Palmatine Alleviates Particulate Matter-Induced Acute Lung Injury by Inhibiting Pyroptosis via Activating the Nrf2-Related Pathway

doi:10.1007/s10753-024-02009-2

科研成果详情

题名	Palmatine Alleviates Particulate Matter-Induced Acute Lung Injury by Inhibiting Pyroptosis via Activating the Nrf2-Related Pathway
作者	Zuo, Hao1,2; Zhou, Wanting1,2; Chen, Yijing 1,2; Zhou, Binqian1,2; Wang, Zhengkai1,2,3; Huang, Shuai 1,2; Alinejad, Tahereh 4; Chen, Chengshui1,2,3
发表日期	2024-04-10
发表期刊	INFLAMMATION 影响因子和分区
语种	英语
原始文献类型	Article ; Early Access
关键词	Palmatine particulate matter a cute lung injury pyroptosis Nrf2
摘要	Particulate matter (PM) induces and enhances oxidative stress and inflammation, leading to a variety of respiratory diseases, including acute lung injury. Exploring new treatments for PM-induced lung injury has long been of interest to researchers. Palmatine (PAL) is a natural extract derived from plants that has been reported in many studies to alleviate inflammatory diseases. Our study was designed to explore whether PAL can alleviate acute lung injury caused by PM. The acute lung injury model was established by instilling PM (4 mg/kg) into the airway of mice, and PAL (50 mg/kg and 100 m/kg) was administrated orally as the treatment groups. The effect and mechanism of PAL treatment were examined by immunofluorescence, immunohistochemistry, Western Blotting, ELISA, and other experiments. The results showed that oral administration of PAL (50 mg/kg and 100 m/kg) could significantly alleviate lung inflammation and acute lung injury caused by PM. In terms of mechanism, we found that PAL (50 mg/kg) exerts anti-inflammatory and anti-damage effects mainly by enhancing the activation of the Nrf2-related antioxidant pathway and inhibiting the activation of the NLRP3-related pyroptosis pathway in mice. These mechanisms have also been verified in our cell experiments. Further cell experiments showed that PAL may reduce intracellular reactive oxygen species (ROS) by activating Nrf2-related pathways, thereby inhibiting the activation of NLRP3-related pyroptosis pathway induced by PM in Beas-2B cell. Our study suggests that PAL can be a new option for PM-induced acute lung injury.
资助项目	Key Laboratory of Interventional Pulmonology of Zhejiang Province
出版者	SPRINGER/PLENUM PUBLISHERS
ISSN	0360-3997
EISSN	1573-2576
DOI	10.1007/s10753-024-02009-2
页数	13
WOS类目	Cell Biology ; Immunology
WOS研究方向	Cell Biology ; Immunology
WOS记录号	WOS:001200407100001
收录类别	SCIE ; PUBMED ; SCOPUS
在线发表日期	2024-04
URL	查看原文
PubMed ID	38598115
SCOPUSEID	2-s2.0-85189913936
通讯作者地址	[Chen, Chengshui]Key Laboratory of Interventional Pulmonology of Zhejiang Province,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325015,China
Scopus学科分类	Immunology and Allergy;Immunology
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/211012
专题	附属第一医院其他_温州医科大学附属衢州医院其他_瓯江实验室
通讯作者	Chen, Chengshui
作者单位	1.Key Laboratory of Interventional Pulmonology of Zhejiang Province,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325015,China; 2.Department of Pulmonary and Critical Care Medicine,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 3.Department of Pulmonary and Critical Care Medicine,the,Quzhou Affiliated Hospital of Wenzhou Medical University,Quzhou People’s Hospital,Quzhou,324000,China; 4.Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine,Institute of Cell Growth Factor,and Brain Health),Wenzhou Medical University,VisionWenzhou,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Zuo, Hao,Zhou, Wanting,Chen, Yijing,et al. Palmatine Alleviates Particulate Matter-Induced Acute Lung Injury by Inhibiting Pyroptosis via Activating the Nrf2-Related Pathway[J]. INFLAMMATION,2024.
APA	Zuo, Hao., Zhou, Wanting., Chen, Yijing., Zhou, Binqian., Wang, Zhengkai., ... & Chen, Chengshui. (2024). Palmatine Alleviates Particulate Matter-Induced Acute Lung Injury by Inhibiting Pyroptosis via Activating the Nrf2-Related Pathway. INFLAMMATION.
MLA	Zuo, Hao,et al."Palmatine Alleviates Particulate Matter-Induced Acute Lung Injury by Inhibiting Pyroptosis via Activating the Nrf2-Related Pathway".INFLAMMATION (2024).