Exploring Mechanical Forces Shaping Self-Organization and Morphogenesis During Early Embryo Development

doi:10.1146/annurev-cellbio-120123-105748

科研成果详情

题名	Exploring Mechanical Forces Shaping Self-Organization and Morphogenesis During Early Embryo Development
作者	Hong Huang 1; Shaorong Gao 2; Min Bao 1
发表日期	2024-04-12
发表期刊	Annual Review of Cell and Developmental Biology 影响因子和分区
语种	英语
原始文献类型	Journal Article ; Review
关键词	embryo development mechanobiology mechanotransduction cytoskeleton mechanical force
其他关键词	INNER CELL MASS ; PRIMITIVE ENDODERM ; MOUSE EMBRYO ; LINEAGE SEGREGATION ; APICAL DOMAIN ; FATE DECISION ; C-ELEGANS ; POLARITY ; ADHESION ; TROPHECTODERM
摘要	Embryonic development is a dynamic process orchestrated by a delicate interplay of biochemical and biophysical factors. While the role of genetics and biochemistry in embryogenesis has been extensively studied, recent research has highlighted the significance of mechanical regulation in shaping and guiding this intricate process. Here, we provide an overview of the current understanding of the mechanical regulation of embryo development. We explore how mechanical forces generated by cells and tissues play a crucial role in driving the development of different stages. We examine key morphogenetic processes such as compaction, blastocyst formation, implantation, and egg cylinder formation, and discuss the mechanical mechanisms and cues involved. By synthesizing the current body of literature, we highlight the emerging concepts and open questions in the field of mechanical regulation. We aim to provide an overview of the field, inspiring future investigations and fostering a deeper understanding of the mechanical aspects of embryo development.
资助项目	Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision, and Brain Health) [OJQD2022015]; Ministry of Science and Technology of China [2021YFC2700300, 2022YFC2702200]; National Natural Science Foundation of China [82301873, 31721003]
出版者	ANNUAL REVIEWS
ISSN	1081-0706
EISSN	1530-8995
卷号	40 期号:1 页码:75-96
DOI	10.1146/annurev-cellbio-120123-105748
页数	22
WOS类目	Cell Biology ; Developmental Biology
WOS研究方向	Cell Biology ; Developmental Biology
WOS记录号	WOS:001333188800004
收录类别	PUBMED ; SCIE ; SCOPUS
URL	查看原文
PubMed ID	38608312
SCOPUSEID	2-s2.0-85205604344
通讯作者地址	[Huang, Hong]Wenzhou Med Univ, Oujiang Lab, Zhejiang Lab Regenerat Med Vis & Brain Hlth, Affiliated Hosp 1, Wenzhou, Peoples R China.
Scopus学科分类	Developmental Biology;Cell Biology
SCOPUS_ID	SCOPUS_ID:85205604344
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/211118
专题	附属第一医院其他_瓯江实验室
作者单位	1.1Oujiang Laboratory, Zhejiang Lab for Regenerative Medicine, Vision, and Brain Health, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China; email: baomin@ojlab.ac.cn.; 2.2Clinical and Translational Research Center of Shanghai First Maternity and Infant Hospital, Frontier Science Center for Stem Cell Research, School of Life Sciences and Technology, Tongji University, Shanghai, China; email: gaoshaorong@tongji.edu.cn.
第一作者单位	附属第一医院; 瓯江实验室
通讯作者单位	附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Hong Huang,Shaorong Gao,Min Bao. Exploring Mechanical Forces Shaping Self-Organization and Morphogenesis During Early Embryo Development[J]. Annual Review of Cell and Developmental Biology,2024,40(1):75-96.
APA	Hong Huang, Shaorong Gao, & Min Bao. (2024). Exploring Mechanical Forces Shaping Self-Organization and Morphogenesis During Early Embryo Development. Annual Review of Cell and Developmental Biology, 40(1), 75-96.
MLA	Hong Huang,et al."Exploring Mechanical Forces Shaping Self-Organization and Morphogenesis During Early Embryo Development".Annual Review of Cell and Developmental Biology 40.1(2024):75-96.