Multimodal radiomics based on 18F-Prostate-specific membrane antigen-1007 PET/CT and multiparametric MRI for prostate cancer extracapsular extension prediction

doi:10.1093/bjr/tqad038

科研成果详情

题名	Multimodal radiomics based on 18F-Prostate-specific membrane antigen-1007 PET/CT and multiparametric MRI for prostate cancer extracapsular extension prediction
作者	Pan, Kehua1; Yao, Fei1; Hong, Weifeng 2; Xiao, Juan1; Bian, Shuying1; Zhu, Dongqin3; Yuan, Yaping4; Zhang, Yayun3; Zhuang, Yuandi1; Yang, Yunjun3,5
发表日期	2024-02-02
发表期刊	BRITISH JOURNAL OF RADIOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	prostate cancer multimodal imaging radiomics extracapsular extension F-18-PSMA-1007 PET/CT multiparametric magnetic resonance imaging
其他关键词	POSITRON-EMISSION-TOMOGRAPHY ; EXTRAPROSTATIC EXTENSION ; DIAGNOSIS ; RISK
摘要	Objectives: To compare the performance of the multiparametric magnetic resonance imaging (mpMRI) radiomics and F-18-Prostate-specific membrane antigen (PSMA)-1007 PET/CT radiomics model in diagnosing extracapsular extension (EPE) in prostate cancer (PCa), and to evaluate the performance of a multimodal radiomics model combining mpMRI and PET/CT in predicting EPE. Methods: We included 197 patients with PCa who underwent preoperative mpMRI and PET/CT before surgery. mpMRI and PET/CT images were segmented to delineate the regions of interest and extract radiomics features. PET/CT, mpMRI, and multimodal radiomics models were constructed based on maximum correlation, minimum redundancy, and logistic regression analyses. Model performance was evaluated using the area under the receiver operating characteristic curve (AUC) and indices derived from the confusion matrix. Results: AUC values for the mpMRI, PET/CT, and multimodal radiomics models were 0.85 (95% CI, 0.78-0.90), 0.73 (0.64-0.80), and 0.83 (0.75-0.89), respectively, in the training cohort and 0.74 (0.61-0.85), 0.62 (0.48-0.74), and 0.77 (0.64-0.87), respectively, in the testing cohort. The net reclassification improvement demonstrated that the mpMRI radiomics model outperformed the PET/CT one in predicting EPE, with better clinical benefits. The multimodal radiomics model performed better than the single PET/CT radiomics model (P < .05). Conclusion: The mpMRI and( 18)F-PSMA-PET/CT combination enhanced the predictive power of EPE in patients with PCa. The multimodal radiomics model will become a reliable and robust tool to assist urologists and radiologists in making preoperative decisions. Advances in knowledge: This study presents the first application of multimodal radiomics based on PET/CT and MRI for predicting EPE.
资助项目	Wenzhou Major Program of Science and Technology Innovation [ZY2020012]; Key Laboratory of Novel Nuclide Technologies on Precision Diagnosis and Treatment & clinical Transformation of Wenzhou [2023HZSY0012]; Taizhou Science and Technology Project [20ywb156]; Project of Zhejiang Provincial Natural Science Foundation [LQ18H280007]
出版者	BRITISH INST RADIOLOGY
ISSN	0007-1285
EISSN	1748-880X
卷号	97 期号:1154 页码:408-414
DOI	10.1093/bjr/tqad038
页数	7
WOS类目	Radiology, Nuclear Medicine & Medical Imaging
WOS研究方向	Radiology, Nuclear Medicine & Medical Imaging
WOS记录号	WOS:001156453900023
收录类别	SCIE ; PUBMED
URL	查看原文
PubMed ID	38308032
通讯作者地址	[Yang, Yunjun]Wenzhou Med Univ, Affiliated Hosp 1, Dept Nucl Med, Nanbaixiang St, Wenzhou 325000, Peoples R China.
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/209852
专题	第一临床医学院（信息与工程学院）、附属第一医院_影像医学与核医学_放射科第一临床医学院（信息与工程学院）、附属第一医院附属第一医院
通讯作者	Yang, Yunjun
作者单位	1.Wenzhou Med Univ, Affiliated Hosp 1, Dept Radiol, Wenzhou 325000, Peoples R China; 2.Peoples Hosp Yuhuan, Dept Radiol, Taizhou 318000, Peoples R China; 3.Wenzhou Med Univ, Affiliated Hosp 1, Dept Nucl Med, Wenzhou 325000, Peoples R China; 4.Wenzhou Med Univ, Clin Med Coll 1, Wenzhou 325000, Peoples R China; 5.Wenzhou Med Univ, Affiliated Hosp 1, Dept Nucl Med, Nanbaixiang St, Wenzhou 325000, Peoples R China
第一作者单位	第一临床医学院（信息与工程学院）、附属第一医院_影像医学与核医学_放射科
通讯作者单位	附属第一医院
第一作者的第一单位	第一临床医学院（信息与工程学院）、附属第一医院_影像医学与核医学_放射科
推荐引用方式 GB/T 7714	Pan, Kehua,Yao, Fei,Hong, Weifeng,et al. Multimodal radiomics based on 18F-Prostate-specific membrane antigen-1007 PET/CT and multiparametric MRI for prostate cancer extracapsular extension prediction[J]. BRITISH JOURNAL OF RADIOLOGY,2024,97(1154):408-414.
APA	Pan, Kehua., Yao, Fei., Hong, Weifeng., Xiao, Juan., Bian, Shuying., ... & Yang, Yunjun. (2024). Multimodal radiomics based on 18F-Prostate-specific membrane antigen-1007 PET/CT and multiparametric MRI for prostate cancer extracapsular extension prediction. BRITISH JOURNAL OF RADIOLOGY, 97(1154), 408-414.
MLA	Pan, Kehua,et al."Multimodal radiomics based on 18F-Prostate-specific membrane antigen-1007 PET/CT and multiparametric MRI for prostate cancer extracapsular extension prediction".BRITISH JOURNAL OF RADIOLOGY 97.1154(2024):408-414.