 |
WOS类目 | Neurosciences |
WOS研究方向 | Neurosciences & Neurology |
WOS记录号 | WOS:001235770300001 |
收录类别 | SCOPUS ; SCIE ; PUBMED |
URL | 查看原文 |
PubMed ID | 38789894 |
SCOPUSEID | 2-s2.0-85194087253 |
通讯作者地址 | [Chen, Daqing]Department of Emergency,The Second Affiliated Hospital and Yuying Children’s Hospital,Wenzhou Medical University,Zhejiang,Wenzhou,325027,China |
Scopus学科分类 | Neuroscience (miscellaneous);Neurology;Cellular and Molecular Neuroscience |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.wmu.edu.cn/handle/3ETUA0LF/213437 |
专题 | 附属第二医院 药学院(分析测试中心) 其他_温州市第三临床学院(温州市人民医院) |
通讯作者 | Chen, Daqing |
作者单位 | 1.Department of Emergency,The Second Affiliated Hospital and Yuying Children’s Hospital,Wenzhou Medical University,Zhejiang,Wenzhou,325027,China; 2.School of Pharmaceutical Sciences,Wenzhou Medical University,Zhejiang,Wenzhou,325000,China; 3.School of Pharmaceutical Sciences,Cixi Biomedical Research Institute,Wenzhou Medical University,Zhejiang,Wenzhou,325035,China; 4.Department of Ultrasound,Dongtou District People’s Hospital,Zhejiang,Wenzhou,325700,China; 5.The Wenzhou Third Clinical Institute Affiliated To Wenzhou Medical University,Wenzhou Medical University,Zhejiang,Wenzhou,325000,China |
第一作者单位 | 附属第二医院 |
通讯作者单位 | 附属第二医院 |
第一作者的第一单位 | 附属第二医院 |
推荐引用方式 GB/T 7714 | Lu, Leilei,Ye, Jiazong,Yi, Dafa,et al. Runx2 Suppresses Astrocyte Activation and Astroglial Scar Formation After Spinal Cord Injury in Mice[J]. Molecular Neurobiology;,2024. |
APA | Lu, Leilei., Ye, Jiazong., Yi, Dafa., Qi, Tengfei., Luo, Tong., ... & Chen, Daqing. (2024). Runx2 Suppresses Astrocyte Activation and Astroglial Scar Formation After Spinal Cord Injury in Mice. Molecular Neurobiology;. |
MLA | Lu, Leilei,et al."Runx2 Suppresses Astrocyte Activation and Astroglial Scar Formation After Spinal Cord Injury in Mice".Molecular Neurobiology; (2024). |
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