题名 | Palmatine Alleviates Particulate Matter-Induced Acute Lung Injury by Inhibiting Pyroptosis via Activating the Nrf2-Related Pathway |
作者 | |
发表日期 | 2024-04-10 |
发表期刊 | INFLAMMATION 影响因子和分区 |
语种 | 英语 |
原始文献类型 | Article ; Early Access |
关键词 | Palmatine particulate matter a cute lung injury pyroptosis Nrf2 |
摘要 | Particulate matter (PM) induces and enhances oxidative stress and inflammation, leading to a variety of respiratory diseases, including acute lung injury. Exploring new treatments for PM-induced lung injury has long been of interest to researchers. Palmatine (PAL) is a natural extract derived from plants that has been reported in many studies to alleviate inflammatory diseases. Our study was designed to explore whether PAL can alleviate acute lung injury caused by PM. The acute lung injury model was established by instilling PM (4 mg/kg) into the airway of mice, and PAL (50 mg/kg and 100 m/kg) was administrated orally as the treatment groups. The effect and mechanism of PAL treatment were examined by immunofluorescence, immunohistochemistry, Western Blotting, ELISA, and other experiments. The results showed that oral administration of PAL (50 mg/kg and 100 m/kg) could significantly alleviate lung inflammation and acute lung injury caused by PM. In terms of mechanism, we found that PAL (50 mg/kg) exerts anti-inflammatory and anti-damage effects mainly by enhancing the activation of the Nrf2-related antioxidant pathway and inhibiting the activation of the NLRP3-related pyroptosis pathway in mice. These mechanisms have also been verified in our cell experiments. Further cell experiments showed that PAL may reduce intracellular reactive oxygen species (ROS) by activating Nrf2-related pathways, thereby inhibiting the activation of NLRP3-related pyroptosis pathway induced by PM in Beas-2B cell. Our study suggests that PAL can be a new option for PM-induced acute lung injury. |
资助项目 | Key Laboratory of Interventional Pulmonology of Zhejiang Province |
出版者 | SPRINGER/PLENUM PUBLISHERS |
ISSN | 0360-3997 |
EISSN | 1573-2576 |
DOI | 10.1007/s10753-024-02009-2 |
页数 | 13 |
WOS类目 | Cell Biology ; Immunology |
WOS研究方向 | Cell Biology ; Immunology |
WOS记录号 | WOS:001200407100001 |
收录类别 | SCIE ; PUBMED ; SCOPUS |
在线发表日期 | 2024-04 |
URL | 查看原文 |
PubMed ID | 38598115 |
SCOPUSEID | 2-s2.0-85189913936 |
通讯作者地址 | [Chen, Chengshui]Key Laboratory of Interventional Pulmonology of Zhejiang Province,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325015,China |
Scopus学科分类 | Immunology and Allergy;Immunology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.wmu.edu.cn/handle/3ETUA0LF/211012 |
专题 | 附属第一医院 其他_温州医科大学附属衢州医院 其他_瓯江实验室 |
通讯作者 | Chen, Chengshui |
作者单位 | 1.Key Laboratory of Interventional Pulmonology of Zhejiang Province,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325015,China; 2.Department of Pulmonary and Critical Care Medicine,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 3.Department of Pulmonary and Critical Care Medicine,the,Quzhou Affiliated Hospital of Wenzhou Medical University,Quzhou People’s Hospital,Quzhou,324000,China; 4.Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine,Institute of Cell Growth Factor,and Brain Health),Wenzhou Medical University,VisionWenzhou,China |
第一作者单位 | 附属第一医院; 第一临床医学院(信息与工程学院)、附属第一医院 |
通讯作者单位 | 附属第一医院; 第一临床医学院(信息与工程学院)、附属第一医院 |
第一作者的第一单位 | 附属第一医院 |
推荐引用方式 GB/T 7714 | Zuo, Hao,Zhou, Wanting,Chen, Yijing,et al. Palmatine Alleviates Particulate Matter-Induced Acute Lung Injury by Inhibiting Pyroptosis via Activating the Nrf2-Related Pathway[J]. INFLAMMATION,2024. |
APA | Zuo, Hao., Zhou, Wanting., Chen, Yijing., Zhou, Binqian., Wang, Zhengkai., ... & Chen, Chengshui. (2024). Palmatine Alleviates Particulate Matter-Induced Acute Lung Injury by Inhibiting Pyroptosis via Activating the Nrf2-Related Pathway. INFLAMMATION. |
MLA | Zuo, Hao,et al."Palmatine Alleviates Particulate Matter-Induced Acute Lung Injury by Inhibiting Pyroptosis via Activating the Nrf2-Related Pathway".INFLAMMATION (2024). |
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