Runx2 Suppresses Astrocyte Activation and Astroglial Scar Formation After Spinal Cord Injury in Mice

doi:10.1007/s12035-024-04212-6

科研成果详情

题名	Runx2 Suppresses Astrocyte Activation and Astroglial Scar Formation After Spinal Cord Injury in Mice
作者	Lu, Leilei1; Ye, Jiazong 4; Yi, Dafa3; Qi, Tengfei3; Luo, Tong 1; Wu, Silei5; Yang, Liangliang2; Li, Lei2; Zhang, Hongyu2; Chen, Daqing1
发表日期	2024
发表期刊	Molecular Neurobiology; 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Astrocytes Astroglial scar Nuclear-matrix-targeting signal Runx2 Spinal cord injury
其他关键词	APOPTOSIS
摘要	After spinal cord injury, astrocytes undergo a reactive process and form an astroglial scar, which impedes the regeneration of axons. The role of Runx2 in promoting the transformation of astrocytes in the central nervous system is well-established. However, it remains unclear whether Runx2 also plays a role in the development of astroglial scar, and the precise underlying mechanism has yet to be identified. Recently, our study using cell culture and animal models has demonstrated that Runx2 actually suppresses astrocyte activation and the formation of astroglial scar following injury. The initial results demonstrated an increase in the expression of Runx2 in astrocytes following in vivo injury. Subsequently, the overexpression of Runx2 resulted in the inhibition of astrocyte activation, reduction in the total area of astroglial scar, and restoration of neural function after 14 days of injury. However, these effects were reversed by CADD522. These findings indicate that Runx2 could potentially serve as a therapeutic intervention for spinal cord injury (SCI). Furthermore, our findings suggest that the Nuclear-matrix-targeting signal (NMTS) of Runx2 is associated with its effect. In summary, the study’s results propose that targeting Runx2 may be a promising treatment approach for reactive astrocytes and astroglial scar in the recovery of SCI. Graphical Abstract: (Figure presented.)
资助项目	Natural Science Foundation of Ningbo[2021J032,2022J044];Wenzhou Science and Technology Innovation Project[ZY2021024,ZY2020026];Natural Science Foundation of Zhejiang Province[LY23H060004];
出版者	SPRINGER
ISSN	0893-7648
EISSN	1559-1182
DOI	10.1007/s12035-024-04212-6
页数	10
WOS类目	Neurosciences
WOS研究方向	Neurosciences & Neurology
WOS记录号	WOS:001235770300001
收录类别	SCOPUS ; SCIE ; PUBMED
URL	查看原文
PubMed ID	38789894
SCOPUSEID	2-s2.0-85194087253
通讯作者地址	[Chen, Daqing]Department of Emergency,The Second Affiliated Hospital and Yuying Children’s Hospital,Wenzhou Medical University,Zhejiang,Wenzhou,325027,China
Scopus学科分类	Neuroscience (miscellaneous);Neurology;Cellular and Molecular Neuroscience
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/213437
专题	附属第二医院药学院（分析测试中心）其他_温州市第三临床学院（温州市人民医院）
通讯作者	Chen, Daqing
作者单位	1.Department of Emergency,The Second Affiliated Hospital and Yuying Children’s Hospital,Wenzhou Medical University,Zhejiang,Wenzhou,325027,China; 2.School of Pharmaceutical Sciences,Wenzhou Medical University,Zhejiang,Wenzhou,325000,China; 3.School of Pharmaceutical Sciences,Cixi Biomedical Research Institute,Wenzhou Medical University,Zhejiang,Wenzhou,325035,China; 4.Department of Ultrasound,Dongtou District People’s Hospital,Zhejiang,Wenzhou,325700,China; 5.The Wenzhou Third Clinical Institute Affiliated To Wenzhou Medical University,Wenzhou Medical University,Zhejiang,Wenzhou,325000,China
第一作者单位	附属第二医院
通讯作者单位	附属第二医院
第一作者的第一单位	附属第二医院
推荐引用方式 GB/T 7714	Lu, Leilei,Ye, Jiazong,Yi, Dafa,et al. Runx2 Suppresses Astrocyte Activation and Astroglial Scar Formation After Spinal Cord Injury in Mice[J]. Molecular Neurobiology;,2024.
APA	Lu, Leilei., Ye, Jiazong., Yi, Dafa., Qi, Tengfei., Luo, Tong., ... & Chen, Daqing. (2024). Runx2 Suppresses Astrocyte Activation and Astroglial Scar Formation After Spinal Cord Injury in Mice. Molecular Neurobiology;.
MLA	Lu, Leilei,et al."Runx2 Suppresses Astrocyte Activation and Astroglial Scar Formation After Spinal Cord Injury in Mice".Molecular Neurobiology; (2024).