Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome

doi:10.1056/NEJMoa1801174

科研成果详情

题名	Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome
作者	Schwartz, G. G.1; Steg, P. G.2,3,5; Szarek, M.6; Bhatt, D. L.8,9; Bittner, V. A.10; Diaz, R.11,21; Edelberg, J. M.12; Goodman, S. G.13,14; Hanotin, C.4; Harrington, R. A.15,90; Jukema, J. W.16; Lecorps, G.4; Mahaffey, K. W.15,93,94; Moryusef, A.12; Pordy, R.7; Quintero, K.17; Roe, M. T.17,18,81,90; Sasiela, W. J.7; Tamby, J. -F.; Tricoci, P.17,90; White, H. D.19,56; Zeiher, A. M.20; Aylward, Philip E.22; Drexel, Heinz 23,167; Sinnaeve, Peter 24; Dilic, Mirza 25; Lopes, Renato D.17,90,232; Gotcheva, Nina N.26,248; Goodman, Shaun G.13; Prieto, Juan-Carlos 27,293; Yong, Huo 28; Lopez-Jaramillo, Patricio 29; Pecin, Ivan 30; Reiner, Zeljko 31; Ostadal, Petr 32,395; Poulsen, Steen Hvitfeldt 33; Viigimaa, Margus 34; Nieminen, Markku S.35; Danchin, Nicolas 36; Chumburidze, Vakhtang 37; Marx, Nikolaus 38; Liberopoulos, Evangelos 39; Montenegro Valdovinos, Pablo Carlos 40; Tse, Hung-Fat 41; Kiss, Robert Gabor 42; Xavier, Denis 43; Zahger, Doron 44; Valgimigli, Marco 45; Kimura, Takeshi 46; Kim, Hyo Soo 47; Kim, Sang-Hyun 48; Erglis, Andrejs 49; Laucevicius, Aleksandras 50; Kedev, Sasko 51; Yusoff, Khalid 52,53; Ramos Lopez, Gabriel Arturo 54; Alings, Marco 55; Halvorsen, Sigrun 57; Correa Flores, Roger M.58; Sy, Rody G.59; Budaj, Andrzej 60; Morais, Joao 61; Dorobantu, Maria 62; Karpov, Yuri 63; Ristic, Arsen D.64; Chua, Terrance 65; Murin, Jan 66; Fras, Zlatko 67,68; Dalby, Anthony J.69; Tunon, Jose 70; de Silva, H. Asita 71; Hagstrom, Emil 72; Muller, Christian 73; Chiang, Chern-En 74,75; Sritara, Piyamitr 76; Guneri, Sema 77; Parkhomenko, Alexander 78; Ray, Kausik K.79; Moriarty, Patrick M.80; Vogel, Robert 82; Chaitman, Bernard 83; Kelsey, Sheryl F.84; Olsson, Anders G.85; Rouleau, Jean-Lucien 86; Simoons, Maarten L.87; Alexander, Karen 88; Meloni, Chiara 17; Rosenson, Robert 89; Sijbrands, Eric J. G.87; Alexander, John H.90; Armaganijan, Luciana 91; Bagai, Akshay 14; Bahit, Maria Cecilia 91; Brennan, J. Matthew 90; Clifton, Shaun 90; DeVore, Adam D.90; Deloatch, Shalonda 90; Dickey, Sheila 90; Dombrowski, Keith 90; Ducrocq, Gregory 92; Eapen, Zubin 90; Endsley, Patricia 90; Eppinger, Arleen 90; Hess, Connie Ng 82; Hlatky, Mark A.93; Jordan, Joseph Dedrick 94; Knowles, Joshua W.93; Kolls, Bradley J.90; Kong, David F.90; Leonardi, Sergio 95; Lillis, Linda 90; Lopes, Renato D.17,90,232; Maron, David J.93; Marcus, Jill 90; Mathews, Robin 90; Mehta, Rajendra H.90; Mentz, Robert J.90; Moreira, Humberto Graner 91; Patel, Chetan B.90; Pereira, Sabrina Bernardez 91; Perkins, Lynn 90; Povsic, Thomas J.90; Puymirat, Etienne 96; Jones, William Schuyler 90; Shah, Bimal R.90; Sherwood, Matthew W.90; Stringfellow, Kenya 90; Sujjavanich, Darin 90; Toma, Mustafa 97; Trotter, Charlene 90; van Diepen, Sean F. P.13; Wilson, Matthew D.90; Yan, Andrew Tze-Kay 14; Schiavi, Lilia B.98; Garrido, Marcelo 99; Alvarisqueta, Andres F.100; Sassone, Sonia A.101; Bordonava, Anselmo P.102; Alves De Lima, Alberto E.103; Schmidberg, Jorge M.104; Duronto, Ernesto A.105; Caruso, Orlando C.106; Novaretto, Leonardo P.107; Angel Hominal, Miguel 108; Montana, Oscar R.109; Caccavo, Alberto 110; Gomez Vilamajo, Oscar A.111; Lorenzatti, Alberto J.112; Cartasegna, Luis R.113; Paterlini, Gustavo A.114; Mackinnon, Ignacio J.115; Caime, Guillermo D.116; Amuchastegui, Marcos 117; Codutti, Oscar R.118; Jure, Horacio O.119; Bono, Julio O. E.120; Hrabar, Adrian D.121; Vallejos, Julio A.122; Ahuad Guerrero, Rodolfo A.123; Novoa, Federico 124; Patocchi, Cristian A.125; Zaidman, Cesar J.126; Giuliano, Maria E.127; Dran, Ricardo D.128; Vico, Marisa L.129; Carnero, Gabriela S.130; Guzman, Pablo N.131; Medrano Allende, Juan C.132; Garcia Brasca, Daniela F.133; Bustamante Labarta, Miguel H.134; Nani, Sebastian 135; Blumberg, Eduardo D. S.136; Colombo, Hugo R.137; Liberman, Alberto 138; Luciardi, Hector L.139; Waisman, Gabriel D.140; Berli, Mario A.141; Garcia Duran, Ruben O.142; Cestari, Horacio G.143; Luquez, Hugo A.144; Giordano, Jorge A.145; Saavedra, Silvia S.146; Waites, Jonathon H.147; Collins, Nicholas 148; Soward, Allan 149; Hii, Chris L. S.150; Shaw, James 151; Arstall, Margaret A.152; Horowitz, John 153; Rogers, James F.154; Colquhoun, David 155; Flores, Romulo E. Oqueli 156; Roberts-Thomson, Philip 157; Raffel, Owen 158; Lehman, Sam J.159; Coverdale, Steven G. M.160; Garrahy, Paul J.161; Starmer, Gregory 162; Sader, Mark 163; Carroll, Patrick A.164; Zweiker, Robert 165; Hoppe, Uta 166; Huber, Kurt 168; Berger, Rudolf 169; Weidinger, Franz 170; Faes, Dirk 171; Hermans, Kurt 172; Pirenne, Bruno 173; Leone, Attilio 174; Hoffer, Etienne 175; Vrolix, Mathias C. M.176; De Wolf, Luc 177; Wollaert, Bart 178; Castadot, Marc 179; Dujardin, Karl 180; Beauloye, Christophe 181; Vervoort, Geert 182; Striekwold, Harry 183; Convens, Carl 184; Roosen, John 185; Barbato, Emanuele 186; Claeys, Marc 187; Cools, Frank 188; Terzic, Ibrahim 189; Barakovic, Fahir 190; Midzic, Zlatko 191; Pojskic, Belma 192; Fazlibegovic, Emir 193; Durak-Nalbantic, Azra 25; Vulic, Dusko 194; Muslibegovic, Adis 195; Reis, Gilmar 196; Sousa, Luciano 197; Nicolau, Jose C.198; Giorgeto, Flavio E.199; Silva, Ricardo P.200; Maia, Lilia Nigro 201; Rech, Rafael 202; Rossi, Paulo R. F.203; Cerqueira, Maria Jose A. G.204; Duda, Norberto 205; Kalil, Renato 206; Kormann, Adrian 207; Abrantes, Jose Antonio M.208; Pimentel Filho, Pedro 209; Soggia, Ana Priscila 210; de Santos, Mayler O. N.211; Neuenschwander, Fernando 212; Bodanese, Luiz C.213; Michalaros, Yorghos L.214,250; Eliaschewitz, Freddy G.215; Vidotti, Maria H.216; Leaes, Paulo E.217; Botelho, Roberto V.218; Kaiser, Sergio 219; Fernandes Manenti, Euler Roberto F.220; Precoma, Dalton B.221; Moura Jorge, Jose C.222; Silva, Pedro G. M. de B.223; Silveira, Jose A.224; Saporito, Wladimir 225,233; Marin Neto, Jose A.226; Feitosa, Gilson S.227; Ritt, Luiz Eduardo F.227; de Souza, Juliana A.228; Costa, Fernando 229; Souza, Weimar K. S. B.230; Reis, Helder J. L.231; Lopes, Renato D.17,90,232; Machado, Leandro 233; Aidar Ayoub, Jose Carlos 234; Todorov, Georgi V.235; Nikolov, Fedya P.236; Velcheva, Elena S.237; Tzekova, Maria L.238; Benov, Haralambi O.239; Petranov, Stanislav L.240; Tumbev, Haralin S.241; Shehova-Yankova, Nina S.242; Markov, Dimitar T.243; Raev, Dimitar H.244; Mollov, Mihail N.245; Kichukov, Kostadin N.246; Ilieva-Pandeva, Katya A.247; Gotcheva, Nina N.26,248; Ivanova, Raya 249; Mincheva, Valentina M.; Lazov, Petar V.251; Dimov, Bojidar I.252; Senaratne, Manohara 253; Stone, James 254; Kornder, Jan ; Pearce, Stephen 255; Dion, Danielle 256; Savard, Daniel 257; Pesant, Yves 258; Pandey, Amritanshu 259; Robinson, Simon 260; Gosselin, Gilbert 261; Vizel, Saul 262; Hoag, Gordon 263; Bourgeois, Ronald 264; Morisset, Anne 265; Sabbah, Eric 266; Sussex, Bruce 267; Kouz, Simon 268; MacDonald, Paul 269; Diaz, Ariel 270; Michaud, Nicolas 271; Fell, David 272; Leung, Raymond 273; Vuurmans, Tycho 274; Lai, Christopher 275; Nigro, Frank 275; Davies, Richard 276; Nogareda, Gustavo 277; Vijayaraghavan, Ram 278; Ducas, John 279; Lepage, Serge 280; Mehta, Shamir 281; Cha, James 282; Dupuis, Robert 283; Fong, Peter 284; Rodes-Cabau, Josep 285; Fadlallah, Hussein 286; Cleveland, David 287; Huynh, Thao 288; Bata, Iqbal 289; Hameed, Adnan 290; Pincetti, Cristian 291; Potthoff, Sergio 292; Acevedo, Monica 294; Aguirre, Arnoldo 295; Vejar, Margarita 296; Yanez, Mario 297; Araneda, Guillermo 298; Fernandez, Mauricio 299; Perez, Luis 300; Varleta, Paola 301; Florenzano, Fernando 302; Huidobro, Laura 303; Raffo, Carlos A.304; Olivares, Claudia 305; Chen, Jiyan 306; Dong, Yugang 307; Huang, Weijian308; Wang, Jianzhong 309; Huang, Shi'An 310; Yao, Zhuhua 311; Cui, Lan 312; Lin, Wenhua 313; Sun, Yuemin 314; Wang, Jingfeng 315; Li, Jianping 316; Zhang, Xuelian 317; Zhu, Hong 318; Chen, Dandan 319; Huang, Lan 320; Dong, Shaohong 321; Su, Guohai 322; Xu, Biao 323; Su, Xi 324; Cheng, Xiaoshu 325; Lin, Jinxiu 326; Zong, Wenxia 327; Li, Huanming 328; Feng, Yi 329; Xu, Dingli 330; Yang, Xinchun 331; Ke, Yuannan 332; Lin, Xuefeng 333; Zhang, Zheng 334; Zheng, Zeqi 335; Luo, Zhurong 336; Chen, Yundai 337; Ding, Chunhua 338; Zheng, Yang 339; Li, Xiaodong 340; Peng, Daoquan 341; Li, Ying 342; Wei, Meng 343; Liu, Shaowen 344; Yu, Yihua 345; Qu, Baiming 346; Jiang, Weihong 347; Zhou, Yujie 348; Zhao, Xingsheng 349; Yuan, Zuyi 350; Guo, Ying 351; Xu, Xiping 352; Shi, Xubo 353; Ge, Junbo 354; Fu, Guosheng 355; Bai, Feng 356; Fang, Weiyi 357; Shou, Xiling ; Yang, Xiangjun 358,359; Wang, Jian'An 360; Jaramillo, Nicolas 361; Vallejo, Gregorio Sanchez 362; Botia, Diana C. Luna 363; Lopez, Rodrigo Botero 364; De Salazar, Dora I. Molina 365; Bonfanti, Alberto J. Cadena 366; Higuera, Juan Diego 367; Silva, Sandra I. Barrera 368; Lozada, Henry J. Garcia 369; Arroyo, Julian A. Coronel 370; Mendoza, Jose L. Accini 371; Ruiz, Ricardo L. Fernandez 372; Fernandez, Angela M.373; Jatin, Fernando G. Manzur 374; Herazo, Aristides Sotomayor 375; Parada, Jeffrey Castellanos 376; Triana, Miguel A. Urina 377; Spinar, Jindrich 378; Horak, David 379; Stasek, Josef 380; Alan, David 381; Machova, Vilma 382; Linhart, Ales 383; Novotny, Vojtech 384; Kaucak, Vladimir 385; Rokyta, Richard 386; Naplava, Robert 387; Coufal, Zdenek 388; Adamkova, Vera 389; Podpera, Ivo 390; Zizka, Jiri 391; Motovska, Zuzana 392; Marusincova, Ivana 393; Svab, Premysl 394; Heinc, Petr 396; Kuchar, Jiri 397; Povolny, Petr 398; Raungaard, Bent 399; Clemmensen, Peter 400; Bang, Lia E.400; May, Ole 401; Bottcher, Morten 401; Hove, Jens D.402; Frost, Lars 403; Gislason, Gunnar 404; Larsen, John 405; Johansen, Peter Betton 406; Hald, Flemming 406; Jeppesen, Jorgen 407; Nielsen, Tonny 408; Kristensen, Kjeld S.409; Walichiewicz, Piotr Maria 409; Lomholdt, Jens D.410; Klausen, Ib C.411; Nielsen, Peter Kaiser 412; Davidsen, Flemming 413; Videbaek, Lars 414; Soots, Mai 415; Vahula, Veiko 416; Hedman, Anu 417; Soopold, sllar 418; Martsin, Kaja 419; Taskinen, Marja-Riitta 420,421; Porthan, Kimmo 420,421; Airaksinen, Juhani K.422; Juonala, Markus 422; Kiviniemi, Tuomas 422; Vikman, Saila 423; Posio, Pirjo 423; Taurio, Jyrki 424; Huikuri, Heikki 425,426; Kaikkonen, Kari 425,426; Coste, Pierre 427; Ferrari, Emile 428; Morel, Olivier 429; Montalescot, Gilles 430; Barone-Rochette, Gilles 431; Mansourati, Jacques 432; Cottin, Yves 433; Steg, Philippe Gabriel 434; Leclercq, Florence 435; Belhassane, Abdelkader 436; Delarche, Nicolas 437; Boccara, Franck 438; Paganelli, Franck 439; Clerc, Jerome 440; Schiele, Francois 441; Aboyans, Victor 442; Probst, Vincent 443; Berland, Jacques 444; Lefevre, Thierry 445; Khintibidze, Irakli 446; Shaburishvili, Tamaz 447; Pagava, Zurab 448; Ghlonti, Ramaz 449; Lominadze, Zaza 450; Khabeishvili, George 447; Hemetsberger, Rayyan 451; Rauch-Kroehnert, Ursula 452; Stratmann, Matthias ; Appel, Karl-Friedrich 453; Schmidt, Ekkehard 454; Omran, Heyder ; Stellbrink, Christoph ; Dorsel, Thomas ; Lianopoulos, Emmanouil ; Marx, Roger ; Zirlik, Andreas ; Schellenberg, Detlev ; Heitzer, Thomas ; Laufs, Ulrich ; Marx, Nikolaus 38; Gielen, Stephan ; Winkelmann, Bernhard ; Behrens, Steffen ; Sydow, Karsten ; Simonis, Gregor ; Muenzel, Thomas ; Werner, Nikos ; Leggewie, Stefan ; Boecker, Dirk ; Braun-Dullaeus, Ruediger ; Toursarkissian, Nicole ; Jeserich, Michael ; Weissbrodt, Matthias ; Schaeufele, Tim ; Weil, Joachim ; Voeller, Heinz ; Waltenberger, Johannes ; Natour, Mohammed ; Steiner, Stephan ; Heidenreich, Lothar ; Gremmler, Uwe ; Killat, Holger ; Patsilinakos, Sotiris ; Kartalis, Athanasios ; Manolis, Athanassios ; Sionis, Dimitrios ; Liberopoulos, Evangelos 39; Skoumas, Ioannis ; Athyros, Vasilios ; Parthenakis, P. I. Frangkiskos ; Hahalis, P. I. Georgios ; Lekakis, John ; Xatzitolios, Apostolos ; Fausto Ovando, Sergio R.; Montenegro Valdovinos, Pablo Carlos 40; Arango Benecke, Juan L.; Rodriguez De Leon, Edgar R.; Yan, Bryan P. Y.; Siu, David C. W.; Turi, Tibor ; Merkely, Bela ; Kiss, Robert Gabor 42; Ungi, Imre ; Lupkovics, Geza ; Nagy, Lajos ; Katona, Andras ; Edes, Istvan ; Muller, Gabor ; Horvath, Ivan ; Kapin, Tibor ; Falukozy, Jozsef ; Kumbla, Mukund ; Sandhu, Manjinder ; Annam, Sharath ; Proddutur, Naveen Reddy ; Premchand, Rajendra K.; Mahajan, Ajaykumar ; Abhyanakar, Atul D.; Kerkar, Prafulla ; Govinda, Ravishankar A.; Oomman, Abraham ; Sinha, Dhurjati ; Patil, Sachin N.; Kahali, Dhiman ; Sawhney, Jitendra ; Joshi, Abhijeet B.; Chaudhary, Sanjeev ; Harkut, Pankaj ; Guha, Santanu ; Porwal, Sanjay ; Jujjuru, Srimannarayana ; Pothineni, Ramesh B.; Monteiro, Minguel R.; Khan, Aziz ; Iyengar, Shamanna S.; Grewal, Jasprakash Singh ; Chopda, Manoj ; Fulwani, Mahesh C.; Patange, Aparna ; Chopra, Vijay K.; Goyal, Naresh K.; Shinde, Rituparna ; Manakshe, Gajendra V.; Patki, Nitin ; Sethi, Sumeet ; Munusamy, Vengatesh ; Karna, Sunil ; Adhyapak, Srilakshmi ; Pandurangi, Ulhas ; Mathur, Rishabh ; Kalashetti, Suhas ; Bhagwat, Ajit ; Raghuraman, Bagirath ; Yerra, Shiv Kumar ; Bhansali, Prasant ; Borse, Rohidas ; Das, Srihari ; Abdullakutty, Jabir ; Saathe, Shireesh ; Palimkar, Priya ; Atar, Shaul ; Shechter, Michael ; Mosseri, Morris ; Arbel, Yaron ; Lotan, Chaim ; Rosenschein, Uri ; Katz, Amos ; Henkin, Yaakov ; Francis, Adi ; Klutstein, Marc ; Nikolsky, Eugenia ; Turgeman, Yoav ; Halabi, Majdi ; Kornowski, Ran ; Jonas, Michael ; Amir, Offer ; Rozenman, Yoseph ; Fuchs, Shmuel ; Hussein, Osamah ; Gavish, Dov ; Vered, Zvi ; Caraco, Yoseph ; Elias, Mazen ; Tov, Naveh ; Piovaccari, Giancarlo ; De Pellegrin, Annamaria ; Guardigli, Gabriele ; Licciardello, Giovanni ; Auguadro, Carla ; Cuccia, Claudio ; Salvioni, Alessandro ; Musumeci, Giuseppe ; Calabro, Paolo ; Novo, Salvatore ; Faggiano, Pompilio ; De Cesare, Nicoletta B.; Berti, Sergio ; Cavallini, Claudio ; Puccioni, Enrico ; Galvani, Marcello ; Tespili, Maurizio ; Piatti, Piermarco ; Palvarini, Michela ; De Luca, Giuseppe ; Violini, Roberto ; De Leo, Alessandro ; Filardi, Pasquale Perrone ; Ferratini, Maurizio ; Dai, Kazuoki ; Kamiya, Haruo ; Ando, Kenji ; Takeda, Yoshihiro ; Morino, Yoshihiro ; Hata, Yoshiki ; Kimura, Kazuo ; Kishi, Koichi ; Michishita, Ichiro ; Uehara, Hiroki ; Higashikata, Toshinori ; Hirayama, Atsushi ; Hirooka, Keiji ; Sakagami, Satoru ; Taguchi, Shuichi ; Koike, Akihiro ; Fujinaga, Hiroyuki ; Koba, Shinji ; Kozuma, Ken ; Kawasaki, Tomohiro ; Ono, Yujiro ; Shimizu, Masatoshi ; Katsuda, Yousuke ; Wada, Atsuyuki ; Shinke, Toshiro ; Ako, Junya ; Fujii, Kenshi ; Takahashi, Toshiyuki ; Sakamoto, Tomohiro ; Furukawa, Yutaka ; Sugino, Hiroshi ; Mano, Toshiaki ; Utsu, Noriaki ; Ito, Kashima ; Haraguchi, Takuya ; Ueda, Yasunori ; Nishibe, Akira ; Fujimoto, Kazuteru ; Yoon, Jung Han ; Park, Hun Sik ; Chae, In-Ho ; Kim, Moo Hyun ; Jeong, Myung Ho ; Rha, Seungwoon ; Kim, Chongjin ; Hong, Taekjong ; Busmane, Arija ; Pontaga, Natalija ; Strelnieks, Aldis ; Mintale, Iveta ; Sime, Iveta ; Petrulioniene, Zaneta ; Kavaliauskiene, Roma ; Jurgaitiene, Ruta ; Sakalyte, Gintare ; Slapikas, Rimvydas ; Norkiene, Sigute ; Misonis, Nerijus ; Kibarskis, Aleksandras ; Kubilius, Raimondas ; Bojovski, Stojko ; Lozance, Nensi ; Kjovkaroski, Aleksandar ; Doncovska, Snezana ; Ong, Tiong Kiam ; Kasim, Sazzli ; Maskon, Oteh ; Kandasamy, Balachandran ; Liew, Houng B.; Mohamed, Wan Mohd Izani Wan ; Garcia Castillo, Armando ; Carrillo Calvillo, Jorge ; Fajardo Campos, Pedro ; Nunez Fragoso, Juan Carlos ; Bayram Llamas, Edmundo Alfredo ; Alcocer Gamba, Marco Antonio ; Carranza Madrigal, Jaime ; Gonzalez Salas, Luis Gerardo ; Lopez Rosas, Enrique ; Gonzalez Diaz, Belinda ; Salcido Vazquez, Eduardo ; Nacoud Ackar, Alfredo ; Llamas Esperon, Guillermo Antonio ; Martinez Sanchez, Carlos Rodolfo ; Guerrero De Leon, Maria ; Suarez Otero, Rodrigo ; Fanghanel Salmon, Guillermo ; Perez Rios, Jesus Antonio ; Garza Ruiz, Jose Angel ; Breedveld, Robert W.; Hoogslag, Pieter A. M.; Suryapranata, Harry ; Oomen, Antonius ; Wiersma, Jacobijne J.; Van Der Wal, Ruud M. A.; Van Huysduynen-Monraats, Pascalle S. Hooft ; Karalis, Ioannis ; Verdel, Gerardus J. E.; Brueren, Bart R. G.; Troquay, Roland P. Th ; Viergever, Eric P.; Al-Windy, Nadea Y. Y.; Bartels, Gerard L.; Cornel, Jan H.; Hermans, Walter R. M.; Herrman, Johannes P. R.; Bos, Robert J.; Groutars, Reginald G. E. J.; Van Der Zwaan, Coenraad C.; Kaplan, Refik ; Ronner, Eelko ; Groenemeijer, Bjorn E.; Bronzwaer, Patrick N. A.; Liem, Anho A. H.; Rensing, Bernard J. W. M.; Bokern, Marcel J. J. A.; Nijmeijer, Remco ; Hersbach, Ferry M. R. J.; Willems, Frank F.; Gosselink, Antonius T. M.; Elliott, John ; Wilkins, Gerard ; Fisher, Raewyn ; Scott, Douglas ; Hart, Hamish ; Stewart, Ralph ; Harding, Scott ; Ternouth, Ian ; Fisher, Nicholas ; Aitken, Denise ; Anscombe, Russell ; Tomala, Tadeusz ; Nygard, Ottar ; Sparby, Jon Arne ; Andersen, Kjell ; Gullestad, Lars ; Jortveit, Jarle ; Munk, Peter S.; Hurtig, Ulf ; Ticona, Jorge R. Calderon ; Velasquez, Julio R. Durand ; Miguel, Sandra A. Negron ; Perez, Enrique S. Sanabria ; Chambilla, Jesus M. Carrion ; Ayala, Carlos A. Chavez ; Leon, Reynaldo P. Castillo ; Gonzales, Rolando J. Vargas ; Zuniga, Jose D. Hernandez ; Cosavalente, Luis A. Camacho ; Mannucci, Jorge E. Bravo ; Navarro, Nassip C. Llerena ; Concha, Yudy M. Roldan ; Chavez, Victor E. Rodriguez ; Hernandez, Henry A. Anchante ; Nunez, Carlos A. Zea ; Ferrolino, Arthur ; Sy, Rosa Allyn G.; Tirador, Louie ; Matiga, Generoso ; Coching, Raul Martin ; Bernan, Alisa ; Rogelio, Gregorio ; Morales, Dante D.; Tan, Edgar ; Wlodarczak, Adrian ; Jaworska, Krystyna ; Skonieczny, Grzegorz ; Pawlowicz, Lidia ; Wojewoda, Pawel ; Busz-Papiez, Benita ; Bednarski, Janusz ; Goch, Aleksander ; Staneta, Pawel ; Dulak, Elzbieta ; Saminski, Krzysztof ; Krasowski, Wlodzimierz ; Sudnik, Wanda ; Zurakowski, Aleksander ; Skorski, Marcin ; Lysek, Roman ; Miklaszewicz, Beata ; Kubica, Jacek ; Lipko, Jan Andrzej ; Kostarska-Srokosz, Edyta ; Piepiorka, Marek ; Drzewiecka, Anna ; Sciborski, Ryszard ; Stasiewski, Arkadiusz ; Blicharski, Tomasz ; Bystryk, Leszek ; Szpajer, Michal ; Korol, Marek ; Czerski, Tomasz ; Mirek-Bryniarska, Ewa ; Gniot, Jacek ; Lubinski, Andrzej ; Gorny, Jerzy ; Franek, Edward ; Monteiro, Pedro ; Bastos, Jose Mesquita ; Pereira, Helder H.; Martins, Dinis ; Seixo, Filipe ; Mendonca, Carlos ; Botelho, Ana ; Minescu, Bogdan ; Istratoaie, Octavian ; Tesloianu, Dan N.; Cristian, Gabriel ; Podoleanu, Cristian G. C.; Constantinescu, Mircea C. A.; Bengus, Cristina M.; Militaru, Constantin ; Rosu, Doina ; Parepa, Irinel R.; Matei, Adrian V.; Alexandru, Tom M.; Shvarts, Yury ; Orlikova, Olga ; Kobalava, Zhanna ; Barbarash, Olga L.; Markov, Valentin ; Lyamina, Nadezhda ; Gordienko, Alexander ; Zrazhevsky, Konstantin ; Vishnevsky, Alexander Y.; Gurevich, Victor ; Stryuk, Raisa ; Lomakin, Nikita V.; Bokarev, Igor ; Shalaev, Sergey ; Khaisheva, Larisa ; Chizhov, Petr ; Viktorova, Inna ; Osokina, Natalya ; Akatova, Evgenia ; Chumakova, Galina ; Libov, Igor ; Voevoda, Mikhail I.; Tretyakova, Tatyana V.; Baranov, Evgeny ; Shustov, Sergey ; Yakushin, Sergey ; Gordeev, Ivan ; Khasanov, Niiaz ; Reshetko, Olga ; Sotnikova, Tatiana ; Molchanova, Olga ; Nikolaev, Konstantin ; Gapon, Liudmila ; Baranova, Elena ; Shogenov, Zaur ; Kosmachova, Elena ; Karpov, Yuriy ; Povzun, Anton ; Egorova, Liudmila ; Tyrenko, Vadim V.; Ivanov, Igor G.; Simic, Dragan 64; Ivanovic, Nikola ; Davidovic, Goran ; Tasic, Nebojsa ; Asanin, Milika R.64; Stojic, Stevo ; Apostolovic, Svetlana R.; Ilic, Stevan ; Putnikovic, Biljana ; Stankovic, Aleksandar ; Arandjelovic, Aleksandra ; Radovanovic, Slavica ; Balinovac, Jovan ; Dincic, Dragan V.; Seferovic, Petar ; Dodic, Slobodan ; Dimkovic, Sinisa ; Poh, Kian-Keong ; Ong, Hean Yee ; Micko, Karol ; Nociar, Jan ; Pella, Daniel ; Fulop, Peter ; Hranai, Marian ; Palka, Juraj ; Mazur, Juraj ; Majercak, Ivan ; Dzupina, Andrej ; Fazekas, Frantisek ; Gonsorcik, Jozef ; Bugan, Viliam ; Selecky, Juraj ; Kamensky, Gabriel ; Strbova, Jaroslava ; Smik, Rudolf ; Dukat, Andrej ; Zuran, Ivan ; Oklukar, Janez ; Suligoj, Natasa Cernic ; Cevc, Matija ; Lipar, Luka ; Cyster, Henry P.; Ranjith, Naresh ; Corbett, Clive ; Bayat, Junaid ; Makotoko, Ellen Makoali ; Kapp, Ilse E.; Basson, Matthys M. de V.; Lottering, Hanlie ; Van Zyl, Louis J.; Sebastian, Peter J.; Pillay, Thayabran ; Saaiman, Jan A.; Commerford, Patrick J.; Cassimjee, Soraya ; Ebrahim, Iftikhar O.; Sarvan, Mahomed ; Mynhardt, Joseph H.; Dalby, Anthony J.69; Reuter, Helmuth ; Moodley, Rajendran ; Vida, Manuel ; Cequier Fillat, Angel R.; Bodi Peris, Vicente ; Fuentes Jimenez, Francisco ; Marin, Francisco ; Cruz Fernandez, Jose M.; Gil-Extremera, Blas ; Worner Diz, Fernando ; Garcia-Dorado, David ; Iniguez, Andres ; Tunon Fernandez, Jose ; Gonzalez-Juanatey, Jose R.; Fernandez Portales, Javier ; Civeira Murillo, Fernando ; Matas Pericas, Laia ; Luis Zamorano, Jose ; De Mora Martin, Manuel ; Bruguera Cortada, Jordi ; Alonso Martin, Joaquin J.; De Berrazueta Fernandez, Jose R.; Diaz Fernandez, Jose Francisco ; Garcia Lledo, Jose Alberto ; Cosin Sales, Juan ; Botas Rodriguez, Javier ; Gusi Tragant, Gabriel ; Benedicto, Amparo ; Gonzalez-Juanatey, Carlos ; Camprubi Potau, Mercedes ; Plaza Perez, Ignacio ; Moris De La Tassa, Cesar ; Loma-Osorio Rincon, Pablo ; Balaguer Recena, Javier ; M Escudier, Juan ; Constantine, Godwin ; Haniffa, Ruvaiz ; Tissera, Nirmali ; Amarasekera, Stanley ; Fernando, Nimali ; Jayawardena, Jayanthimala ; Santharaj, Wijeyasingam ; Ekanayaka, Ruvan ; Mendis, Sepalika ; Senaratne, Vajira ; Mayurathan, Gnanamoorthy ; Sirisena, Thilak ; Rajapaksha, Ajantha ; Herath, Jagath I.; Amarasena, Naomali ; Berglund, Stefan ; Rasmanis, Gundars ; Hagstrom, Emil 72; Witt, Nils ; Mourtzinis, Georgios ; Nicol, Peter ; Hansen, Ole ; Romeo, Stefano ; Jensen, Steen Agergaard ; Torstensson, Ingemar ; Jensen, Steen Agergaard ; Ahremark, Ulf ; Sundelin, Torbjorn ; Moccetti, Tiziano ; Mueller, Christian ; Mach, Francois ; Binder, Ronald ; Chiang, Chern-En 74,75; Tsai, Wei-Chuan ; Ueng, Kwo-Chang ; Lai, Wen-Ter ; Liu, Ming-En ; Hwang, Juey-Jen ; Yin, Wei-Hsian ; Hsieh, I-Chang ; Lin, Wei Hsiang ; Kuo, Jen-Yuan ; Huang, Tsuei-Yuan ; Fang, Chih-Yuan ; Kaewsuwanna, Pinij ; Soonfuang, Wasant ; Jintapakorn, Woravut ; Sukonthasarn, Apichard ; Sritara, Piyamitr 76; Wongpraparut, Nattawut ; Sastravaha, Krisada ; Sansanayudh, Nakarin ; Kehasukcharoen, Wirash ; Piyayotai, Dilok ; Camsari, Ahmet ; Kultursay, Hakan ; Guneri, Sema 77; Mutlu, Bulent ; Ersanli, Murat ; Demirtas, Mustafa ; Kirma, Cevat ; Ural, Ertan ; Koldas, Lale ; Karpenko, Oleksandr ; Prokhorov, Alexander ; Vakaluyk, Ihor ; Myshanych, Halyna ; Reshotko, Dmytro ; Batushkin, Valeriy ; Rudenko, Leonid ; Kovalskyi, Ihor ; Kushnir, Mykola ; Tseluyko, Vira ; Mostovoy, Yuriy ; Stanislavchuk, Mykola ; Kyiak, Yulian ; Karpenko, Yuriy ; Malynovsky, Yaroslav ; Klantsa, Andriy ; Kutniy, Oles ; Amosova, Ekaterina ; Tashchuk, Viktor ; Leshchuk, Oleh ; Parkhomenko, Alexander 78; Rishko, Mykola ; Kopytsya, Mykola ; Yagensky, Andriy ; Vatutin, Mykola ; Bagriy, Andriy ; Barna, Olga M.; Ushakov, Olexiy ; Dzyak, Georgiy ; Goloborodko, Borys ; Rudenko, Anatolii ; Trevelyan, Jasper ; Zaman, Azfar ; Lee, Kaeng ; Moriarty, Andrew ; Aggarwal, Rajesh K.; Clifford, Piers ; Wong, Yuk-Ki ; Iqbal, Syed M. R.; Subkovas, Eduardas ; Braganza, Denise ; Sarkar, David ; Storey, Robert ; Griffiths, Huw ; Mcclure, Sam ; Muthusamy, Rangasamy ; Kurian, John ; Levy, Terry ; Barr, Craig ; Kadr, Honer ; Gerber, Robert ; Simaitis, Audrius ; Soran, Handrean ; Mathur, Anthony ; Brodison, Adrian ; Oliver, Richard ; Mudawi, Telal ; Reynolds, Timothy ; Sharman, David ; Butler, Rob ; Wilkinson, Peter ; Lip, Gregory Y. H.; Halcox, Julian ; Vardi, Gil ; Baldari, Duccio ; Brabham, David ; Treasure, Charles, II ; Dahl, Charles ; Palmer, Bruce ; Wiseman, Alan ; Khan, Abul ; Puri, Sanjeev ; Mohart, Ann Elizabeth ; Ince, Carlos ; Flores, Enrique ; Wright, Scott ; Cheng, Shi-Chi ; Rosenberg, Michael ; Rogers, William, Jr.; Kosinski, Edward ; Forgosh, Les ; Waltman, Jonathan ; Khan, Misal ; Shoukfeh, Mohammad ; Dagher, Georges ; Lieber, Ira ; Kumar, Priya ; East, Cara ; Krichmar, Perry ; White, Lindsey ; Knickelbine, Thomas ; Haldis, Thomas ; Gillespie, Eve ; Suh, David ; Arif, Imran ; Akhter, Faiq ; Carlson, Eric ; D'Urso, Michael ; El-Ahdab, Fadi ; Nelson, William ; Harris, Barry ; Cohen, Steven ; Carter, Luther ; Sabatino, Kenneth ; Haddad, Tariq ; Malik, Amir ; Rao, Sunder ; Mulkay, Angel ; Jovin, Ion ; Klancke, Kim ; Malhotra, Vinay ; Devarapalli, Sai K.; Koren, Michael ; Chandna, Harish ; Dodds, George, III ; Janik, Matthew ; Moran, Joseph ; Sumner, Andrew ; Kobayashi, John ; Davis, William ; Yazdani, Shahram ; Pasquini, John ; Thakkar, Maitreya ; Vedere, Amarnath ; Leimbach, Wayne ; Rider, James ; Singh, Narendra ; Shah, Anil V.; Moriarty, Patrick M.80; Janosik, Denise ; Pepine, Carl ; Berman, Brett ; Gelormini, Joseph ; Daniels, Christopher ; Keating, Friederike ; Kondo, Nicholas I.; Shetty, Sanjay ; Waider, Winfried ; Takata, Theodore ; Abu-Fadel, Mazen ; Shah, Vipul ; Aggarwal, Rahul ; Izzo, Mark ; Kumar, Anil ; Hattler, Brack ; Link, Chad ; Bortnick, Anna ; Kinzfogl, George, III ; Ghitis, Arnold ; Larry, John ; Teufel, Edward ; Kuhlman, Peter ; Mclaurin, Brent ; Zhang, Wenwu ; Thew, Stephen ; Abbas, Jalal ; White, Matthew ; Ranadive, Nandkishore ; Gring, Christian ; Henderson, David ; Schuchard, Timothy ; Farhat, Naim ; Kline, Geoffrey ; Mahal, Sharan ; Whitaker, Jack ; Speirs, Shawn ; Andersen, Rolf ; Daboul, Nizar ; Horwitz, Phillip ; Jafar, Zubair ; Mcgarvey, Joseph, Jr.; Panchal, Vipul ; Voyce, Stephen ; Blok, Thomas ; Sheldon, William ; Azizad, Masoud M.; Schmalfuss, Carsten ; Picone, Mark ; Herzog, William, Jr.; Lindsey, Jason ; Nowins, Rosemary ; Lepor, Norman ; El Shahawy, Mahfouz ; Weintraub, Howard ; Irimpen, Anand ; May, Wade ; Galski, Thomas ; Chu, Alan ; Mody, Freny ; Hodes, Zachary ; Fairlamb, James ; Lambert, Charles, Jr.; Raisinghani, Ajit ; Abbate, Antonio ; King, Marilyn ; Carey, Charles ; Gerber, Jaime ; Younis, Liwa ; Park, Hyeun (Tom); Vidovich, Mladen ; Knutson, Thomas ; Friedman, Dennis ; Chaleff, Fred ; Loussararian, Arthur ; Kimmelstiel, Carey ; Silver, Kevin ; Foster, Malcolm ; Tonnessen, Glen ; Amlani, Mohamadali ; Wali, Andreas ; Malozzi, Christopher ; Wattanakit, Keattiyoat ; O'Donnell, Philip J.; Singal, Dinesh ; Jaffrani, Naseem ; Banuru, Sridhar ; Fisher, Daniel ; Xenakis, Mark ; Perlmutter, Neal ; Bhagwat, Ravi ; Strader, James, Jr.; Akyea-Djamson, Ayim ; Labroo, Ajay ; Lee, Kwan ; Marais, H. John ; Claxton, Edmund, Jr.; Berk, Martin ; Rossi, Peter ; Joshi, Parag ; Khaira, Ajit S.; Kumkumian, Greg ; Lupovitch, Steven ; Purow, Joshua ; Welka, Stephen ; Hoffman, David ; Fischer, Stuart ; Soroka, Eugene ; Eagerton, Donald ; Pancholy, Samir ; Ray, Michael ; Farrar, Michael ; Pollock, Stewart ; French, William J.; Diamantis, Steve ; Gimple, Lawrence ; Schwartz, Steven ; Pereira, Edward ; Spriggs, Douglas ; Strain, Janet ; Vo, Anthony ; Chane, Majed ; Hall, Jason ; Vijay, Nampalli ; Lotun, Kapildeo ; Lester, F. Martin ; Nahhas, Ahed ; Pope, Theodore ; Nager, Paul ; Vohra, Rakesh ; Bashir, Riyaz ; Ahmed, Hinan ; Berlowitz, Michael ; Fishberg, Robert ; Barrucco, Robert ; Yang, Eric ; Radin, Michael ; Sporn, Daniel ; Eisenberg, Steven ; Landzberg, Joel ; Mcgough, Martin ; Turk, Samir ; Schwartz, Michael ; Sundram, P. Sandy ; Jain, Diwakar ; Zainea, Mark ; Bayron, Carlos ; Karlsberg, Ronald ; Lui, Henry ; Keen, William ; Westerhausen, Donald, Jr.; Khurana, Sandeep ; Agarwal, Himanshu ; Birchem, Jessica ; Penny, William, Jr.; Chang, Mark ; Gilbert, John M.; Chalavarya, Gopal ; Eaton, Charles ; Schmedtje, John F., Jr.; Christenson, Stuart ; Denham, Douglas ; Macdonell, Alexander ; Gibson, Paul ; Rahman, Aref ; Al Joundi, Tammam ; Conrad, Gary ; Kotha, Purushotham ; Love, Michael ; Giesler, Gregory ; Rubenstein, Howard ; Akright, Laura ; Schifferdecker, Branislav ; Krawczyk, Justine ; Wells, Terry ; Welker, James ; Foster, Robert ; Gilmore, Richard ; Anderson, Jay ; Jacoby, Douglas ; Harris, Bill ; Gardner, Geraldine ; Dandillaya, Ramprasad ; Vora, Kishor ; Kostis, John ; Hunter, John ; Laxson, David ; Ball, Eric
发表期刊	NEW ENGLAND JOURNAL OF MEDICINE 影响因子和分区
语种	英语
原始文献类型	Article
其他关键词	MYOCARDIAL-INFARCTION ; MONOCLONAL-ANTIBODY ; REDUCING LIPIDS ; TASK-FORCE ; PCSK9 ; MANAGEMENT ; EFFICACY ; SAFETY ; LDL ; ASSOCIATION
摘要	BACKGROUND Patients who have had an acute coronary syndrome are at high risk for recurrent ischemic cardiovascular events. We sought to determine whether alirocumab, a human monoclonal antibody to proprotein convertase subtilisin-kexin type 9 (PCSK9), would improve cardiovascular outcomes after an acute coronary syndrome in patients receiving high-intensity statin therapy. METHODS We conducted a multicenter, randomized, double-blind, placebo-controlled trial involving 18,924 patients who had an acute coronary syndrome 1 to 12 months earlier, had a low-density lipoprotein (LDL) cholesterol level of at least 70 mg per deciliter (1.8 mmol per liter), a non-high-density lipoprotein cholesterol level of at least 100 mg per deciliter (2.6 mmol per liter), or an apolipoprotein B level of at least 80 mg per deciliter, and were receiving statin therapy at a high-intensity dose or at the maximum tolerated dose. Patients were randomly assigned to receive alirocumab subcutaneously at a dose of 75 mg (9462 patients) or matching placebo (9462 patients) every 2 weeks. The dose of alirocumab was adjusted under blinded conditions to target an LDL cholesterol level of 25 to 50 mg per deciliter (0.6 to 1.3 mmol per liter). The primary end point was a composite of death from coronary heart disease, nonfatal myocardial infarction, fatal or nonfatal ischemic stroke, or unstable angina requiring hospitalization. RESULTS The median duration of follow-up was 2.8 years. A composite primary end-point event occurred in 903 patients (9.5%) in the alirocumab group and in 1052 patients (11.1%) in the placebo group (hazard ratio, 0.85; 95% confidence interval [CI], 0.78 to 0.93; P<0.001). A total of 334 patients (3.5%) in the alirocumab group and 392 patients (4.1%) in the placebo group died (hazard ratio, 0.85; 95% CI, 0.73 to 0.98). The absolute benefit of alirocumab with respect to the composite primary end point was greater among patients who had a baseline LDL cholesterol level of 100 mg or more per deciliter than among patients who had a lower baseline level. The incidence of adverse events was similar in the two groups, with the exception of local injection-site reactions (3.8% in the alirocumab group vs. 2.1% in the placebo group). CONCLUSIONS Among patients who had a previous acute coronary syndrome and who were receiving high-intensity statin therapy, the risk of recurrent ischemic cardiovascular events was lower among those who received alirocumab than among those who received placebo.
资助项目	Sanofi; Regeneron PharmaceuticalsRegeneron; Cerenis; Resverlogix; RocheRoche Holding; Medicines Company; BayerBayer AG; MerckMerck & Company; Amarin; ServierServier; Baxter; AstraZenecaAstraZeneca; Bristol-Myers SquibbBristol-Myers Squibb; EisaiEisai Co Ltd; Ethicon; MedtronicMedtronic; Sanofi AventisSanofi-Aventis; PfizerPfizer; Forest Laboratories-AstraZeneca; Ischemix; AmgenAmgen; LillyEli Lilly; ChiesiChiesi Pharmaceuticals Inc; Iron-wood; AbbottAbbott Laboratories; RegeneronRegeneron; PhaseBio; Idorsia; Synaptic; DalCor; TIMI Group; CSL; Apple; Portola; JanssenJohnson & JohnsonJohnson & Johnson USAJanssen Biotech Inc; NovartisNovartis; Johnson JohnsonJohnson & JohnsonJohnson & Johnson USA; Afferent; Cardiva Medical; DaiichiDaiichi Sankyo Company Limited; FerringFerring Pharmaceuticals; GoogleGoogle Incorporated; Luitpold; Tenax; Ferring PharmaceuticalsFerring Pharmaceuticals; Myokardia; Omthera Pharmaceuticals; Pfizer New ZealandPfizer
出版者	MASSACHUSETTS MEDICAL SOC
出版地	WALTHAM
ISSN	0028-4793
EISSN	1533-4406
卷号	379 期号:22 页码:2097-2107
DOI	10.1056/NEJMoa1801174
WOS类目	Medicine, General & Internal
WOS研究方向	General & Internal Medicine
WOS记录号	WOS:000451402500005
收录类别	SCIE ; SCOPUS
发表日期	2018-11-29
URL	查看原文
Pubmed记录号	30403574
Scopus记录号	2-s2.0-85057337718
ESI热点论文	2020-01 ; 2020-03 ; 2020-05 ; 2020-09 ; 2020-11 ; 2021-01
ESI高被引论文	2020-01 ; 2020-03 ; 2020-05 ; 2020-09 ; 2020-11 ; 2021-01 ; 2021-03 ; 2021-05 ; 2021-07 ; 2021-11 ; 2022-01 ; 2022-03 ; 2022-07 ; 2022-09 ; 2022-11 ; 2023-01 ; 2023-03 ; 2023-05 ; 2023-07 ; 2023-09 ; 2023-11 ; 2024-01 ; 2024-03 ; 2024-05
自科自定义期刊分类	T1类
引用统计	被引频次：1335[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/20949
专题	附属第一医院
通讯作者	Schwartz, G. G.
作者单位	1.Univ Colorado, Sch Med, Div Cardiol, Box B130, Aurora, CO 80045 USA; 2.Paris Diderot Univ, Sorbonne Paris Cite, Hop Bichat, AP HP,FACT, Paris, France; 3.INSERM, Unite 1148, Paris, France; 4.Sanofi, Paris, France; 5.Imperial Coll, Royal Brompton Hosp, Natl Heart & Lung Inst, London, England; 6.SUNY Downstate, Sch Publ Hlth, Brooklyn, NY 11203 USA; 7.Regeneron Pharmaceut, Tarrytown, NY USA; 8.Brigham & Womens Hosp, Heart & Vasc Ctr, 75 Francis St, Boston, MA 02115 USA; 9.Harvard Med Sch, Boston, MA USA; 10.Univ Alabama Birmingham, Div Cardiovasc Dis, Birmingham, AL USA; 11.Estudios Cardiol Latinoamer, Inst Cardiovasc Rosario, Rosario, Santa Fe, Argentina; 12.Sanofi, Bridgewater, MA USA; 13.Univ Alberta, Canadian VIGOUR Ctr, Edmonton, AB, Canada; 14.Univ Toronto, St Michaels Hosp, Toronto, ON, Canada; 15.Stanford Univ, Dept Med, Stanford Ctr Clin Res, Stanford, CA 94305 USA; 16.Leiden Univ, Med Ctr, Dept Cardiol, Leiden, Netherlands; 17.Duke Univ, Med Ctr, Duke Clin Res Inst, Durham, NC USA; 18.Duke Univ, Sch Med, Dept Med, Div Cardiol, Durham, NC 27706 USA; 19.Auckland City Hosp, Green Lane Cardiovasc Serv, Auckland, New Zealand; 20.Goethe Univ, Dept Med 3, Frankfurt, Germany; 21.Estudios Cardiol Latinoamer, Rosario, Santa Fe, Argentina; 22.Flinders Univ & Med Ctr, South Australian Hlth & Med Res Inst, Adelaide, SA, Australia; 23.Landeskrankenhaus Feldkirch, Feldkirch, Austria; 24.UZ Leuven, Leuven, Belgium; 25.Univ Clin Ctr Sarajevo, Sarajevo, Bosnia & Herceg; 26.MHAT Natl Cardiol Hosp EAD, Sofia, Bulgaria; 27.Hosp Clin Univ Chile, Santiago, Chile; 28.Peking Univ First Hosp, Beijing, Peoples R China; 29.Fdn Oftalmol Santander FOSCAL, Floridablanca, Colombia; 30.Univ Zagreb, Univ Hosp Ctr Zagreb, Zagreb Sch Med, Zagreb, Croatia; 31.Univ Zagreb, Univ Hosp Ctr Zagreb, Sch Med, Zagreb, Croatia; 32.Na Homolce Hosp, Prague, Czech Republic; 33.Aarhus Univ Hosp Skejby, Aarhus N, Denmark; 34.SA Pohja Eesti Reg Haigla, Tallinn, Estonia; 35.HUCH, Div Cardiol, Heart & Lung Ctr, Helsinki, Finland; 36.FACT, Hop Europeen Georges Pompidou, Paris, France; 37.Chapidze Emergency Cardiol Ctr, Tbilisi, Georgia; 38.Univ Klinikum Aachen, Aachen, Germany; 39.Univ Gen Hosp Ioannina, Ioannina, Greece; 40.Clin Privada, Unidad Diagnost Cardiol, Guatemala City, Guatemala; 41.Univ Hong Kong, Queen Mary Hosp, Hong Kong, Peoples R China; 42.Magyar Honvedseg Egeszsegugyi Kozpont, Budapest, Hungary; 43.St Johns Med Coll, Bangalore, Karnataka, India; 44.Ben Gurion Univ Negev, Soroka Univ Med Ctr, Fac Hlth Sci, Beer Sheva, Israel; 45.Univ Ferrara, Unit Operat Cardiol, Ferrara, Italy; 46.Kyoto Univ, Grad Sch Med, Kyoto, Kyoto, Japan; 47.Seoul Natl Univ Hosp, Seoul, South Korea; 48.SMG Seoul Natl Univ, Boramae Med Ctr, Seoul, South Korea; 49.Pauls Stradins Clin Univ Hosp, Riga, Latvia; 50.Vilnius Univ Hosp, Santaros Klin, Vilnius, Lithuania; 51.Univ Clin Cardiol, Skopje, North Macedonia; 52.Univ Teknol MARA UiTM Selayang Campus, Batu Caves, Malaysia; 53.UCSI Univ, Kuala Lumpur, Malaysia; 54.Med Off, Guadalajara, Jalisco, Mexico; 55.Amphia Ziekenhuis Molengracht, Breda, Netherlands; 56.Auckland City Hosp, Green Lane Cardiovasc Serv, Auckland, New Zealand; 57.Oslo Univ Sykehus HF, Oslo, Norway; 58.Hosp Nacl IV Alberto Sabogal Sologuren, Callao, Peru; 59.Cardinal Santos Med Ctr, San Juan, Philippines; 60.Grochowski Hosp, Postgrad Med Sch, Warsaw, Poland; 61.Ctr Hosp Leiria Pombal, Leiria, Portugal; 62.Clin Emergency Hosp Bucharest, Bucharest, Romania; 63.Russian Cardiol Sci Prod Complex, Moscow, Russia; 64.Clin Ctr Serbia, Belgrade, Serbia; 65.Natl Heart Ctr, Singapore, Singapore; 66.Univ Nemocn Bratislava, Interna Klin 1, Bratislava, Slovakia; 67.Univ Med Ctr Ljubljana, Div Med, Dept Vasc Med, Prevent Cardiol Unit, Ljubljana, Slovenia; 68.Univ Ljubljana, Fac Med, Ljubljana, Slovenia; 69.Milpark Hosp, Johannesburg, South Africa; 70.Fdn Jimenez Diaz, Madrid, Spain; 71.Univ Kelaniya, Clin Trials Unit, Colombo, Sri Lanka; 72.Uppsala Univ Hosp, Uppsala, Sweden; 73.Univ Spital Basel, Basel, Switzerland; 74.Taipei Vet Gen Hosp, Gen Clin Res Ctr, Taipei, Taiwan; 75.Natl Yang Ming Univ, Taipei, Taiwan; 76.Ramathibodi Hosp, Bangkok, Thailand; 77.Dokuz Eylul Univ, Tip Fak, Izmir, Turkey; 78.MD Strazhesko Inst Cardiol AMS Ukraine, Kiev, Ukraine; 79.Imperial Coll London, London, England; 80.Univ Kansas, Med Ctr, Clin Pharmacol, Kansas City, KS 66103 USA; 81.Duke Clin Res Inst, Durham, NC USA; 82.Univ Colorado Denver, Denver, CO USA; 83.St Louis Univ, St Louis Univ Ctr Hlth Outcomes Res, St Louis, MO USA; 84.Univ Pittsburgh, Grad Sch Publ Hlth, Pittsburgh, PA 15260 USA; 85.Linkoping Univ, Dept Med & Hlth, Linkoping, Sweden; 86.Univ Montreal, Inst Cardiol, Montreal, PQ, Canada; 87.Erasmus MC, Rotterdam, Netherlands; 88.Duke Univ, Duke Clin Res Inst, Durham, NC USA; 89.Mt Sinai Sch Med, New York, NY USA; 90.Duke Univ, Durham, NC USA; 91.Brazilian Clin Res Inst, Sao Paulo, Brazil; 92.Hop Bichat Claude Bernard, AP HP, Paris, France; 93.Stanford Univ, Stanford, CA 94305 USA; 94.Univ N Carolina, Chapel Hill, NC USA; 95.Fdn IRCCS Policlin S Matteo, Pavia, Italy; 96.Hop Europeen Georges Pompidou, Paris, France; 97.Univ British Columbia, St Pauls Hosp, Vancouver, BC, Canada; 98.Clin Del Prado, Cordoba, Cordoba, Argentina; 99.Clin Privada Prov, Merlo, Buenos Aires, Argentina; 100.Ctr Invest Med Mar del Plata, Mar Del Plata, Buenos Aires, Argentina; 101.Consultorios Asoc Endocrinol & Inv Clin Aplicad, Caba, Buenos Aires, Argentina; 102.Clin FUSAVIM Privada, Villa Maria, Cordoba, Argentina; 103.Inst Cardiovasc Buenos Aires, Buenos Aires, Buenos Aires, Argentina; 104.Inst Med Aguero, Moron, Buenos Aires, Argentina; 105.Fdn Favaloro Docencia & Invest Med, Caba, Buenos Aires, Argentina; 106.Hosp Cent Mendoza, Mendoza, Mendoza, Argentina; 107.Sanatorio Santa Rosa, Santa Rosa, La Pampa, Argentina; 108.Ctr Invest Clin Litoral, Santa Fe, Santa Fe, Argentina; 109.Dim Clin Privada, Ramos Mejia, Buenos Aires, Argentina; 110.Clin Coronel Suarez, Coronel Suarez, Buenos Aires, Argentina; 111.Sanatorio San Martin SA, Venado Tuerto, Santa Fe, Argentina; 112.Inst Med DAMIC, Cordoba, Cordoba, Argentina; 113.Hosp Italiano La Plata, La Plata, Buenos Aires, Argentina; 114.Invest Clin Tucuman, San Miguel De Tucuman, Tucuman, Argentina; 115.Inst Invest Clin, Mar Del Plata, Buenos Aires, Argentina; 116.Inst Diagnost La Plata, La Plata, Buenos Aires, Argentina; 117.Hosp Privado Ctr Med Cordoba, Cordoba, Cordoba, Argentina; 118.Cordis Inst Corazon, Resistencia, Chaco, Argentina; 119.Clin Chutro SRL, Cordoba, Cordoba, Argentina; 120.Sanat Allende, Cordoba, Cordoba, Argentina; 121.Inst Invest Clin Quilmes, Quilmes, Buenos Aires, Argentina; 122.Inst Cardiol Corrientes, Corrientes, Corrientes, Argentina; 123.Corp Med San Martin, San Martin, Buenos Aires, Argentina; 124.Grp Med Alem, San Isidro, Buenos Aires, Argentina; 125.Hosp Reg Espanol Bahia Blanca, Bahia Blanca, Buenos Aires, Argentina; 126.Ctr Invest & Prevenc Cardiovasc, Caba, Buenos Aires, Argentina; 127.Fdn Estudios Clin, Inst Med, Rosario, Santa Fe, Argentina; 128.Sanat Mariano Pelliza, Olivos, Buenos Aires, Argentina; 129.Inst Invest Clin Zarate, Zarate, Buenos Aires, Argentina; 130.IMEP, Ciudadela, Buenos Aires, Argentina; 131.Sanat San Francisco, Santiago Del Estero, Santiago Estero, Argentina; 132.Clin & Maternidad Suizo Argentina, Caba, Buenos Aires, Argentina; 133.Hosp Italiano, Cordoba, Cordoba, Argentina; 134.Ctr Med Lebensohn, Junin, Buenos Aires, Argentina; 135.Clin Olivos, Olivos, Buenos Aires, Argentina; 136.Medeos, Caba, Buenos Aires, Argentina; 137.Clin Colombo, Cordoba, Cordoba, Argentina; 138.Inst Privado Invest Clin Cordoba, Cordoba, Cordoba, Argentina; 139.Ctr Modelo Cardiol, San Miguel De Tucuman, Tucuman, Argentina; 140.Hosp Italiano Buenos Aires, Buenos Aires, Buenos Aires, Argentina; 141.Hosp Prov Dr Jose Maria Cullen, Santa Fe, Santa Fe, Argentina; 142.Inst Invest Clin San Nicolas, San Nicolas, Buenos Aires, Argentina; 143.Sanatorio Guemes, Caba, Buenos Aires, Argentina; 144.Ctr Med Luquez, Cordoba, Cordoba, Argentina; 145.Clin Inst Med Adrogue, Almirante Brown, Buenos Aires, Argentina; 146.Sanat Parque SA, Salta, Salta, Argentina; 147.Coffs Harbour Hlth Campus, Coffs Harbour, NSW, Australia; 148.John Hunter Hosp, New Lambton Hts, NSW, Australia; 149.Mildura Cardiol, Mildura, Vic, Australia; 150.Calvary Clin, Bruce, ACT, Australia; 151.Alfred Hosp, Prahran, Vic, Australia; 152.Northern Cardiol & Specialist Clin, Elizabeth Vale, SA, Australia; 153.Queen Elizabeth Hosp, Woodville, SA, Australia; 154.Gosford Hosp, Gosford, NSW, Australia; 155.Wesley Med Ctr, Auchenflower, Qld, Australia; 156.Ballarat Hlth Serv, Ballarat, Vic, Australia; 157.Royal Hobart Hosp, Hobart, Tas, Australia; 158.Prince Charles Hosp, Chermside, Qld, Australia; 159.Adelaide Med Res, Ashford, SA, Australia; 160.Nambour Gen Hosp, Nambour, Qld, Australia; 161.Princess Alexandra Hosp, Woolloongabba, Qld, Australia; 162.Cairns Hosp, Cairns, Qld, Australia; 163.St George Hosp, Kogarah, NSW, Australia; 164.Redcliffe Hosp, Redcliffe, Qld, Australia; 165.Univ Klinikum Graz, Graz, Austria; 166.Univ Klinikum Salzburg, Salzburg, Austria; 167.Vorarlberg Inst Vaskulare Forsch VIVIT, Feldkirch, Austria; 168.Wilhelminenspital Stadt Wien, Vienna, Austria; 169.KH Barmherzigen Bruder Eisenstadt, Kardiol & Nephrol, Eisenstadt, Austria; 170.Krankenanstalt Rudolfstiftung Stadt Wien, Vienna, Austria; 171.Mariaziekenhuis Vzw, Overpelt, Belgium; 172.AZ St Lucas, Ghent, Belgium; 173.Clin St Pierre, Ottignies, Belgium; 174.CHU Tivoli, La Louviere, Belgium; 175.CHR Citadelle, Liege, Belgium; 176.ZOL, Genk, Belgium; 177.Private Practice, Tienen, Belgium; 178.ZNA Stuivenberg, Antwerp, Belgium; 179.Clin St Jean, Brussels, Belgium; 180.AZ Delta, Roeselare, Belgium; 181.UCL St Luc, Brussels, Belgium; 182.AZ St Maarten, Mechelen, Belgium; 183.Heilig Hart Ziekenhuis, Mol, Belgium; 184.ZNA Middelheim, Antwerp, Belgium; 185.Imelda Hosp, Bonheiden, Belgium; 186.OL Vrouwziekenhuis Campus Aalst, Aalst, Belgium; 187.UZ Antwerpen, Edegem, Belgium; 188.AZ Klina, Brasschaat, Belgium; 189.Heart Ctr BH, Tuzla, Bosnia & Herceg; 190.Univ Med Ctr Tuzla, Tuzla, Bosnia & Herceg; 191.Cantonal Hosp Dr Irfan Ljubijank Bihac, Bihac, Bosnia & Herceg; 192.Cantonal Hosp Zenica, Zenica, Bosnia & Herceg; 193.Univ Clin Hosp Mostar, Mostar, Bosnia & Herceg; 194.Clin Ctr Banja Luka, Banja Luka, Bosnia & Herceg; 195.Reg Med Ctr Dr Safet Mujic, Mostar, Bosnia & Herceg; 196.CARDRESEARCH Cardiol Assistencial & Pesquisa, Belo Horizonte, MG, Brazil; 197.Hosp Coracao Brasil, Brasilia, DF, Brazil; 198.INCOR Inst Coracao, Sao Paulo, Brazil; 199.Hosp Sao Francisco De Assis, Belo Horizonte, MG, Brazil; 200.Hosp Univ Walter Cantidio, Fortaleza, Ceara, Brazil; 201.Hosp Base Sao Jose Rio Preto, Sao Paulo, Brazil; 202.Hosp Univ Ulbra, Canoas, Brazil; 203.Hosp Evangelico Curitiba, Curitiba, Parana, Brazil; 204.Inst Ensino Pesquisa Clin Ceara Ltda, Fortaleza, Ceara, Brazil; 205.Hosp Sao Vicente De Paulo, Passo Fundo, RS, Brazil; 206.Inst Cardiol Do Rio Grande Do Sul, Porto Alegre, RS, Brazil; 207.Hosp Santa Isabel, Soc Div Providencia, Blumenau, Santa Catarina, Brazil; 208.Santa Casa Misericordia Pelotas, Pelotas, RS, Brazil; 209.Hosp Nossa Senhora Conceicao, Porto Alegre, RS, Brazil; 210.Soc Beneficiente Senhoras Hosp Sirio Libanes, Sao Paulo, Brazil; 211.Ctr Cardiol & Radiol Intervencionista LTDA, Aparecida Goiania, Brazil; 212.Hosp Vera Cruz NUPEC, Belo Horizonte, MG, Brazil; 213.Hosp Sao Lucas PUCRS, Porto Alegre, RS, Brazil; 214.Inst Ensino Consultoria & Pesquisa Clin LTDA ME, Belo Horizonte, MG, Brazil; 215.CPCLIN, Sao Paulo, Brazil; 216.Clin LOEMA, Campinas, Brazil; 217.Santa Casa Porto Alegre, Porto Alegre, RS, Brazil; 218.Inst Coracao Triangulo, Uberlandia, MG, Brazil; 219.CCBR Brasil, Rio De Janeiro, Brazil; 220.IMV Inst Med Vasc Hosp Mae de Deus, Porto Alegre, RS, Brazil; 221.Soc Hosp Angelina Caron, Campina Grande Do Sul, Parana, Brazil; 222.Santa Casa Curitiba, Curitiba, Parana, Brazil; 223.Esho Empresa Serv Hosp SA, Sao Paulo, SP, Brazil; 224.Fac Med ABC CEMEC, Sao Bernardo Do Campo, SP, Brazil; 225.Inst Molestias Cardiovasc Tatui IMC, Tatui, SP, Brazil; 226.HCFMRP, Riberao, Preto, Brazil; 227.Hosp Santa Izabel Santa Casa Misericordia Bahia, Salvador, BA, Brazil; 228.Ctr Cardiol Clin & Pesquisa Dra Juliana Souz, Brasilia, DF, Brazil; 229.FGM Clin Paulista Doencas Cardiovasc, Sao Paulo, Brazil; 230.Barroso & Sebba Ltda, Goiania, Go, Brazil; 231.Hosp Clin Gaspar Vianna, Belem, Para, Brazil; 232.Univ Fed Sao Paulo UNIFESP EPM, Sao Paulo, Brazil; 233.Hosp Estadual Mario Covas, Santo Andre, Brazil; 234.Inst Molestias Cardiovasc IMC Sao Jose do Rio Pre, Sao Jose Do Rio Preto, Brazil; 235.2 MHAT, Sofia, Bulgaria; 236.Univ Multiprofile Hosp Act Treatment Sveti Georgi, Plovdiv, Bulgaria; 237.Specialized Hosp Act Treatment Cardiol, Pleven, Bulgaria; 238.UMHAT Dr Georgi Stranski, Pleven, Bulgaria; 239.Multiprof Distr Hosp Act Treatment Dr St Cherkezo, Veliko Tarnovo, Bulgaria; 240.Multiprofile Hosp Act Treatment Burgas AD, Burgas, Bulgaria; 241.Specialized Hosp Act Cardio Treatment Cardiolife, Varna, Bulgaria; 242.MHAT Bratan Shukerov AD, Cardio Dept Inrtens Unite, Smoljan, Bulgaria; 243.UMHAT Tzaritza Yoanna ISUL EAD, Sofia, Bulgaria; 244.MHAT Sveti Vrach EOOD, Sandanski, Bulgaria; 245.First Multiprofile Hosp Act Treatment Sofia EAD, Sofia, Bulgaria; 246.MHAT Lyulin EAD Dept Internal Dis, Sofia, Bulgaria; 247.MHAT Blagoevgrad AD, Blagoevgrad, Bulgaria; 248.MHAT Natl Cardiol Hosp EAD, Sofia, Bulgaria; 249.UMHAT Alexandrovska EAD, Sofia, Bulgaria; 250.NMT Hosp Tsar Boris III, Sofia, Bulgaria; 251.Multiprofile Hosp Act Treatment Pazardzhik AD, Pazardzhik, Bulgaria; 252.Fifth MHAT Sofia EAD, Sofia, Bulgaria; 253.Dr MPJ Senaratne Professional Corp, Edmonton, AB, Canada; 254.TotalCardiology, Calgary, AB, Canada; 255.Surrey Mem Hosp, Surrey, BC, Canada; 256.Ctr Hosp Beauce Etchemin, St Georges De Beauce, PQ, Canada; 257.CardioVasc HR, St Jean, PQ, Canada; 258.St Jerome Med Res Inc, St Jerome, PQ, Canada; 259.Cambridge Cardiac Care Ctr, Cambridge, ON, Canada; 260.Victoria Heart Inst Fdn, Victoria, BC, Canada; 261.Ctr Hosp Pierre Le Gardeur, Terrebonne, PQ, Canada; 262.Vizel Cardiac Res, Cambridge, ON, Canada; 263.Discovery Clin Serv, Victoria, BC, Canada; 264.GA Res Associates Ltd, Moncton, NB, Canada; 265.Ctr Sante & Serv Sociaux Haute Yamaska, Granby, PQ, Canada; 266.Ctr Depistage & Rech Cardiovasc Rive Sud, Longueuil, PQ, Canada; 267.Gen Hosp Hlth Sci Ctr, St John, NF, Canada; 268.Ctr Hosp Reg Lanaudiere, Joliette, PQ, Canada; 269.Cape Breton Reg Hosp, Sydney, NS, Canada; 270.Ctr Hosp Reg Trois Rivieres, Trois Rivieres, PQ, Canada; 271.Clin Cardiol Levis, Levis, PQ, Canada; 272.Newmarket Cardiol Res Grp, Newmarket, ON, Canada; 273.Royal Alexandra Hosp, Edmonton, AB, Canada; 274.Royal Columbian Hosp, New Westminster, BC, Canada; 275.Thunder Bay Reg Hlth Sci Ctr, Thunder Bay, ON, Canada; 276.Ottawa Heart Inst, Ottawa, ON, Canada; 277.Red Deer Reg Hosp Ctr, Red Deer, AB, Canada; 278.Scarborough Cardiol Res, Scarborough, ON, Canada; 279.St Boniface Gen Hosp, Winnipeg, MB, Canada; 280.Hotel Dieu Ctr Hosp Univ Sherbrooke, Sherbrooke, PQ, Canada; 281.Hamilton Gen Hosp, Hamilton, ON, Canada; 282.Lakeridge Hlth Oshawa, Oshawa, ON, Canada; 283.Ctr Sante & Serv Sociaux Reg Thetford Rech, Thetford Mines, PQ, Canada; 284.St Johns Hosp, St John, NB, Canada; 285.Laval Hosp, Quebec Heart Inst, Quebec City, PQ, Canada; 286.Rech GCP Res, Montreal, PQ, Canada; 287.Penticton Reg Hosp, Penticton, BC, Canada; 288.Montreal Gen Hosp, Montreal, PQ, Canada; 289.Queen Elizabeth 2 Hlth Sci Ctr, Halifax, NS, Canada; 290.Med Profess Corp, St Catharines, ON, Canada; 291.Ctr Invest Clin Cics, Temuco, Chile; 292.Corp Beneficencia Osorno, Osorno, Chile; 293.Hosp Clin Univ Chile, Santiago, Chile; 294.Univ Catolica, Ctr Invest Clin, Santiago, Chile; 295.Hosp Barros Luco, Santiago, Chile; 296.Hosp Salvador, Santiago, Chile; 297.Hosp Naval Almirante Nef Vina del Mar, Vina Del Mar, Chile; 298.Hosp Clin Magallanes, Punta Arenas, Chile; 299.Clin Alemana Santiago, Santiago, Chile; 300.Hosp Clin Reg Dr Guillermo Grant Benavente, Concepcion, Chile; 301.Psicomed Clin & Res Grp, Santiago, Chile; 302.Biomed Res Grp, Santiago, Chile; 303.Clin Univ Catolica Maule, Talca, Chile; 304.Estudios Clin V Reg Ltda, Vina Del Mar, Chile; 305.Hosp & CRS El Pino, Santiago, Chile; 306.Guangdong Gen Hosp, Guangzhou, Guangdong, Peoples R China; 307.Sun Yat Sen Univ, Affiliated Hosp 1, Guangzhou, Guangdong, Peoples R China; 308.Wenzhou Med Univ, Affiliated Hosp 1, Wenzhou, Peoples R China; 309.Siping Cent Peoples Hosp, Siping, Peoples R China; 310.Guangdong Med Univ, Affiliated Hosp, Zhanjiang, Peoples R China; 311.Tianjin Union Med Ctr, Tianjin, Peoples R China; 312.Yanbian Univ Hosp, Yanji, Peoples R China; 313.TEDA Int Cardiovasc Hosp, Tianjin, Peoples R China; 314.Tianjin Med Univ, Gen Hosp, Tianjin, Peoples R China; 315.Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Guangzhou, Guangdong, Peoples R China; 316.Peking Univ, Hosp 1, Beijing, Peoples R China; 317.Jilin Prov Peoples Hosp, Changchun, Jilin, Peoples R China; 318.Xuzhou Med Coll, Affiliated Hosp, Xuzhou, Jiangsu, Peoples R China; 319.Guizhou Prov Peoples Hosp, Guiyang, Guizhou, Peoples R China; 320.Third Mil Med Univ, Xinqiao Hosp, Chongqing, Peoples R China; 321.Shenzhen Peoples Hosp, Shenzhen, Peoples R China; 322.Shandong Univ, Jinan Cent Hosp Affiliated, Jinan, Shandong, Peoples R China; 323.Affiliated Hosp NJMU, Nanjing Drum Tower Hosp, Nanjing, Jiangsu, Peoples R China; 324.Wuhan Asian Heart Hosp, Wuhan, Hubei, Peoples R China; 325.Nanchang Univ, Affiliated Hosp 2, Nanchang, Jiangxi, Peoples R China; 326.Fujian Med Univ, Affiliated Hosp 1, Fuzhou, Fujian, Peoples R China; 327.Third Peoples Hosp Hubei Prov, Wuhan, Hubei, Peoples R China; 328.Tianjin 4th Ctr Hosp, Tianjin, Peoples R China; 329.Southeast Univ, Zhongda Hosp, Nanjing, Jiangsu, Peoples R China; 330.Southern Med Univ, Nanfang Hosp, Guangzhou, Guangdong, Peoples R China; 331.Beijing Chaoyang Hosp, Beijing, Peoples R China; 332.China Japan Friendship Hosp, Beijing, Peoples R China; 333.Baotou Med Coll, Affiliated Hosp 1, Baotou, Peoples R China; 334.Lanzhou Univ, Hosp 1, Lanzhou, Gansu, Peoples R China; 335.Nanchang Univ, Affiliated Hosp 1, Nanchang, Jiangxi, Peoples R China; 336.Nanjing Mil Command, Fuzhou Gen Hosp, Nanjing, Jiangsu, Peoples R China; 337.Chinese Peoples Liberat Army Gen Hosp, Beijing, Peoples R China; 338.China Aerosp Corp, Cent Hosp, Beijing, Peoples R China; 339.Jilin Univ, Hosp 1, Changchun, Jilin, Peoples R China; 340.China Med Univ, Shengjing Hosp, Shenyang, Liaoning, Peoples R China; 341.Cent South Univ, Xiangya Hosp 2, Changsha, Hunan, Peoples R China; 342.Shanghai East Hosp, Shanghai, Peoples R China; 343.Shanghai Sixth Peoples Hosp, Shanghai, Peoples R China; 344.Shanghai First Peoples Hosp, Shanghai, Peoples R China; 345.Zhejiang Hosp, Hangzhou, Zhejiang, Peoples R China; 346.Zhejiang Prov Peoples Hosp, Hangzhou, Zhejiang, Peoples R China; 347.Cent South Univ, Xiangya Hosp 3, Changsha, Hunan, Peoples R China; 348.Capital Med Univ, Beijing Anzhen Hosp, Beijing, Peoples R China; 349.Inner Mongolia Peoples Hosp, Hohhot, Peoples R China; 350.Xi An Jiao Tong Univ, Affiliated Hosp 1, Xian, Shaanxi, Peoples R China; 351.Hunan Prov Peoples Hosp, Changsha, Hunan, Peoples R China; 352.First Peoples Hosp Yueyang, Yueyang, Peoples R China; 353.Capital Med Univ, Beijing Tongren Hosp, Beijing, Peoples R China; 354.Fudan Univ, Zhongshan Hosp, Shanghai, Peoples R China; 355.Zhejiang Univ, Sir Run Run Shaw Hosp, Hangzhou, Zhejiang, Peoples R China; 356.Lanzhou Univ, Hosp 2, Lanzhou, Gansu, Peoples R China; 357.Shanghai Jiao Tong Univ, Shanghai Chest Hosp, Shanghai, Peoples R China; 358.Shaanxi Prov Peoples Hosp, Xian, Shaanxi, Peoples R China; 359.Soochow Univ, Affiliated Hosp 1, Suzhou, Peoples R China; 360.Zhejiang Univ, Affiliated Hosp 2, Hangzhou, Zhejiang, Peoples R China; 361.Ctr Med Ejercicio & Rehabilitac Cardiaca, Medellin, Colombia; 362.Fdn Cardiomet Eje Cafetero CEQUIN, Armenia, Quindio, Colombia; 363.Hosp Santa Clara, Bogota, Colombia; 364.IPS Rodrigo Botero SAS, Medellin, Colombia; 365.Asociac IPS Med Internistas Caldas, Manizales, Colombia; 366.Clin Costa ltda, Barranquilla, Colombia; 367.Fdn Oftalmolog FOSCAL, Bucaramanga, Colombia; 368.Caja Compensac Familiar CAFAM, Bogota, Colombia; 369.Fdn Ctr Invest Biomed Riescard, Espinal Tolima, Colombia; 370.IPS Ctr Med Julian Coronel SA, Cali, Valle, Colombia; 371.IPS Ctr Cient Asistencial Jose Luis Accini SAS, Barranquilla, Colombia; 372.Ctr Cardiovasc Colombiano Clin Santa Maria, Medellin, Colombia; 373.Ctr Med Imbanaco Cali SA, Cali, Valle, Colombia; 374.Ctr Diagnost Cardiol LTDA, Cartagena, Colombia; 375.Ctr Cardiovasc Aristides Sotomayor Santa Lucia SA, Cartagena, Bolivar, Colombia; 376.SIMEDICS IPS SAS, Bogota, Colombia; 377.Fdn Caribe Invest Biomed, Barranquilla, Colombia; 378.FN Brno, Brno, Czech Republic; 379.Krajska Nemocnice Liberec, Liberec, Czech Republic; 380.Fak Nemocnice Hradec Kralove, Hradec Kralove, Czech Republic; 381.Fak Nemocnice Motole, Prague, Czech Republic; 382.InterkardioML SRO, Interni Kardiol Ambulance, Marianske Lazne, Czech Republic; 383.Vseobecna Fak Nemocnice Praze, Prague, Czech Republic; 384.Nemocnice Pardubickeho Kraje AS, Pardubice, Czech Republic; 385.Mestska Nemocnice Ostrava, Ostrava, Czech Republic; 386.Fak Nemocnice Plzen, Plzen, Czech Republic; 387.Ctr Choroby Srdce Cev, Kromeriz, Czech Republic; 388.Krajska Nemocnice Tomase Bati AS, Zlin, Czech Republic; 389.Inst Klin Expt Med, Prague, Czech Republic; 390.Oblastni Nemocnice Kladno AS, Kladno, Czech Republic; 391.Thomayerova Nemocnice, Prague, Czech Republic; 392.Fak Nemocnice Kralovske Vinohrady, Prague, Czech Republic; 393.KARDIO SEVER SRO, Ceska Lipa, Czech Republic; 394.Kardiol Ambulance, Rakovnik, Czech Republic; 395.Nemocnice Na Homolce, Prague, Czech Republic; 396.Fak Nemocnice Olomouc, Olomouc, Czech Republic; 397.Kardiol SRO, Cesky Krumlov, Czech Republic; 398.Cardioctr Kladno SRO, PP Klin Kladno, Kladno, Czech Republic; 399.Dep Cardiol, Aalborg, Denmark; 400.Rigshosp Hjertecentret, Copenhagen, Denmark; 401.Region Hosp Herning, Herning, Denmark; 402.Hvidovre Univ Hosp, Hvidovre, Denmark; 403.Reg Hosp Silkeborg, Silkeborg, Denmark; 404.Gentofte Univ Hosp, Hellerup, Denmark; 405.Naestved Sygehus, Naestved, Denmark; 406.Sygehus Lillebaelt, Vejle Sygehus, Vejle, Denmark; 407.Glostrup Cty Hosp, Glostrup, Denmark; 408.Sjaellands Univ Hosp Koge, Koge, Denmark; 409.Holbaek Sygehus, Holbaek, Denmark; 410.Slagelse Sygehus, Slagelse, Denmark; 411.Reg Hosp Viborg, Viborg, Denmark; 412.Hillerod Hosp, Hillerod, Denmark; 413.Sygehus Sonderjylland, Aabenraa, Denmark; 414.Odense Univ Hosp, Odense C, Denmark; 415.SA Viljandi Haigla, Viljandimaa, Estonia; 416.SA Parnu Haigla, Parnu, Estonia; 417.AS Ida Tallinna Keskhaigla, Tallinn, Estonia; 418.SA Tartu Ulikooli Kliinikum, Tartu, Estonia; 419.Mustamae Tervisekeskus OU, Tallinn, Estonia; 420.Helsinki Univ Hosp, Biomed, Helsinki, Finland; 421.Helsinki Univ Hosp, Div Cardiol, Helsinki, Finland; 422.Turku Univ Hosp, Ctr Heart, Turku, Finland; 423.Tampere Univ Hosp, Ctr Heart, Tampere, Finland; 424.Tampere Univ Hosp, Internal Med, Tampere, Finland; 425.Univ Hosp Oulu, Oulu, Finland; 426.Univ Oulu, Oulu, Finland; 427.Hop Cardiol Haut Leveque, Pessac, France; 428.Hop Louis Pasteur, Nice, France; 429.Nouvel Hop Civil, Strasbourg, France; 430.Hop La Pitie Salpetriere, Paris, France; 431.CHU Albert Michallon, Grenoble, France; 432.CHU Brest, Hop Cavale Blanche, Brest, France; 433.CHU Dijon Bocage Cent, Dijon, France; 434.Hop Bichat Claude Bernard, Paris, France; 435.Hop Arnaud Villeneuve, Montpellier, France; 436.Ctr Hosp Cambrai, Cambrai, France; 437.Ctr Hosp Gen, Pau, France; 438.Hop St Antoine, Paris, France; 439.Hop Nord Marseille, Marseille, France; 440.CH Compiegne Noyon, Compiegne, France; 441.CHU Jean Minjoz, Besancon, France; 442.CHU Dupuytren, Limoges, France; 443.CHU Nantes, Nantes, France; 444.Clin St Hilaire, Rouen, France; 445.Inst Hosp Jacques Cartier, Massy, France; 446.Aleksandr Aladashvili Clin LLC, Tbilisi, Georgia; 447.Tbilisi Heart & Vasc Clin Ltd, Tbilisi, Georgia; 448.Ctr Vasc & Heart Dis, Tbilisi, Georgia; 449.Unimed Ajara Batumi Refferal Hosp, Batumi, Georgia; 450.LTD Clin LJ, Kutaisi, Georgia; 451.St Johannes Hosp, Dortmund, Germany; 452.Charite Univ Med Campus Benjamin Franklin, Berlin, Germany; 453.Studienzentrum Dr Appel, Kassel, Germany; 454.Cardiologicum Hamburg, Hamburg, Germany;
推荐引用方式 GB/T 7714	Schwartz, G. G.,Steg, P. G.,Szarek, M.,et al. Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome[J]. NEW ENGLAND JOURNAL OF MEDICINE,2018,379(22):2097-2107.
APA	Schwartz, G. G.., Steg, P. G.., Szarek, M.., Bhatt, D. L.., Bittner, V. A.., ... & Ball, Eric. (2018). Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome. NEW ENGLAND JOURNAL OF MEDICINE, 379(22), 2097-2107.
MLA	Schwartz, G. G.,et al."Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome".NEW ENGLAND JOURNAL OF MEDICINE 379.22(2018):2097-2107.