科研成果详情

题名Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals
作者
Lee, James J.1; Wedow, Robbee2,3,4; Okbay, Aysu5,6; Kong, Edward7; Maghzian, Omeed7; Zacher, Meghan8; Tuan Anh Nguyen-Viet9; Bowers, Peter7; Sidorenko, Julia10,11; Linner, Richard Karlsson5,6; Fontana, Mark Alan13; Kundu, Tushar9; Lee, Chanwook7; Li, Hui7; Li, Ruoxi9; Royer, Rebecca9; Timshel, Pascal N.14,15; Walters, Raymond K.16,17; Willoughby, Emily A.1; Yengo, Loic10; Alver, Maris11; Bao, Yanchun18; Clark, David W.19; Day, Felix R.20; Furlotte, Nicholas A.21; Joshi, Peter K.19,22; Kemper, Kathryn E.10; Kleinman, Aaron21; Langenberg, Claudia20; Magi, Reedik11; Trampush, Joey W.23,24; Verma, Shefali Setia25; Wu, Yang10; Lam, Max26,27; Zhao, Jing Hua20; Zheng, Zhili10,28; Boardman, Jason D.2,3,4; Campbell, Harry19; Freese, Jeremy29; Harris, Kathleen Mullan30,31; Hayward, Caroline32; Herd, Pamela18,33; Kumari, Meena18; Lencz, Todd34,35,36,37; Luan, Jian'an20; Malhotra, Anil K.34,35,36,37; Metspalu, Andres11,38; Milani, Lili11; Ong, Ken K.20; Perry, John R. B.20; Porteous, David J.39; Ritchie, Marylyn D.; Smart, Melissa C.19; Smith, Blair H.40,41,42; Tung, Joyce Y.21; Wareham, Nicholas J.20; Wilson, James F.19,32; Beauchamp, Jonathan P.43; Conley, Dalton C.44; Esko, Tonu11; Lehrer, Steven F.45,46,47; Magnusson, Patrik K. E.48; Oskarsson, Sven49; Pers, Tune H.14,15; Robinson, Matthew R.50; Thom, Kevin51; Watson, Chelsea9; Chabris, Christopher F.52; Meyer, Michelle N.53; Laibson, David I.7; Yang, Jian10,54; Johannesson, Magnus55; Koellinger, Philipp D.5,6,12; Turley, Patrick16,17; Visscher, Peter M.10,54; Benjamin, Daniel J.9,47,56; Cesarini, David57
发表期刊NATURE GENETICS   影响因子和分区
语种英语
原始文献类型Article
其他关键词MAPPING CAUSAL VARIANTS ; HERITABILITY ; METAANALYSIS ; LOCI ; GWAS ; BRAIN
摘要Here we conducted a large-scale genetic association analysis of educational attainment in a sample of approximately 1.1 million individuals and identify 1,271 independent genome-wide-significant SNPs. For the SNPs taken together, we found evidence of heterogeneous effects across environments. The SNPs implicate genes involved in brain-development processes and neuron-to-neuron communication. In a separate analysis of the X chromosome, we identify 10 independent genome-wide-significant SNPs and estimate a SNP heritability of around 0.3% in both men and women, consistent with partial dosage compensation. A joint (multi-phenotype) analysis of educational attainment and three related cognitive phenotypes generates polygenic scores that explain 11-13% of the variance in educational attainment and 7-10% of the variance in cognitive performance. This prediction accuracy substantially increases the utility of polygenic scores as tools in research.
资助项目Social Science Genetic Association Consortium (SSGAC); Swedish Research CouncilSwedish Research CouncilEuropean Commission [2017-00641, 421-2013-1061]; Ragnar Soderberg Foundation [E9/11, E42/15]; Jan Wallander and Tom Hedelius Foundation; ERC Consolidator GrantEuropean Research Council (ERC) [647648 EdGe]; Pershing Square Fund of the Foundations of Human Behavior; Open Philanthropy Project [2016-152872]; NIA/NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute on Aging (NIA) [P01-AG005842, P01-AG005842-20S2, P30-AG012810, T32-AG000186-23, R01-AG042568]; EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENTUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) [P2CHD050924, R01HD073342, P2CHD066613, P2CHD047879] Funding Source: NIH RePORTER; NATIONAL INSTITUTE ON AGINGUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute on Aging (NIA) [R01AG015819, R01AG042568, RF1AG015819, P30AG012810, T32AG000186, P30AG010161, P01AG005842, R01AG055406] Funding Source: NIH RePORTER; BBSRCUK Research & Innovation (UKRI)Biotechnology and Biological Sciences Research Council (BBSRC) [BB/F019394/1, BB/F022441/1] Funding Source: UKRI; ESRCUK Research & Innovation (UKRI)Economic & Social Research Council (ESRC) [ES/K005774/1, ES/M008592/1, ES/S008349/1] Funding Source: UKRI; MRCUK Research & Innovation (UKRI)Medical Research Council UK (MRC) [MR/N01104X/1, MC_UU_12015/1, G0600237, G1001799, MC_UU_12015/2, MR/N01104X/2, G0100594, G0901461, 1811434] Funding Source: UKRI
出版者NATURE PORTFOLIO
出版地BERLIN
ISSN1061-4036
EISSN1546-1718
卷号50期号:8页码:1112-+
DOI10.1038/s41588-018-0147-3
WOS类目Genetics & Heredity
WOS研究方向Genetics & Heredity
WOS记录号WOS:000440423400010
收录类别SCIE ; PUBMED ; SCOPUS
发表日期2018-08
URL查看原文
Pubmed记录号30038396
PMC记录号PMC6393768
Scopus记录号2-s2.0-85050543338
ESI热点论文2020-03
ESI高被引论文2020-01 ; 2020-03 ; 2020-05 ; 2020-09 ; 2020-11 ; 2021-01 ; 2021-03 ; 2021-05 ; 2021-07 ; 2021-09 ; 2021-11 ; 2022-01 ; 2022-03 ; 2022-07 ; 2022-09 ; 2022-11 ; 2023-01 ; 2023-03 ; 2023-05 ; 2023-07 ; 2023-09 ; 2023-11 ; 2024-01 ; 2024-03 ; 2024-05
CNS重要论文CNS重要论文
自科自定义期刊分类T2(A)类
引用统计
被引频次:855[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符https://kms.wmu.edu.cn/handle/3ETUA0LF/20905
专题眼视光学院(生物医学工程学院)、附属眼视光医院
通讯作者Okbay, Aysu
作者单位
1.Univ Minnesota Twin Cities, Dept Psychol, Minneapolis, MN USA;
2.Univ Colorado, Dept Sociol, Boulder, CO 80309 USA;
3.Univ Colorado, Inst Behav Genet, Boulder, CO 80309 USA;
4.Univ Colorado, Inst Behav Sci, Boulder, CO 80309 USA;
5.Vrije Univ Amsterdam, Dept Complex Trait Genet, Ctr Neurogen & Cognit Res, Amsterdam, Netherlands;
6.Vrije Univ Amsterdam, Sch Business & Econ, Dept Econ, Amsterdam, Netherlands;
7.Harvard Univ, Dept Econ, Cambridge, MA 02138 USA;
8.Harvard Univ, Dept Sociol, Cambridge, MA 02138 USA;
9.Univ Southern Calif, Ctr Econ & Social Res, Los Angeles, CA USA;
10.Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia;
11.Univ Tartu, Estonian Genome Ctr, Tartu, Estonia;
12.Erasmus Univ, Inst Behav & Biol, Rotterdam, Netherlands;
13.Hosp Special Surg, Ctr Adv Value Musculoskeletal Care, 535 E 70th St, New York, NY 10021 USA;
14.Univ Copenhagen, Fac Hlth & Med Sci, Sect Metab Genet, Novo Nordisk Fdn Ctr Basic Metab Res, Copenhagen, Denmark;
15.Statens Serum Inst, Dept Epidemiol Res, Copenhagen, Denmark;
16.Massachusetts Gen Hosp, Analyt & Translat Genet Unit, Boston, MA 02114 USA;
17.MIT & Harvard, Stanley Ctr Psychiat Res, Broad Inst, Cambridge, MA USA;
18.Univ Essex, Inst Social & Econ Res, Colchester, Essex, England;
19.Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Ctr Global Hlth Res, Edinburgh, Midlothian, Scotland;
20.Univ Cambridge, Inst Metab Sci, MRC Epidemiol Unit, Cambridge, England;
21.23&Me Inc, Mountain View, CA USA;
22.Univ Lausanne Hosp, Inst Social & Prevent Med, Lausanne, Switzerland;
23.BrainWorkup LLC, Santa Monica, CA USA;
24.Univ Southern Calif, Keck Sch Med, Dept Psychiat & Behav Sci, Los Angeles, CA USA;
25.Geisinger Hlth Syst, Dept Biomed & Translat Informat, Danville, PA USA;
26.Inst Mental Hlth, Singapore, Singapore;
27.Genome Inst, Singapore, Singapore;
28.Wenzhou Med Univ, Sch Ophthalmol & Optometry, Eye Hosp, Wenzhou, Peoples R China;
29.Stanford Univ, Dept Sociol, Stanford, CA 94305 USA;
30.Univ North Carolina Chapel Hill, Dept Sociol, Chapel Hill, NC USA;
31.Univ North Carolina Chapel Hill, Carolina Populat Ctr, Chapel Hill, NC USA;
32.Univ Edinburgh, Inst Genet & Mol Med, MRC Human Genet Unit, Edinburgh, Midlothian, Scotland;
33.Univ Wisconsin, La Follette Sch Publ Affairs, Madison, WI USA;
34.Hofstra Northwell Sch Med, Dept Psychiat, Hempstead, NY USA;
35.Hofstra Northwell Sch Med, Dept Mol Med, Hempstead, NY USA;
36.Feinstein Inst Med Res, Ctr Psychiat Neurosci, Manhasset, NY USA;
37.Zucker Hillside Hosp, Psychiat Res, Glen Oaks, CA USA;
38.Univ Tartu, Inst Mol & Cell Biol, Tartu, Estonia;
39.Univ Edinburgh, Inst Genet & Mol Med, Ctr Genom & Expt Med, Edinburgh, Midlothian, Scotland;
40.Univ Dundee, Div Populat Hlth Sci, Ninewells Hosp, Dundee, Scotland;
41.Univ Dundee, Med Sch, Dundee, Scotland;
42.Univ Dundee, Med Res Inst, Dundee, Scotland;
43.Univ Toronto, Dept Econ, Toronto, ON, Canada;
44.Princeton Univ, Dept Sociol, Princeton, NJ 08544 USA;
45.Queens Univ, Sch Policy Studies, Kingston, ON, Canada;
46.New York Univ Shanghai, Dept Econ, Shanghai, Peoples R China;
47.Natl Bur Econ Res, Cambridge, MA 02138 USA;
48.Karolinska Inst, Depnt Med Epidemiol & Biostat, Stockholm, Sweden;
49.Uppsala Univ, Dept Govt, Uppsala, Sweden;
50.Univ Lausanne, Dept Computat Biol, Lausanne, Switzerland;
51.NYU, Dept Econ, New York, NY 10003 USA;
52.Geisinger Hlth Syst, Autism & Dev Med Inst, Lewisburg, PA USA;
53.Geisinger Hlth Syst, Ctr Translat Bioeth & Hlth Care Policy, Danville, PA USA;
54.Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia;
55.Stockholm Sch Econ, Dept Econ, Stockholm, Sweden;
56.Univ Southern Calif, Dept Econ, Los Angeles, CA USA;
57.NYU, Ctr Expt Social Sci, New York, NY USA
推荐引用方式
GB/T 7714
Lee, James J.,Wedow, Robbee,Okbay, Aysu,et al. Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals[J]. NATURE GENETICS,2018,50(8):1112-+.
APA Lee, James J.., Wedow, Robbee., Okbay, Aysu., Kong, Edward., Maghzian, Omeed., ... & Cesarini, David. (2018). Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. NATURE GENETICS, 50(8), 1112-+.
MLA Lee, James J.,et al."Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals".NATURE GENETICS 50.8(2018):1112-+.

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