B族链球菌定植产妇的产程管理与围生结局的研究

doi:10.11969/j.issn.1673-548X.2024.01.027

科研成果详情

题名	B族链球菌定植产妇的产程管理与围生结局的研究
其他题名	Study of labor Process Management and Perinatal Outcome in Pregnant Women Colonized with Group B Streptococcus
作者	陈璐璐; 王繁
发表日期	2024-01-15
发表期刊	医学研究杂志影响因子和分区
语种	中文
原始文献类型	学术期刊
关键词	B族链球菌产程管理胎膜破裂持续时间母婴感染
其他关键词	Group B streptococcus ; Labor process management ; Duration of rupture of membranes ; Maternal and infant infection
摘要	目的研究足月B族链球菌(group B streptococcus, GBS)定植产妇的产程管理与围生结局。方法收集2020年10月～2021年11月在温州医科大学附属第二医院、育英儿童医院产科住院的GBS筛查阳性的足月产妇355例(GBS阳性组)和同期GBS筛查阴性的足月产妇355例(GBS阴性组)的临床资料，比较产程特征、胎膜破裂持续时间及围生结局。结果与GBS阴性组比较，GBS阳性组产时发热、产后发热、住院时间、组织学绒毛膜羊膜炎、新生儿转科及新生儿败血症发生率均升高(P<0.05)。两者在产程发动方式、分娩方式、胎膜早破、临床绒毛膜羊膜炎、胎膜破裂持续时间、第一产程、活跃期、第二产程、产后出血、会阴损伤、新生儿出生体重、新生儿性别、胎儿宫内窘迫、新生儿黄疸方面比较，差异无统计学意义(P>0.05)。GBS阳性组中，根据不同胎膜破裂持续时间分为<12h组、≥12且<24h组和≥24h组。<12h组作为对照组。与对照组比较，≥12且<24h组第一产程、活跃期、第二产程、住院时间均显著长于对照组；胎膜早破及产钳助娩率高于对照组(P<0.05);≥24h组第一产程、第二产程、住院时间长于对照组，胎膜早破、产时发热、产后发热、组织学绒毛膜羊膜炎、剖宫产率均高于对照组(P<0.05)。GBS阳性组中，新生儿败血症与新生儿无败血症在产程发动方式、分娩方式、胎膜破裂方式、组织学绒毛膜羊膜炎、胎膜破裂时间及产程方面比较，差异无统计学意义(P>0.05)。结论 GBS定植不影响产程进展，但增加母婴感染风险。GBS定植的足月产妇在胎膜破裂后24h内分娩，可缩短产程，减少分娩并发症，有利于改善不良围生结局。
其他摘要	Objective To study the labor process management and perinatal outcome in full-term pregnant women colonized with group B streptococcus.Methods The clinical data of 355 full-term pregnant women with positive GBS screening(the positive GBS group)and 355 full-term pregnant women with negative GBS screening(the negative GBS group)from October 2020 to November 2021,in the department of obstetrics and gynecology of the Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical Uni-versity were collected.The labor characteristics,duration of rupture of membranes and perinatal outcome were compared between the two groups.Results In the positive GBS group,the incidences of intrapartum fever,postpartum fever,hospital stays,histological chorioam-nionitis,neonatal admission to neonatal intensive care unit(NICU),and neonatal sepsis were higher than those in the negative GBS group(P＜0.05).There was no significant difference between the two groups with mode of initiation of labor,mode of delivery,premature rup-ture of membrane,clinical chorioamnionitis,duration of rupture of membranes,the first stage of labor,the active stage,the second stage of labor,birth weight of newborn,gender of newborn,fetal distress,and neonatal jaundice(P＞0.05).According to the difference of in-terval between rupture of the fetal membranes,the positive GBS group was divided into three groups:＜12 hours group,≥12 and＜24 hours group,and ≥ 24 hours group.The＜12 hours group was selected as the control group.In the ≥ 12 and＜24 hours group,the first stage of labor,active stage,second stage of labor,and hospital stay were longer than those in the control group.The incidence of prema-ture rupture of membranes of term and forceps delivery was higher than that in the control group(P＜0.05).In the ≥ 24 hours group,the first stage of labor,second stage of labor,and hospital stay were longer than those in the control group.The incidence of premature rup-ture of membranes of term,intrapartum fever,postpartum fever,histological chorioamnionitis,and cesarean section was higher than that in the control group(P＜0.05).In the GBS positive group,there was no significant difference between neonatal sepsis and neonatal no-sepsis of mode of initiation of labor,mode of delivery,type of rupture of membranes,histological chorioamnionitis,duration of rupture of membranes,and duration of labor(P＞0.05).Conclusion The labor process is not affected by GBS.However,GBS increases the risk of maternal and infant infection.The full-term women colonized with group B streptococcus delivery within 24 hours after rupture of membranes,which can shorten labor,reduce labor complications,and improve adverse perinatal outcomes.
资助项目	浙江省温州市科技局基础性科研项目(Y2020504);
ISSN	1673-548X
卷号	53 期号:01 页码:136-141
DOI	10.11969/j.issn.1673-548X.2024.01.027
页数	6
收录类别	CNKI ; 万方 ; 维普
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引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/210542
专题	第二临床医学院、附属第二医院、育英儿童医院附属第二医院附属第二医院_产科
通讯作者	王繁
作者单位	温州医科大学附属第二医院、育英儿童医院产科
第一作者单位	附属第二医院; 第二临床医学院，附属第二医院、育英儿童医院; 产科
第一作者的第一单位	附属第二医院
推荐引用方式 GB/T 7714	陈璐璐,王繁. B族链球菌定植产妇的产程管理与围生结局的研究[J]. 医学研究杂志,2024,53(01):136-141.
APA	陈璐璐, & 王繁. (2024). B族链球菌定植产妇的产程管理与围生结局的研究. 医学研究杂志, 53(01), 136-141.
MLA	陈璐璐,et al."B族链球菌定植产妇的产程管理与围生结局的研究".医学研究杂志 53.01(2024):136-141.