Preparation of VX765 sodium alginate nanogels and evaluation of their therapeutic effect via local injection on myocardial infarction in rats

doi:10.1186/s40001-024-01765-z

科研成果详情

题名	Preparation of VX765 sodium alginate nanogels and evaluation of their therapeutic effect via local injection on myocardial infarction in rats
作者	Liu, Jianlong; Tian, Qingxin; Zhang, Mingxiao
发表日期	2024-03-12
发表期刊	European Journal of Medical Research 影响因子和分区
语种	英语
原始文献类型	Journal Article
关键词	Caspase-1 inhibitor Myocardial infarction Nanogel Sodium alginate
其他关键词	REPAIR
摘要	Myocardial Infarction (MI) is major cause of heart failure, highlighting the critical need for effective therapeutic strategies to improve cardiac repair. This study investigated the cardioprotective effects of VX765-coated polyethyleneimine (PEI)/sodium alginate (AG) composite nanogels (AG/PEI-VX765 NGs) in a rat model of MI. Additionally, AG-VX765 NGs and PEI-VX765 nanospheres (NPs) were synthesized and tested to compare their efficacy. MI was caused in rats by ligating the left anterior descending branch of the coronary artery, and the rats were grouped and set as Sham, MI, MI + VX765, MI + AG-VX765NGs, MI + PEI-VX765NPs, and MI + AG/PEI-VX765NGs. Results demonstrate that AG/PEI-VX765NGs were non-toxic and exhibited a sustained release of VX765. In vivo, experiments demonstrated that all treatment groups significantly enhanced cardiac function, reduced infarct size, fibrosis, and apoptosis in rats with MI, with the MI + AG/PEI-VX765NGs group exhibiting the most favorable outcomes. Our findings indicate that AG/PEI-VX765NGs represent a promising therapeutic approach for MI treatment.
资助项目	Wenzhou Science and Technology Bureau
出版者	BMC
ISSN	0949-2321
EISSN	2047-783X
卷号	29 期号:1
DOI	10.1186/s40001-024-01765-z
页数	10
WOS类目	Medicine, Research & Experimental
WOS研究方向	Research & Experimental Medicine
WOS记录号	WOS:001184042300007
收录类别	PUBMED ; SCOPUS ; SCIE
URL	查看原文
PubMed ID	3847592
SCOPUSEID	2-s2.0-85187436058
通讯作者地址	[Zhang, Mingxiao]Department of Anesthesiology,The First Affiliated Hospital of Wenzhou Medical University,Shangcai Village, Nanbaixiang, Ouhai District, Zhejiang,Wenzhou,325000,China
Scopus学科分类	Medicine (all)
SCOPUS_ID	SCOPUS_ID:85187436058
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/210265
专题	附属第一医院第一临床医学院（信息与工程学院）、附属第一医院第一临床医学院（信息与工程学院）、附属第一医院_麻醉科
通讯作者	Zhang, Mingxiao
作者单位	Department of Anesthesiology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院; 麻醉科
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院; 麻醉科
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Liu, Jianlong,Tian, Qingxin,Zhang, Mingxiao. Preparation of VX765 sodium alginate nanogels and evaluation of their therapeutic effect via local injection on myocardial infarction in rats[J]. European Journal of Medical Research,2024,29(1).
APA	Liu, Jianlong, Tian, Qingxin, & Zhang, Mingxiao. (2024). Preparation of VX765 sodium alginate nanogels and evaluation of their therapeutic effect via local injection on myocardial infarction in rats. European Journal of Medical Research, 29(1).
MLA	Liu, Jianlong,et al."Preparation of VX765 sodium alginate nanogels and evaluation of their therapeutic effect via local injection on myocardial infarction in rats".European Journal of Medical Research 29.1(2024).