Detection of elevated levels of PINK1 in plasma from patients with idiopathic Parkinson’s disease

doi:10.3389/fnagi.2024.1369014

科研成果详情

题名	Detection of elevated levels of PINK1 in plasma from patients with idiopathic Parkinson’s disease
作者	Hong, Xianchai1; Zheng, Yi 2; Hou, Jialong2; Jiang, Tao2; Lu, Yao2,3; Wang, Wenwen 4; Zhou, Shuoting2; Ye, Qianqian 2; Xie, Chenglong 2,5,6,7; Li, Jia 2
发表日期	2024
发表期刊	Frontiers in Aging Neuroscience; 影响因子和分区
语种	英语
原始文献类型	Article
关键词	biomarkers mitophagy Parkinson’s disease PINK1 α-synuclein oligomer
其他关键词	ALPHA-SYNUCLEIN OLIGOMERS ; POTENTIAL BIOMARKER ; MITOPHAGY ; DEMENTIA
摘要	Backgrounds: Numerous lines of evidence support the intricate interplay between Parkinson’s disease (PD) and the PINK1-dependent mitophagy process. This study aimed to evaluate differences in plasma PINK1 levels among idiopathic PD, PD syndromes (PDs), and healthy controls. Methods: A total of 354 participants were included, consisting of 197 PD patients, 50 PDs patients, and 107 healthy controls were divided into two cohorts, namely the modeling cohort (cohort 1) and the validated cohort (cohort 2). An enzyme-linked immunosorbent assay (ELISA)-based analysis was performed on PINK1 and α-synuclein oligomer (Asy-no). The utilization of the area under the curve (AUC) within the receiver-operating characteristic (ROC) curves served as a robust and comprehensive approach to evaluate and quantify the predictive efficacy of plasma biomarkers alone, as well as combined models, in distinguishing PD patients from controls. Results: PINK1 and Asy-no were elevated in the plasma of PD and PDs patients compared to healthy controls. The AUCs of PINK1 (0.771) and Asy-no (0.787) were supposed to be potentially eligible plasma biomarkers differentiating PD from controls but could not differentiate PD from PDs. Notably, the PINK + Asy-no + Clinical RBD model showed the highest performance in the modeling cohort and was comparable with the PINK1 + Clinical RBD in the validation cohort. Moreover, there is no significant correlation between PINK1 and UPDRS, MMSE, HAMD, HAMA, RBDQ-HK, and ADL scores. Conclusion: These findings suggest that elevated PINK1 in plasma holds the potential to serve as a non-invasive tool for distinguishing PD patients from controls. Moreover, the outcomes of our investigation lend support to the plausibility of implementing a feasible blood test in future clinical translation.
资助项目	Natural Science Foundation of Zhejiang Province[LZ23H090001,Y19H090059,LQ23H090007];National Science Foundation of China[81600977,82271469];Wenzhou City Committee of Science and Technology[Y20220164];
出版者	Frontiers Media SA
ISSN	1663-4365
卷号	16
DOI	10.3389/fnagi.2024.1369014
页数	12
WOS类目	Geriatrics & Gerontology ; Neurosciences
WOS研究方向	Geriatrics & Gerontology ; Neurosciences & Neurology
WOS记录号	WOS:001258504600001
收录类别	SCOPUS ; PUBMED ; SCIE
URL	查看原文
PubMed ID	38711597
SCOPUSEID	2-s2.0-85192100286
通讯作者地址	[Xie, Chenglong]Department of Neurology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China ; [Li, Jia]Department of Neurology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Aging;Cognitive Neuroscience
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/212724
专题	附属第一医院温州医科大学第二临床医学院，附属第二医院、育英儿童医院第一临床医学院（信息与工程学院）、附属第一医院_内科学_神经内科
通讯作者	Xie, Chenglong; Li, Jia
作者单位	1.Department of Neurology Nursing Unit 362 Ward,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 2.Department of Neurology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 3.Department of Neurology,Yuhuan City People's Hospital,Taizhou,China; 4.The Center of Traditional Chinese Medicine,The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,Wenzhou,China; 5.Key Laboratory of Alzheimer's Disease of Zhejiang Province,Wenzhou City,China; 6.Institute of Aging,Wenzhou Medical University,Zhejiang,Wenzhou,China; 7.Oujiang Laboratory,Zhejiang,Wenzhou,China
第一作者单位	附属第一医院
通讯作者单位	第一临床医学院（信息与工程学院）、附属第一医院_内科学_神经内科
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Hong, Xianchai,Zheng, Yi,Hou, Jialong,et al. Detection of elevated levels of PINK1 in plasma from patients with idiopathic Parkinson’s disease[J]. Frontiers in Aging Neuroscience;,2024,16.
APA	Hong, Xianchai., Zheng, Yi., Hou, Jialong., Jiang, Tao., Lu, Yao., ... & Li, Jia. (2024). Detection of elevated levels of PINK1 in plasma from patients with idiopathic Parkinson’s disease. Frontiers in Aging Neuroscience;, 16.
MLA	Hong, Xianchai,et al."Detection of elevated levels of PINK1 in plasma from patients with idiopathic Parkinson’s disease".Frontiers in Aging Neuroscience; 16(2024).