Unveiling intratumoral microbiota: an emerging force for colorectal cancer diagnosis and therapy

doi:10.1016/j.phrs.2024.107185

科研成果详情

题名	Unveiling intratumoral microbiota: an emerging force for colorectal cancer diagnosis and therapy
作者	Zhang, Jinjing 1; Wang, Penghui1; Wang, Jiafeng 2; Wei, Xiaojie1; Wang, Mengchuan 1
发表日期	2024-04-12
发表期刊	Pharmacological research 影响因子和分区
语种	英语
原始文献类型	Journal Article ; Review
关键词	Cancer treatment Gastrointestinal cancer Gut microbiota Immunotherapy Microbial biomarker Tumor microbiome
其他关键词	ENTEROTOXIGENIC BACTEROIDES-FRAGILIS ; MECHANISMS ; INHIBITION ; APOPTOSIS ; BACTERIA ; DELIVERY ; BARRIER ; CELLS ; DNA
摘要	Microbes, including bacteria, viruses, fungi, and other eukaryotic organisms, are commonly present in multiple organs of the human body and contribute significantly to both physiological and pathological processes. Nowadays, the development of sequencing technology has revealed the presence and composition of the intratumoral microbiota, which includes Fusobacterium, Bifidobacteria, and Bacteroides, and has shed light on the significant involvement in the progression of colorectal cancer (CRC). Here, we summarized the current understanding of the intratumoral microbiota in CRC and outline the potential translational and clinical applications in the diagnosis, prevention, and treatment of CRC. We focused on reviewing the development of microbial therapies targeting the intratumoral microbiota to improve the efficacy and safety of chemotherapy and immunotherapy for CRC and to identify biomarkers for the diagnosis and prognosis of CRC. Finally, we emphasized the obstacles and potential solutions to translating the knowledge of the intratumoral microbiota into clinical practice.
资助项目	Project of NINGBO Leading Medical & Health Discipline [2022-X22]
出版者	Academic Press
ISSN	1043-6618
EISSN	1096-1186
卷号	203
DOI	10.1016/j.phrs.2024.107185
页数	11
WOS类目	Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
WOS记录号	WOS:001273175300001
收录类别	PUBMED ; SCIE ; SCOPUS
URL	查看原文
PubMed ID	38615875
SCOPUSEID	2-s2.0-85190112651
通讯作者地址	[Wei, Xiaojie]Affiliated Cixi Hospital,Wenzhou Medical University,Zhejiang,China
Scopus学科分类	Pharmacology
TOP期刊	TOP期刊
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/211130
专题	其他_附属慈溪医院（慈溪市人民医院）
通讯作者	Wei, Xiaojie; Wang, Mengchuan
作者单位	1.Affiliated Cixi Hospital,Wenzhou Medical University,Zhejiang,China; 2.Affiliated Hangzhou First People's Hospital,Zhejiang University School of Medicine,Zhejiang,China
第一作者单位	附属慈溪医院（慈溪市人民医院）
通讯作者单位	附属慈溪医院（慈溪市人民医院）
第一作者的第一单位	附属慈溪医院（慈溪市人民医院）
推荐引用方式 GB/T 7714	Zhang, Jinjing,Wang, Penghui,Wang, Jiafeng,et al. Unveiling intratumoral microbiota: an emerging force for colorectal cancer diagnosis and therapy[J]. Pharmacological research,2024,203.
APA	Zhang, Jinjing, Wang, Penghui, Wang, Jiafeng, Wei, Xiaojie, & Wang, Mengchuan. (2024). Unveiling intratumoral microbiota: an emerging force for colorectal cancer diagnosis and therapy. Pharmacological research, 203.
MLA	Zhang, Jinjing,et al."Unveiling intratumoral microbiota: an emerging force for colorectal cancer diagnosis and therapy".Pharmacological research 203(2024).