科研成果详情

题名Preparation of VX765 sodium alginate nanogels and evaluation of their therapeutic effect via local injection on myocardial infarction in rats
作者
发表日期2024-03-12
发表期刊European Journal of Medical Research   影响因子和分区
语种英语
原始文献类型Journal Article
关键词Caspase-1 inhibitor Myocardial infarction Nanogel Sodium alginate
其他关键词REPAIR
摘要Myocardial Infarction (MI) is major cause of heart failure, highlighting the critical need for effective therapeutic strategies to improve cardiac repair. This study investigated the cardioprotective effects of VX765-coated polyethyleneimine (PEI)/sodium alginate (AG) composite nanogels (AG/PEI-VX765 NGs) in a rat model of MI. Additionally, AG-VX765 NGs and PEI-VX765 nanospheres (NPs) were synthesized and tested to compare their efficacy. MI was caused in rats by ligating the left anterior descending branch of the coronary artery, and the rats were grouped and set as Sham, MI, MI + VX765, MI + AG-VX765NGs, MI + PEI-VX765NPs, and MI + AG/PEI-VX765NGs. Results demonstrate that AG/PEI-VX765NGs were non-toxic and exhibited a sustained release of VX765. In vivo, experiments demonstrated that all treatment groups significantly enhanced cardiac function, reduced infarct size, fibrosis, and apoptosis in rats with MI, with the MI + AG/PEI-VX765NGs group exhibiting the most favorable outcomes. Our findings indicate that AG/PEI-VX765NGs represent a promising therapeutic approach for MI treatment.
资助项目Wenzhou Science and Technology Bureau
出版者BMC
ISSN0949-2321
EISSN2047-783X
卷号29期号:1
DOI10.1186/s40001-024-01765-z
页数10
WOS类目Medicine, Research & Experimental
WOS研究方向Research & Experimental Medicine
WOS记录号WOS:001184042300007
收录类别PUBMED ; SCOPUS ; SCIE
URL查看原文
PubMed ID3847592
SCOPUSEID2-s2.0-85187436058
通讯作者地址[Zhang, Mingxiao]Department of Anesthesiology,The First Affiliated Hospital of Wenzhou Medical University,Shangcai Village, Nanbaixiang, Ouhai District, Zhejiang,Wenzhou,325000,China
Scopus学科分类Medicine (all)
SCOPUS_IDSCOPUS_ID:85187436058
引用统计
文献类型期刊论文
条目标识符https://kms.wmu.edu.cn/handle/3ETUA0LF/210265
专题附属第一医院
第一临床医学院(信息与工程学院)、附属第一医院
第一临床医学院(信息与工程学院)、附属第一医院_麻醉科
通讯作者Zhang, Mingxiao
作者单位
Department of Anesthesiology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
第一作者单位附属第一医院;  第一临床医学院(信息与工程学院)、附属第一医院;  麻醉科
通讯作者单位附属第一医院;  第一临床医学院(信息与工程学院)、附属第一医院;  麻醉科
第一作者的第一单位附属第一医院
推荐引用方式
GB/T 7714
Liu, Jianlong,Tian, Qingxin,Zhang, Mingxiao. Preparation of VX765 sodium alginate nanogels and evaluation of their therapeutic effect via local injection on myocardial infarction in rats[J]. European Journal of Medical Research,2024,29(1).
APA Liu, Jianlong, Tian, Qingxin, & Zhang, Mingxiao. (2024). Preparation of VX765 sodium alginate nanogels and evaluation of their therapeutic effect via local injection on myocardial infarction in rats. European Journal of Medical Research, 29(1).
MLA Liu, Jianlong,et al."Preparation of VX765 sodium alginate nanogels and evaluation of their therapeutic effect via local injection on myocardial infarction in rats".European Journal of Medical Research 29.1(2024).

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