Predictive role of glycocalyx components and MMP-9 in cardiopulmonary bypass patients for ICU stay

doi:10.1016/j.heliyon.2023.e23299

科研成果详情

题名	Predictive role of glycocalyx components and MMP-9 in cardiopulmonary bypass patients for ICU stay
作者	Lin, Lina1; Niu, Mengying 2; Gao, Wei1; Wang, Chundong3; Wu, Qiaolin1; Fang, Fuquan 4; Wang, Yongan 1; Wang, Weijian1
发表日期	2024-01-15
发表期刊	HELIYON 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Glycocalyx MMP-9 CPB ICU stay Coagulation
其他关键词	ENDOTHELIAL GLYCOCALYX
摘要	Background: Shedding of glycocalyx is relevant to worse prognosis in surgical patients, and elevated levels of serum matrix metalloproteinase-9 (MMP-9) are associated with this phenomenon. This study aimed to investigate the dynamic alterations of serum glycocalyx components and MMP-9 during cardiopulmonary bypass (CPB), and evaluate their predictive capacities for prolonged intensive care unit (ICU) stay, as well as their correlation with coagulation dysfunction.Methods: This retrospective study analyzed serum levels of syndecan-1, heparan sulfate (HS), and MMP-9 at different time points during CPB, and assessed their association with prolonged ICU stay and coagulation dysfunction.Results: Syndecan-1, HS, and MMP-9 exhibited divergent changes during CPB. Serum levels of syndecan-1 (AUC = 78.0 %) and MMP-9 (AUC = 78.4 %) were validated as reliable predictors for prolonged ICU stay, surpassing the predictive value of creatinine (AUC = 70.0 %). Syndecan-1 (rho = 0.566, P < 0.01 at T1 and rho = 0.526, P < 0.01 at T2) and HS (rho = 0.403, P < 0.05 at T4) exhibited correlations with activated partial thromboplastin time (APTT) ratio beyond the normal range.Conclusions: Our findings advocate the potential efficacy of serum glycocalyx components and MMP-9 as early predictive indicators for extended ICU stay following cardiac surgery with CPB. Additionally, we observed a correlation between glycocalyx disruption during CPB and coagulation dysfunction. Further studies with expansive cohorts are warranted to consolidate our findings and explore the predictive potential of other glycocalyx components.
资助项目	Health Commission of Zhejiang Province [2010KYA134]; Wenzhou Science and Technology Bureau [Y20210190]
出版者	CELL PRESS
ISSN	2405-8440
EISSN	2405-8440
卷号	10 期号:1
DOI	10.1016/j.heliyon.2023.e23299
页数	10
WOS类目	Multidisciplinary Sciences
WOS研究方向	Science & Technology - Other Topics
WOS记录号	WOS:001135744200001
收录类别	SCIE ; PUBMED ; SCOPUS
在线发表日期	2023-12
URL	查看原文
PubMed ID	38163126
SCOPUSEID	2-s2.0-85179173181
通讯作者地址	[Wang, Weijian]Department of Anesthesiology,The First Affiliated Hospital of Wenzhou Medical University,Zhejiang Province,Wenzhou,325000,China ; [Wang, Yongan]Department of Anesthesiology,The First Affiliated Hospital of Wenzhou Medical University,Zhejiang Province,Wenzhou,325000,China
Scopus学科分类	Multidisciplinary
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/209576
专题	附属第一医院其他_附属东阳医院（东阳市人民医院）
通讯作者	Wang, Yongan; Wang, Weijian
作者单位	1.Department of Anesthesiology,The First Affiliated Hospital of Wenzhou Medical University,Zhejiang Province,Wenzhou,325000,China; 2.Department of Anesthesiology,Peking University Third Hospital,Beijing,100191,China; 3.Department of Anesthesiology,Affiliated Dongyang Hospital of Wenzhou Medical University,Zhejiang,Dongyang,322100,China; 4.Department of Anesthesiology,The First Affiliated Hospital,Zhejiang University School of Medicine,Zhejiang,Hangzhou,310003,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院; 麻醉科
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院; 麻醉科
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Lin, Lina,Niu, Mengying,Gao, Wei,et al. Predictive role of glycocalyx components and MMP-9 in cardiopulmonary bypass patients for ICU stay[J]. HELIYON,2024,10(1).
APA	Lin, Lina., Niu, Mengying., Gao, Wei., Wang, Chundong., Wu, Qiaolin., ... & Wang, Weijian. (2024). Predictive role of glycocalyx components and MMP-9 in cardiopulmonary bypass patients for ICU stay. HELIYON, 10(1).
MLA	Lin, Lina,et al."Predictive role of glycocalyx components and MMP-9 in cardiopulmonary bypass patients for ICU stay".HELIYON 10.1(2024).