题名 | Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals |
作者 | Lee, James J.1; Wedow, Robbee2,3,4; Okbay, Aysu5,6; Kong, Edward7; Maghzian, Omeed7; Zacher, Meghan8; Nguyen-Viet, Tuan Anh9; Bowers, Peter7; Sidorenko, Julia10,11; Karlsson Linnér, Richard5,6,12; Fontana, Mark Alan9,13; Kundu, Tushar9; Lee, Chanwook7; Li, Hui7; Li, Ruoxi9; Royer, Rebecca9; Walters, Raymond K.16,17; Willoughby, Emily A.1; Yengo, Loïc10; Agee, Michelle21; Alipanahi, Babak21; Auton, Adam21; Bell, Robert K.21; Bryc, Katarzyna21; Elson, Sarah L.21; Fontanillas, Pierre21; Hinds, David A.21; McCreight, Jennifer C.21; Huber, Karen E.21; Litterman, Nadia K.21; McIntyre, Matthew H.21; Mountain, Joanna L.21; Noblin, Elizabeth S.21; Northover, Carrie A. M.21; Pitts, Steven J.21; Sathirapongsasuti, J. Fah21; Sazonova, Olga V.21; Shelton, Janie F.21; Shringarpure, Suyash21; Tian, Chao21; Vacic, Vladimir21; Wilson, Catherine H.21; Beauchamp, Jonathan P.41; Pers, Tune H.14,15; Rietveld, Cornelius A.12,56,57; Chen, Guo-Bo52; Emilsson, Valur58,59; Meddens, S. Fleur W.5,12,60; Oskarsson, Sven47; Pickrell, Joseph K.61; Thom, Kevin49; Timshel, Pascal14,15; Vlaming, Ronald de12,56,57; Abdellaoui, Abdel62; Ahluwalia, Tarunveer S.14,63,64; Bacelis, Jonas65; Baumbach, Clemens66,67; Bjornsdottir, Gyda68; Brandsma, Johannes H.69; Concas, Maria Pina70; Derringer, Jaime71; Furlotte, Nicholas A.21; Galesloot, Tessel E.72; Girotto, Giorgia73; Gupta, Richa74; Hall, Leanne M.75,76; Harris, Sarah E.38,76; Hofer, Edith77,78; Horikoshi, Momoko79,80; Huffman, Jennifer E.32; Kaasik, Kadri81; Kalafati, Ioanna P.82; Karlsson, Robert46; Kong, Augustine68; Lahti, Jari81,83; van der Lee, Sven J.57; Leeuw, Christiaan de5,84; Lind, Penelope A.85; Lindgren, Karl-Oskar47; Liu, Tian86; Mangino, Massimo87,88; Marten, Jonathan32; Mihailov, Evelin11; Miller, Michael B.1; van der Most, Peter J.89; Oldmeadow, Christopher90,91; Payton, Antony92,93; Pervjakova, Natalia11,94; Peyrot, Wouter J.95; Qian, Yong96; Raitakari, Olli97; Rueedi, Rico98,99; Salvi, Erika100; Schmidt, Börge101; Schraut, Katharina E.19; Shi, Jianxin102; Smith, Albert V.58,103; Poot, Raymond A.69; St Pourcain, Beate104,105; Teumer, Alexander106; Thorleifsson, Gudmar68; Verweij, Niek107; Vuckovic, Dragana73; Wellmann, Juergen108; Westra, Harm-Jan109,110,111; Yang, Jingyun112,113; Zhao, Wei114; Zhu, Zhihong52; Alizadeh, Behrooz Z.89,115; Amin, Najaf57; Bakshi, Andrew52; Baumeister, Sebastian E.106,116; Biino, Ginevra117; Bønnelykke, Klaus63; Boyle, Patricia A.112,118; Campbell, Harry19; Cappuccio, Francesco P.119; Davies, Gail76,120; De Neve, Jan-Emmanuel121; Deloukas, Panos122,123; Demuth, Ilja124,125; Ding, Jun96; Eibich, Peter126,127; Eisele, Lewin101; Eklund, Niina94; Evans, David M.104,128; Faul, Jessica D.129; Feitosa, Mary F.130; Forstner, Andreas J.131,132; Gandin, Ilaria73; Gunnarsson, Bjarni68; Halldórsson, Bjarni V.68,133; Harris, Tamara B.134; Heath, Andrew C.135; Hocking, Lynne J.136; Holliday, Elizabeth G.90,91; Homuth, Georg137; Horan, Michael A.138; Hottenga, Jouke-Jan62; de Jager, Philip L.111,139,140; Joshi, Peter K.19,22; Jugessur, Astanand141; Kaakinen, Marika A.142; Kähönen, Mika143,144; Kanoni, Stavroula122; Keltigangas-Järvinen, Liisa81; Kiemeney, Lambertus A. L. M.72; Kolcic, Ivana145; Koskinen, Seppo94; Kraja, Aldi T.130; Kroh, Martin126; Kutalik, Zoltan98,99,146; Latvala, Antti74; Launer, Lenore J.147; Lebreton, Maël P.60,148; Levinson, Douglas F.149; Lichtenstein, Paul46; Lichtner, Peter150; Liewald, David C. M.76,120; Loukola, LifeLines Cohort Study, Anu74; Madden, Pamela A.135; Mägi, Reedik11; Mäki-Opas, Tomi94; Marioni, Riccardo E.41,76,151; Marques-Vidal, Pedro152; Meddens, Gerardus A.153; McMahon, George104; Meisinger, Christa67; Meitinger, Thomas150; Milaneschi, Yusplitri95; Milani, Lili11; Montgomery, Grant W.154; Myhre, Ronny141; Nelson, Christopher P.75,155; Nyholt, Dale R.154,156; Ollier, William E. R.92; Palotie, Aarno16,17,111,157,158,159; Paternoster, Lavinia104; Pedersen, Nancy L.46; Petrovic, Katja E.77; Porteous, David J.38; Räikkönen, Katri81,83; Ring, Susan M.104; Robino, Antonietta160; Rostapshova, Olga7,161; Rudan, Igor19; Rustichini, Aldo162; Salomaa, Veikko94; Sanders, Alan R.163,164; Sarin, Antti-Pekka158,165; Schmidt, Helena77,166; Scott, Rodney J.91,167; Smith, Blair H.39,40; Smith, Jennifer A.89; Staessen, Jan A.168,169; Steinhagen-Thiessen, Elisabeth124; Strauch, Konstantin170,171; Terracciano, Antonio172; Tobin, Martin D.173; Ulivi, Sheila160; Vaccargiu, Simona70; Quaye, Lydia87; van Rooij, Frank J. A.57,174; Venturini, Cristina87,88; Vinkhuyzen, Anna A. E.52; Völker, Uwe137; Völzke, Henry106; Vonk, Judith M.89; Vozzi, Diego160; Waage, Johannes63,64; Ware, Erin B.114,175; Willemsen, Gonneke62; Attia, John R.90,91; Bennett, David A.112,113; Berger, Klaus107; Bertram, Lars176,177; Bisgaard, Hans63; Boomsma, Dorret I.62; Borecki, Ingrid B.130; Bültmann, Ute178; Chabris, Christopher F.50; Cucca, Francesco179; Cusi, Daniele100,180; Deary, Ian J.76,120; Dedoussis, George V.82; van Duijn, Cornelia M.57; Eriksson, Johan G.83,181; Franke, Barbara182; Franke, Lude183; Gasparini, Paolo73,160,184; Gejman, Pablo V.163,164; Gieger, Christian66; Grabe, Hans-Jörgen185,186; Gratten, Jacob52; Groenen, Patrick J. F.187; Gudnason, Vilmundur58,103; van der Harst, Pim107,183,188; Hayward, Caroline32; Hoffmann, Wolfgang106; Hyppönen, Elina189,190,191; Iacono, William G.1; Jacobsson, Bo65,141; Järvelin, Marjo-Riitta192,193,194,195; Jöckel, Karl-Heinz101; Kaprio, Jaakko74,94,158; Kardia, Sharon L. R.114; Lehtimäki, Terho196,197; Lehrer, Steven F.43,44,45; Magnusson, Patrik K. E.46; Martin, Nicholas G.198; McGue, Matt1; Metspalu, Andres11,37; Pendleton, Neil199,200; Penninx, Brenda W. J. H.95; Perola, Markus11,94; Pirastu, Nicola73; Pirastu, Mario70; Polasek, Ozren19,201; Posthuma, Danielle5,202; Power, Christine190; Province, Michael A.130; Samani, Nilesh J.75,155; Schlessinger, David96; Schmidt, Reinhold77; Sørensen, Thorkild I. A.14,104,203; Spector, Tim D.87; Stefansson, Kari68,103; Thorsteinsdottir, Unnur68,103; Thurik, A. Roy12,56,204,205; Timpson, Nicholas J.104; Tiemeier, Henning57,206,207; Tung, Joyce Y.21; Uitterlinden, André G.57,208; Vitart, Veronique32; Vollenweider, Peter152; Weir, David R.129; Wilson, James F.19,32; Wright, Alan F.32; Conley, Dalton C.42; Krueger, Robert F.1; Smith, George Davey104; Hofman, Albert57; Laibson, David I.7; Medland, Sarah E.85; Meyer, Michelle N.51; Yang, Jian10,52; Johannesson, Magnus53; Visscher, Peter M.10,52; Esko, Tõnu11; Koellinger, Philipp D.5,6,12; Cesarini, David45,49,55; Benjamin, Daniel J.9,45,54; Alver, Maris11; Bao, Yanchun18; Clark, David W.19; Day, Felix R.20; Kemper, Kathryn E.10; Kleinman, Aaron21; Langenberg, Claudia20; Trampush, Joey W.23,24; Verma, Shefali Setia25; Wu, Yang10; Lam, Max26,27; Zhao, Jing Hua20; Zheng, Zhili10,28; Boardman, Jason D.2,3,4; Freese, Jeremy29; Harris, Kathleen Mullan30,31; Herd, Pamela18,33; Kumari, Meena18; Lencz, Todd34,35,36; Luan, Jian’an20; Malhotra, Anil K.34,35,36; Ong, Ken K.20; Perry, John R. B.20; Ritchie, Marylyn D.25; Smart, Melissa C.19; Wareham, Nicholas J.20; Robinson, Matthew R.10,48; Watson, Chelsea9; Turley, Patrick16,17
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发表日期 | 2018-08 |
发表期刊 | NATURE GENETICS 影响因子和分区 |
语种 | 英语 |
原始文献类型 | Article |
其他关键词 | MAPPING CAUSAL VARIANTS ; HERITABILITY ; METAANALYSIS ; LOCI ; GWAS ; BRAIN |
摘要 | Here we conducted a large-scale genetic association analysis of educational attainment in a sample of approximately 1.1 million individuals and identify 1,271 independent genome-wide-significant SNPs. For the SNPs taken together, we found evidence of heterogeneous effects across environments. The SNPs implicate genes involved in brain-development processes and neuron-to-neuron communication. In a separate analysis of the X chromosome, we identify 10 independent genome-wide-significant SNPs and estimate a SNP heritability of around 0.3% in both men and women, consistent with partial dosage compensation. A joint (multi-phenotype) analysis of educational attainment and three related cognitive phenotypes generates polygenic scores that explain 11-13% of the variance in educational attainment and 7-10% of the variance in cognitive performance. This prediction accuracy substantially increases the utility of polygenic scores as tools in research. |
资助项目 | Social Science Genetic Association Consortium (SSGAC); Swedish Research CouncilSwedish Research CouncilEuropean Commission [2017-00641, 421-2013-1061]; Ragnar Soderberg Foundation [E9/11, E42/15]; Jan Wallander and Tom Hedelius Foundation; ERC Consolidator GrantEuropean Research Council (ERC) [647648 EdGe]; Pershing Square Fund of the Foundations of Human Behavior; Open Philanthropy Project [2016-152872]; NIA/NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute on Aging (NIA) [P01-AG005842, P01-AG005842-20S2, P30-AG012810, T32-AG000186-23, R01-AG042568]; EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENTUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) [P2CHD050924, R01HD073342, P2CHD066613, P2CHD047879] Funding Source: NIH RePORTER; NATIONAL INSTITUTE ON AGINGUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute on Aging (NIA) [R01AG015819, R01AG042568, RF1AG015819, P30AG012810, T32AG000186, P30AG010161, P01AG005842, R01AG055406] Funding Source: NIH RePORTER; BBSRCUK Research & Innovation (UKRI)Biotechnology and Biological Sciences Research Council (BBSRC) [BB/F019394/1, BB/F022441/1] Funding Source: UKRI; ESRCUK Research & Innovation (UKRI)Economic & Social Research Council (ESRC) [ES/K005774/1, ES/M008592/1, ES/S008349/1] Funding Source: UKRI; MRCUK Research & Innovation (UKRI)Medical Research Council UK (MRC) [MR/N01104X/1, MC_UU_12015/1, G0600237, G1001799, MC_UU_12015/2, MR/N01104X/2, G0100594, G0901461, 1811434] Funding Source: UKRI |
出版者 | NATURE PORTFOLIO |
出版地 | BERLIN |
ISSN | 1061-4036 |
EISSN | 1546-1718 |
卷号 | 50期号:8页码:1112-+ |
DOI | 10.1038/s41588-018-0147-3 |
页数 | 16 |
WOS类目 | Genetics & Heredity |
WOS研究方向 | Genetics & Heredity |
WOS记录号 | WOS:000440423400010 |
收录类别 | SCIE ; PUBMED ; SCOPUS |
URL | 查看原文 |
PubMed ID | 30038396 |
PMC记录号 | PMC6393768 |
SCOPUSEID | 2-s2.0-85050543338 |
ESI热点论文 | 2020-03 |
ESI高被引论文 | 2020-01 ; 2020-03 ; 2020-05 ; 2020-09 ; 2020-11 ; 2021-01 ; 2021-03 ; 2021-05 ; 2021-07 ; 2021-09 ; 2021-11 ; 2022-01 ; 2022-03 ; 2022-07 ; 2022-09 ; 2022-11 ; 2023-01 ; 2023-03 ; 2023-05 ; 2023-07 ; 2023-09 ; 2023-11 ; 2024-01 ; 2024-03 ; 2024-05 ; 2024-07 ; 2024-09 |
CNS重要论文 | CNS重要论文 |
自科自定义期刊分类 | T2(A)类 |
通讯作者地址 | [Okbay, Aysu]Department of Complex Trait Genetics,Center for Neurogenomics and Cognitive Research,Vrije Universiteit Amsterdam,Amsterdam,Netherlands |
Scopus学科分类 | Genetics |
TOP期刊 | TOP期刊 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.wmu.edu.cn/handle/3ETUA0LF/20905 |
专题 | 眼视光学院(生物医学工程学院)、附属眼视光医院 |
通讯作者 | Okbay, Aysu |
作者单位 | 1.Department of Psychology,University of Minnesota Twin Cities,Minneapolis,United States; 2.Department of Sociology,University of Colorado Boulder,Boulder,United States; 3.Institute for Behavioral Genetics,University of Colorado Boulder,Boulder,United States; 4.Institute of Behavioral Science,University of Colorado Boulder,Boulder,United States; 5.Department of Complex Trait Genetics,Center for Neurogenomics and Cognitive Research,Vrije Universiteit Amsterdam,Amsterdam,Netherlands; 6.Department of Economics,School of Business and Economics,Vrije Universiteit Amsterdam,Amsterdam,Netherlands; 7.Department of Economics,Harvard University,Cambridge,United States; 8.Department of Sociology,Harvard University,Cambridge,United States; 9.Center for Economic and Social Research,University of Southern California,Los Angeles,United States; 10.Institute for Molecular Bioscience,University of Queensland,Brisbane,Australia; 11.Estonian Genome Center,University of Tartu,Tartu,Estonia; 12.Institute for Behavior and Biology,Erasmus University Rotterdam,Rotterdam,Netherlands; 13.Center for the Advancement of Value in Musculoskeletal Care,Hospital for Special Surgery,New York,United States; 14.The Novo Nordisk Foundation Center for Basic Metabolic Research,Section of Metabolic Genetics,University of Copenhagen,Faculty of Health and Medical Sciences,Copenhagen,Denmark; 15.Statens Serum Institut,Department of Epidemiology Research,Copenhagen,Denmark; 16.Analytic and Translational Genetics Unit,Massachusetts General Hospital,Boston,United States; 17.Stanley Center for Psychiatric Research,Broad Institute of MIT and Harvard,Cambridge,United States; 18.Institute for Social and Economic Research,University of Essex,Colchester,United Kingdom; 19.Centre for Global Health Research,Usher Institute of Population Health Sciences and Informatics,University of Edinburgh,Edinburgh,United Kingdom; 20.MRC Epidemiology Unit,Institute of Metabolic Science,University of Cambridge,Cambridge,United Kingdom; 21.23andMe,Inc.,Mountain View,United States; 22.Institute of Social and Preventive Medicine,University Hospital of Lausanne,Lausanne,Switzerland; 23.BrainWorkup,LLC,Santa Monica,United States; 24.Department of Psychiatry and Behavioral Sciences,Keck School of Medicine,University of Southern California,Los Angeles,United States; 25.Department of Biomedical and Translational Informatics,Geisinger Health System,Danville,United States; 26.Institute of Mental Health,Singapore,Singapore; 27.Genome Institute,Singapore,Singapore; 28.The Eye Hospital,School of Ophthalmology and Optometry,Wenzhou Medical University,Wenzhou,China; 29.Department of Sociology,Stanford University,Stanford,United States; 30.Department of Sociology,University of North Carolina at Chapel Hill,Chapel Hill,United States; 31.Carolina Population Center,University of North Carolina at Chapel Hill,Chapel Hill,United States; 32.MRC Human Genetics Unit,Institute of Genetics and Molecular Medicine,University of Edinburgh,Edinburgh,United Kingdom; 33.La Follette School of Public Affairs,University of Wisconsin-Madison,Madison,United States; 34.Departments of Psychiatry and Molecular Medicine,Hofstra Northwell School of Medicine,Hempstead,United States; 35.Center for Psychiatric Neuroscience,Feinstein Institute for Medical Research,Manhasset,United States; 36.Psychiatry Research,The Zucker Hillside Hospital,Glen Oaks,United States; 37.Institute of Molecular and Cell Biology,University of Tartu,Tartu,Estonia; 38.Centre for Genomic and Experimental Medicine,Institute of Genetics and Molecular Medicine,University of Edinburgh,Edinburgh,United Kingdom; 39.Division of Population Health Sciences,Ninewells Hospital and Medical School,University of Dundee,Dundee,United Kingdom; 40.Medical Research Institute,University of Dundee,Dundee,United Kingdom; 41.Department of Economics,University of Toronto,Toronto,Canada; 42.Department of Sociology,Princeton University,Princeton,United States; 43.School of Policy Studies,Queen’s University,Kingston,Canada; 44.Department of Economics,New York University Shanghai,Pudong,China; 45.National Bureau of Economic Research,Cambridge,United States; 46.Department of Medical Epidemiology and Biostatistics,Karolinska Institutet,Stockholm,Sweden; 47.Department of Government,Uppsala University,Uppsala,Sweden; 48.Department of Computational Biology,University of Lausanne,Lausanne,Switzerland; 49.Department of Economics,New York University,New York,United States; 50.Autism and Developmental Medicine Institute,Geisinger Health System,Lewisburg,United States; 51.Center for Translational Bioethics and Health Care Policy,Geisinger Health System,Danville,United States; 52.Queensland Brain Institute,University of Queensland,Brisbane,Australia; 53.Department of Economics,Stockholm School of Economics,Stockholm,Sweden; 54.Department of Economics,University of Southern California,Los Angeles,United States; 55.Center for Experimental Social Science,New York University,New York,United States; 56.Department of Applied Economics,Erasmus School of Economics,Erasmus University Rotterdam,Rotterdam,Netherlands; 57.Department of Epidemiology,Erasmus Medical Center,Rotterdam,Netherlands; 58.Icelandic Heart Association,Kopavogur,Iceland; 59.Faculty of Pharmaceutical Sciences,University of Iceland,Reykjavík,Iceland; 60.Amsterdam Business School,University of Amsterdam,Amsterdam,Netherlands; 61.New York Genome Center,New York,United States; 62.Department of Biological Psychology,VU University Amsterdam,Amsterdam,Netherlands; 63.COPSAC,Copenhagen Prospective Studies on Asthma in Childhood,Herlev and Gentofte Hospital,University of Copenhagen,Copenhagen,Denmark; 64.Steno Diabetes Center,Gentofte,Denmark; 65.Department of Obstetrics and Gynecology,Institute of Clinical Sciences,Sahlgrenska Academy,Gothenburg,Sweden; 66.Research Unit of Molecular Epidemiology,Helmholtz Zentrum München,German Research Center for Environmental Health,Neuherberg,Germany; 67.Institute of Epidemiology II,Helmholtz Zentrum München,German Research Center for Environmental Health,Neuherberg,Germany; 68.deCODE Genetics/Amgen Inc.,Reykjavík,Iceland; 69.Department of Cell Biology,Erasmus Medical Center Rotterdam,Rotterdam,Netherlands; 70.Istituto di Ricerca Genetica e Biomedica U.O.S. di Sassari,National Research Council of Italy,Sassari,Italy; 71.Psychology,University of Illinois,Champaign,United States; 72.Institute for Computing and Information Sciences,Radboud University Nijmegen,Nijmegen,Netherlands; 73.Department of Medical,Surgical and Health Sciences,University of Trieste,Trieste,Italy; 74.Department of Public Health,University of Helsinki,Helsinki,Finland; 75.Department of Cardiovascular Sciences,University of Leicester,Leicester,United Kingdom; 76.Centre for Cognitive Ageing and Cognitive Epidemiology,University of Edinburgh,Edinburgh,United Kingdom; 77.Department of Neurology,General Hospital and Medical University Graz,Graz,Austria; 78.Institute for Medical Informatics,Statistics and Documentation,General Hospital and Medical University Graz,Graz,Austria; 79.Oxford Centre for Diabetes,Endocrinology and Metabolism,University of Oxford,Oxford,United Kingdom; 80.Wellcome Trust Centre for Human Genetics,University of Oxford,Oxford,United Kingdom; 81.Institute of Behavioural Sciences,University of Helsinki,Helsinki,Finland; 82.Nutrition and Dietetics,Health Science and Education,Harokopio University,Athens,Greece; 83.Folkhälsan Research Centre,Helsingfors,Finland; 84.Institute for Computing and Information Sciences,Radboud University Nijmegen,Nijmegen,Netherlands; 85.Quantitative Genetics,QIMR Berghofer Medical Research Institute,Brisbane,Australia; 86.Lifespan Psychology,Max Planck Institute for Human Development,Berlin,Germany; 87.Department of Twin Research and Genetic Epidemiology,King’s College London,London,United Kingdom; 88.NIHR Biomedical Research Centre,Guy’s and St. Thomas’ Foundation Trust,London,United Kingdom; 89.Department of Epidemiology,University Medical Center Groningen,University of Groningen,Groningen,Netherlands; 90.Public Health Stream,Hunter Medical Research Institute,New Lambton,Australia; 91.Faculty of Health and Medicine,University of Newcastle,Newcastle,Australia; 92.Centre for Integrated Genomic Medical Research,Institute of Population Health,The University of Manchester,Manchester,United Kingdom; 93.School of Psychological Sciences,The University of Manchester,Manchester,United Kingdom; 94.Department of Health,THL-National Institute for Health and Welfare,Helsinki,Finland; 95.Psychiatry,VU University Medical Center and GGZ inGeest,Amsterdam,Netherlands; 96.Laboratory of Genetics,National Institute on Aging,Baltimore,United States; 97.Research Centre of Applied and Preventive Cardiovascular Medicine,University of Turku,Turku,Finland; 98.Department of Medical Genetics,University of Lausanne,Lausanne,Switzerland; 99.Swiss Institute of Bioinformatics,Lausanne,Switzerland; 100.Department Of Health Sciences,University of Milan,Milan,Italy; 101.Institute for Medical Informatics,Biometry and Epidemiology,University Hospital of Essen,Essen,Germany; 102.Division of Cancer Epidemiology and Genetics,National Cancer Institute,Bethesda,United States; 103.Faculty of Medicine,University of Iceland,Reykjavík,Iceland; 104.MRC Integrative Epidemiology Unit,University of Bristol,Bristol,United Kingdom; 105.School of Oral and Dental Sciences,University of Bristol,Bristol,United Kingdom; 106.Institute for Community Medicine,University Medicine Greifswald,Greifswald,Germany; 107.Department of Cardiology,University Medical Center Groningen,University of Groningen,Groningen,Netherlands; 108.Institute of Epidemiology and Social Medicine,University of Münster,Münster,Germany; 109.Divisions of Genetics and Rheumatology,Department of Medicine,Brigham and Women’s Hospital,Harvard Medical School,Boston,United States; 110.Partners Center for Personalized Genetic Medicine,Boston,United States; 111.Program in Medical and Population Genetics,Broad Institute of MIT and Harvard,Cambridge,United States; 112.Rush Alzheimer’s Disease Center,Rush University Medical Center,Chicago,United States; 113.Department of Neurological Sciences,Rush University Medical Center,Chicago,United States; 114.Department of Epidemiology,University of Michigan,Ann Arbor,United States; 115.Department of Gastroenterology and Hepatology,University Medical Center Groningen,University of Groningen,Groningen,Netherlands; 116.Institute of Epidemiology and Preventive Medicine,University of Regensburg,Regensburg,Germany; 117.Institute of Molecular Genetics,National Research Council of Italy,Pavia,Italy; 118.Department of Behavioral Sciences,Rush University Medical Center,Chicago,United States; 119.Warwick Medical School,University of Warwick,Coventry,United Kingdom; 120.Department of Psychology,University of Edinburgh,Edinburgh,United Kingdom; 121.Saïd Business School,University of Oxford,Oxford,United Kingdom; 122.William Harvey Research Institute,Barts and The London School of Medicine and Dentistry,Queen Mary University of London,London,United Kingdom; 123.Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD),King Abdulaziz University,Jeddah,Saudi Arabia; 124.The Berlin Aging Study II; Research Group on Geriatrics,Charité-Universitätsmedizin Berlin,Berlin,Germany; 125.Institute of Medical and Human Genetics,Charité-Universitätsmedizin Berlin,Berlin,Germany; 126.German Socio-Economic Panel Study,DIW Berlin,Berlin,Germany; 127.Health Economics Research Centre,Nuffield Department of Population Health,University of Oxford,Oxford,United Kingdom; 128.The University of Queensland Diamantina Institute,The Translational Research Institute,Brisbane,Australia; 129.Survey Research Center,Institute for Social Research,University of Michigan,Ann Arbor,United States; 130.Department of Genetics,Division of Statistical Genomics,Washington University School of Medicine,St Louis,United States; 131.Institute of Human Genetics,University of Bonn,Bonn,Germany; 132.Department of Genomics,Life and Brain Center,University of Bonn,Bonn,Germany; 133.Institute of Biomedical and Neural Engineering,School of Science and Engineering,Reykjavík University,Reykjavík,Iceland; 134.Laboratory of Epidemiology,Demography,National Institute on Aging,National Institutes of Health,Bethesda,United States; 135.Department of Psychiatry,Washington University School of Medicine,St Louis,United States; 136.Division of Applied Health Sciences,University of Aberdeen,Aberdeen,United Kingdom; 137.Interfaculty Institute for Genetics and Functional Genomics,University Medicine Greifswald,Greifswald,Germany; 138.Manchester Medical School,The University of Manchester,Manchester,United Kingdom; 139.Program in Translational NeuroPsychiatric Genomics,Departments of Neurology and Psychiatry,Brigham and Women’s Hospital,Boston,United States; 140.Harvard Medical School,Boston,United States; 141.Department of Genes and Environment,Norwegian Institute of Public Health,Oslo,Norway; 142.Department of Genomics of Common Disease,Imperial College London,London,United Kingdom; 143.Department of Clinical Physiology,Tampere University Hospital,Tampere,Finland; 144.Department of Clinical Physiology,University of Tampere,School of Medicine,Tampere,Finland; 145.Public Health,Medical School,University of Split,Split,Croatia; 146.Institute of Social and Preventive Medicine,Lausanne University Hospital (CHUV),Lausanne,Switzerland; 147.Neuroepidemiology Section,National Institute on Aging,National Institutes of Health,Bethesda,United States; 148.Amsterdam Brain and Cognition Center,University of Amsterdam,Amsterdam,Netherlands; 149.Department of Psychiatry and Behavioral Sciences,Stanford University,Stanford,United States; 150.Institute of Human Genetics,Helmholtz Zentrum München,German Research Center for Environmental Health,Neuherberg,Germany; 151.Medical Genetics Section,Centre for Genomic and Experimental Medicine,Institute of Genetics and Molecular Medicine,University of Edinburgh,Edinburgh,United Kingdom; 152.Department of Internal Medicine,Lausanne University Hospital (CHUV),Lausanne,Switzerland; 153.Tema BV,Hoofddorp,Netherlands; 154.Molecular Epidemiology,QIMR Berghofer Medical Research Institute,Brisbane,Australia; 155.NIHR Leicester Cardiovascular Biomedical Research Unit,Glenfield Hospital,Leicester,United Kingdom; 156.Institute of Health and Biomedical Innovation,Queensland Institute of Technology,Brisbane,Australia; 157.Psychiatric and Neurodevelopmental Genetics Unit,Department of Psychiatry,Massachusetts General Hospital,Boston,United States; 158.Institute for Molecular Medicine Finland (FIMM),University of Helsinki,Helsinki,Finland; 159.Department of Neurology,Massachusetts General Hospital,Boston,United States; 160.Medical Genetics,Institute for Maternal and Child Health IRCCS “Burlo Garofolo”,Trieste,Italy; 161.Social Impact,Arlington,United States; 162.Department of Economics,University of Minnesota Twin Cities,Minneapolis,United States; 163.Department of Psychiatry and Behavioral Sciences,NorthShore University HealthSystem,Evanston,United States; 164.Department of Psychiatry and Behavioral Neuroscience,University of Chicago,Chicago,United States; 165.Public Health Genomics Unit,National Institute for Health and Welfare,Helsinki,Finland; 166.Research Unit for Genetic Epidemiology,Institute of Molecular Biology and Biochemistry,Center of Molecular Medicine,General Hospital and Medical University,Graz,Austria; 167.Information Based Medicine Stream,Hunter Medical Research Institute,New Lambton,Australia; 168.Research Unit Hypertension and Cardiovascular Epidemiology,Department of Cardiovascular Science,University of Leuven,Leuven,Belgium; 169.R&D VitaK Group,Maastricht University,Maastricht,Netherlands; 170.Institute of Genetic Epidemiology,Helmholtz Zentrum München,German Research Center for Environmental Health,Neuherberg,Germany; 171.Institute of Medical Informatics,Biometry and Epidemiology,Chair of Genetic Epidemiology,Ludwig Maximilians-Universität,Munich,Germany; 172.Department of Geriatrics,Florida State University College of Medicine,Tallahassee,United States; 173.Department of Health Sciences and Genetics,University of Leicester,Leicester,United Kingdom; 174.Department of Internal Medicine,Erasmus Medical Center,Rotterdam,Netherlands; 175.Research Center for Group Dynamics,Institute for Social Research,University of Michigan,Ann Arbor,United States; 176.Platform for Genome Analytics,Institutes of Neurogenetics and Integrative and Experimental Genomics,University of Lübeck,Lübeck,Germany; 177.Neuroepidemiology and Ageing Research Unit,School of Public Health,Faculty of Medicine,Imperial College London,London,United Kingdom; 178.Department of Health Sciences,Community and Occupational Medicine,University Medical Center Groningen,University of Groningen,Groningen,Netherlands; 179.Istituto di Ricerca Genetica e Biomedica (IRGB),Consiglio Nazionale delle Ricerche,c/o Cittadella Universitaria di Monserrato,Monserrato,Cagliari,Italy; 180.Institute of Biomedical Technologies,Italian National Research Council,Segrate,Italy; 181.Department of General Practice and Primary Health Care,University of Helsinki,Helsinki,Finland; 182.Departments of Human Genetics and Psychiatry,Donders Centre for Neuroscience,Nijmegen,Netherlands; 183.Department of Genetics,University Medical Center Groningen,University of Groningen,Groningen,Netherlands; 184.Sidra,Experimental Genetics Division,Sidra,Qatar; 185.Department of Psychiatry and Psychotherapy,University Medicine Greifswald,Greifswald,Germany; 186.Department of Psychiatry and Psychotherapy,HELIOS-Hospital Stralsund,Stralsund,Germany; 187.Econometric Institute,Erasmus School of Economics,Erasmus University Rotterdam,Rotterdam,Netherlands; 188.Durrer Center for Cardiogenetic Research,ICIN-Netherlands Heart Institute,Utrecht,Netherlands; 189.Centre for Population Health Research,School of Health Sciences and Sansom Institute,University of South Australia,Adelaide,Australia; 190.South Australian Health and Medical Research Institute,Adelaide,Australia; 191.Population,Policy and Practice,UCL Institute of Child Health,University College London,London,United Kingdom; 192.Department of Epidemiology and Biostatistics,MRC-PHE Centre for Environment and Health,School of Public Health,Imperial College London,London,United Kingdom; 193.Center for Life Course Epidemiology,Faculty of Medicine,University of Oulu,Oulu,Finland; 194.Unit of Primary Care,Oulu University Hospital,Oulu,Finland; 195.Biocenter Oulu,University of Oulu,Oulu,Finland; 196.Fimlab Laboratories,Tampere,Finland; 197.Department of Clinical Chemistry,University of Tampere,School of Medicine,Tampere,Finland; 198.Genetic Epidemiology,QIMR Berghofer Medical Research Institute,Brisbane,Australia; 199.Centre for Clinical and Cognitive Neuroscience,Institute Brain Behaviour and Mental Health,Salford Royal Hospital,Manchester,United Kingdom; 200.Manchester Institute Collaborative Research in Ageing,University of Manchester,Manchester,United Kingdom; 201.Faculty of Medicine,University of Split,Split,Croatia; 202.Department of Clinical Genetics,VU Medical Centre,Amsterdam,Netherlands; 203.Institute of Preventive Medicine,Bispebjerg and Frederiksberg Hospitals,The Capital Region,Frederiksberg,Denmark; 204.Montpellier Business School,Montpellier,France; 205.Panteia,Zoetermeer,Netherlands; 206.Department of Psychiatry,Erasmus Medical Center,Rotterdam,Netherlands; 207.Department of Child and Adolescent Psychiatry,Erasmus Medical Center,Rotterdam,Netherlands; 208.Department of Internal Medicine,Erasmus Medical Center,Rotterdam,Netherlands |
推荐引用方式 GB/T 7714 | Lee, James J.,Wedow, Robbee,Okbay, Aysu,et al. Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals[J]. NATURE GENETICS,2018,50(8):1112-+. |
APA | Lee, James J.., Wedow, Robbee., Okbay, Aysu., Kong, Edward., Maghzian, Omeed., ... & Turley, Patrick. (2018). Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. NATURE GENETICS, 50(8), 1112-+. |
MLA | Lee, James J.,et al."Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals".NATURE GENETICS 50.8(2018):1112-+. |
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