Serum Iron Levels, Dietary Iron Intake, and Supplement Use in Relation to Metabolic Syndrome in Adolescents: A Cross-Sectional Study

doi:10.1007/s12011-024-04152-1

科研成果详情

题名	Serum Iron Levels, Dietary Iron Intake, and Supplement Use in Relation to Metabolic Syndrome in Adolescents: A Cross-Sectional Study
作者	Wang, Meng 1,2,3; Chen, Zhiyuan 1,2,3; Zhang, Yuanfeng 4
发表日期	2024-03-22
发表期刊	Biological trace element research 影响因子和分区
语种	英语
原始文献类型	Journal Article
关键词	Dietary iron Iron supplements Metabolic syndrome NHANES Serum iron
摘要	The objective of this study was to investigate the potential associations between serum iron levels, dietary iron intake, and iron supplementation, and the prevalence of metabolic syndrome (MetS) in adolescents A cross-sectional analysis was conducted, utilizing data from adolescents participating in the 2003-2018 cycle of the National Health and Nutrition Examination Survey (NHANES). Odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) pertaining to serum iron, dietary iron, and iron supplementation were derived through multivariate logistic regression models. Additionally, a restricted cubic spline (RCS) regression model was applied to explore the nonlinear relationship between dietary iron and serum iron concerning MetS. The study encompassed 4858 American adolescents aged 12 to 19, among whom 413 (8.5%) manifested MetS. The study cohort exhibited an average age of 15.52 years, comprising 2551 males (52.51%) and 2307 females (47.49%). Relative to individuals in the lowest serum iron quartile, those in the highest quartile for serum iron (OR = 0.33, 95% CI 0.21-0.50), the highest quartile for dietary iron (OR = 0.53, 95% CI 0.32-0.89), and those utilizing iron supplements (OR = 0.61, 95% CI 0.37-0.99) evinced a diminished prevalence of MetS, even post adjustment for potential confounding variables. A non-linear relationship was discerned between serum iron and MetS, exhibiting a statistically significant negative correlation when serum iron concentrations exceeded the inflection point (serum iron = 8.66 µmol/L, P for nonlinear < 0.001). This investigation reveals that higher levels of serum iron, increased dietary iron intake, and the use of iron supplements are linked to a lower prevalence of MetS in US adolescents. These findings suggest that dietary modifications could play a role in promoting the health of adolescents.
出版者	Springer
ISSN	0163-4984
EISSN	1559-0720
DOI	10.1007/s12011-024-04152-1
收录类别	PUBMED ; SCOPUS
URL	查看原文
PubMed ID	38517678
SCOPUSEID	2-s2.0-85188527497
通讯作者地址	[Chen, Zhiyuan]Department of Pediatrics,The Third Affiliated Hospital of Shanghai University,Wenzhou,325000,China
Scopus学科分类	Endocrinology, Diabetes and Metabolism;Biochemistry;Clinical Biochemistry;Inorganic Chemistry;Biochemistry (medical)
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/210359
专题	第二临床医学院，附属第二医院、育英儿童医院_儿科学
通讯作者	Chen, Zhiyuan
作者单位	1.Department of Pediatrics,The Third Affiliated Hospital of Shanghai University,Wenzhou,325000,China; 2.Department of Pediatrics,Wenzhou People’s Hospital,Wenzhou,325000,China; 3.Department of Pediatrics,Wenzhou People’s Hospital,Wenzhou Third Clinical Institute Affiliated to Wenzhou Medical University,Zhejiang,Wenzhou,325000,China; 4.Department of Urology,Shantou Central Hospital,Shantou,515000,China
第一作者单位	第二临床医学院，附属第二医院、育英儿童医院_儿科学
推荐引用方式 GB/T 7714	Wang, Meng,Chen, Zhiyuan,Zhang, Yuanfeng. Serum Iron Levels, Dietary Iron Intake, and Supplement Use in Relation to Metabolic Syndrome in Adolescents: A Cross-Sectional Study[J]. Biological trace element research,2024.
APA	Wang, Meng, Chen, Zhiyuan, & Zhang, Yuanfeng. (2024). Serum Iron Levels, Dietary Iron Intake, and Supplement Use in Relation to Metabolic Syndrome in Adolescents: A Cross-Sectional Study. Biological trace element research.
MLA	Wang, Meng,et al."Serum Iron Levels, Dietary Iron Intake, and Supplement Use in Relation to Metabolic Syndrome in Adolescents: A Cross-Sectional Study".Biological trace element research (2024).