Causal association between mTOR-dependent circulating protein levels and central precocious puberty: a Mendelian randomization study

doi:10.3389/fendo.2024.1360043

科研成果详情

题名	Causal association between mTOR-dependent circulating protein levels and central precocious puberty: a Mendelian randomization study
作者	Ying, Yuanxiao 1; Yu, Ze2; Wu, Liping3
发表日期	2024-03-07
发表期刊	Frontiers in endocrinology 影响因子和分区
语种	英语
原始文献类型	Journal Article
关键词	Mendelian randomization causal relationship central precocious puberty eIF4G mTOR
其他关键词	PHOSPHORYLATION ; INSTRUMENTS ; KISSPEPTIN ; DIAGNOSIS ; PATHWAY ; LEPTIN ; RICTOR
摘要	The mechanistic target of rapamycin (mTOR) signaling pathway has a significant effect on central precocious puberty (CPP). However, the causality between mTOR-dependent circulating protein levels and CPP is still unclear. Our aim is to assess the effects of seven mTOR-dependent circulating protein levels on CPP using Mendelian randomization (MR)., Instrumental variables (IVs) for mTOR-dependent circulating protein levels were retrieved from the proteomics-GWAS INTERVAL study and eQTLGen. The summary-level genetic datasets for CPP outcome were obtained from the FinnGen Consortium. Inverse-variance weighted (IVW) was used as the primary method and the pleiotropy, heterogeneity and robustness of the analyses were detected as sensitivity analysis. Positive exposures in the discovery cohort would be revalidated in the validation cohort., {AbstractText=This two-sample MR study revealed a causal association between eIF4G level in plasma and CPP in both discovery cohort (IVW: OR = 0.45, 95% CI = 0.22-0.91, p = 0.026) and validation cohort (IVW: OR = 0.45, 95% CI = 0.24-0.85, p = 0.014).}, There was a causal association between eIF4G level in plasma and CPP. Whether eIF4G can be used for the prevention or treatment of CPP needs to be explored in further studies.
资助项目	National Natural Science Foundation of China [81502106, 81971864]; Zhoushan Medical and Health Science and Technology Project [2021YA08-01]; Science and Technology Department of Zhejiang Province of China [LGF21H160020]
出版者	FRONTIERS MEDIA SA
ISSN	1664-2392
卷号	15
DOI	10.3389/fendo.2024.1360043
页数	8
WOS类目	Endocrinology & Metabolism
WOS研究方向	Endocrinology & Metabolism
WOS记录号	WOS:001187852400001
收录类别	PUBMED ; SCOPUS ; SCIE
URL	查看原文
PubMed ID	3851641
SCOPUSEID	2-s2.0-85188146633
通讯作者地址	[Yu, Ze]Laboratory of Cytobiology & Molecular Biology,Zhoushan Hospital,Wenzhou Medical University,Zhoushan,China ; [Wu, Liping]Science and Education Section,Zhoushan Hospital,Wenzhou Medical University,Zhoushan,China
Scopus学科分类	Endocrinology, Diabetes and Metabolism
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/210356
专题	第二临床医学院，附属第二医院、育英儿童医院_儿科学其他_附属舟山医院（舟山医院）
通讯作者	Yu, Ze; Wu, Liping
作者单位	1.Department of Pediatrics,Zhoushan Hospital,Wenzhou Medical University,Zhoushan,China; 2.Laboratory of Cytobiology & Molecular Biology,Zhoushan Hospital,Wenzhou Medical University,Zhoushan,China; 3.Science and Education Section,Zhoushan Hospital,Wenzhou Medical University,Zhoushan,China
第一作者单位	第二临床医学院，附属第二医院、育英儿童医院_儿科学
通讯作者单位	其他_附属舟山医院（舟山医院）
第一作者的第一单位	第二临床医学院，附属第二医院、育英儿童医院_儿科学
推荐引用方式 GB/T 7714	Ying, Yuanxiao,Yu, Ze,Wu, Liping. Causal association between mTOR-dependent circulating protein levels and central precocious puberty: a Mendelian randomization study[J]. Frontiers in endocrinology,2024,15.
APA	Ying, Yuanxiao, Yu, Ze, & Wu, Liping. (2024). Causal association between mTOR-dependent circulating protein levels and central precocious puberty: a Mendelian randomization study. Frontiers in endocrinology, 15.
MLA	Ying, Yuanxiao,et al."Causal association between mTOR-dependent circulating protein levels and central precocious puberty: a Mendelian randomization study".Frontiers in endocrinology 15(2024).