题名 | Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals |
作者 | Lee, James J.1; Wedow, Robbee2,3,4; Okbay, Aysu5,6; Kong, Edward7; Maghzian, Omeed7; Zacher, Meghan8; Tuan Anh Nguyen-Viet9; Bowers, Peter7; Sidorenko, Julia10,11; Linner, Richard Karlsson5,6; Fontana, Mark Alan13; Kundu, Tushar9; Lee, Chanwook7; Li, Hui7; Li, Ruoxi9; Royer, Rebecca9; Timshel, Pascal N.14,15; Walters, Raymond K.16,17; Willoughby, Emily A.1; Yengo, Loic10; Alver, Maris11; Bao, Yanchun18; Clark, David W.19; Day, Felix R.20; Furlotte, Nicholas A.21; Joshi, Peter K.19,22; Kemper, Kathryn E.10; Kleinman, Aaron21; Langenberg, Claudia20; Magi, Reedik11; Trampush, Joey W.23,24; Verma, Shefali Setia25; Wu, Yang10; Lam, Max26,27; Zhao, Jing Hua20; Zheng, Zhili10,28; Boardman, Jason D.2,3,4; Campbell, Harry19; Freese, Jeremy29; Harris, Kathleen Mullan30,31; Hayward, Caroline32; Herd, Pamela18,33; Kumari, Meena18; Lencz, Todd34,35,36,37; Luan, Jian'an20; Malhotra, Anil K.34,35,36,37; Metspalu, Andres11,38; Milani, Lili11; Ong, Ken K.20; Perry, John R. B.20; Porteous, David J.39; Ritchie, Marylyn D.; Smart, Melissa C.19; Smith, Blair H.40,41,42; Tung, Joyce Y.21; Wareham, Nicholas J.20; Wilson, James F.19,32; Beauchamp, Jonathan P.43; Conley, Dalton C.44; Esko, Tonu11; Lehrer, Steven F.45,46,47; Magnusson, Patrik K. E.48; Oskarsson, Sven49; Pers, Tune H.14,15; Robinson, Matthew R.50; Thom, Kevin51; Watson, Chelsea9; Chabris, Christopher F.52; Meyer, Michelle N.53; Laibson, David I.7; Yang, Jian10,54; Johannesson, Magnus55; Koellinger, Philipp D.5,6,12; Turley, Patrick16,17; Visscher, Peter M.10,54; Benjamin, Daniel J.9,47,56; Cesarini, David57
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发表期刊 | NATURE GENETICS 影响因子和分区 |
语种 | 英语 |
原始文献类型 | Article |
其他关键词 | MAPPING CAUSAL VARIANTS ; HERITABILITY ; METAANALYSIS ; LOCI ; GWAS ; BRAIN |
摘要 | Here we conducted a large-scale genetic association analysis of educational attainment in a sample of approximately 1.1 million individuals and identify 1,271 independent genome-wide-significant SNPs. For the SNPs taken together, we found evidence of heterogeneous effects across environments. The SNPs implicate genes involved in brain-development processes and neuron-to-neuron communication. In a separate analysis of the X chromosome, we identify 10 independent genome-wide-significant SNPs and estimate a SNP heritability of around 0.3% in both men and women, consistent with partial dosage compensation. A joint (multi-phenotype) analysis of educational attainment and three related cognitive phenotypes generates polygenic scores that explain 11-13% of the variance in educational attainment and 7-10% of the variance in cognitive performance. This prediction accuracy substantially increases the utility of polygenic scores as tools in research. |
资助项目 | Social Science Genetic Association Consortium (SSGAC); Swedish Research CouncilSwedish Research CouncilEuropean Commission [2017-00641, 421-2013-1061]; Ragnar Soderberg Foundation [E9/11, E42/15]; Jan Wallander and Tom Hedelius Foundation; ERC Consolidator GrantEuropean Research Council (ERC) [647648 EdGe]; Pershing Square Fund of the Foundations of Human Behavior; Open Philanthropy Project [2016-152872]; NIA/NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute on Aging (NIA) [P01-AG005842, P01-AG005842-20S2, P30-AG012810, T32-AG000186-23, R01-AG042568]; EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENTUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) [P2CHD050924, R01HD073342, P2CHD066613, P2CHD047879] Funding Source: NIH RePORTER; NATIONAL INSTITUTE ON AGINGUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute on Aging (NIA) [R01AG015819, R01AG042568, RF1AG015819, P30AG012810, T32AG000186, P30AG010161, P01AG005842, R01AG055406] Funding Source: NIH RePORTER; BBSRCUK Research & Innovation (UKRI)Biotechnology and Biological Sciences Research Council (BBSRC) [BB/F019394/1, BB/F022441/1] Funding Source: UKRI; ESRCUK Research & Innovation (UKRI)Economic & Social Research Council (ESRC) [ES/K005774/1, ES/M008592/1, ES/S008349/1] Funding Source: UKRI; MRCUK Research & Innovation (UKRI)Medical Research Council UK (MRC) [MR/N01104X/1, MC_UU_12015/1, G0600237, G1001799, MC_UU_12015/2, MR/N01104X/2, G0100594, G0901461, 1811434] Funding Source: UKRI |
出版者 | NATURE PORTFOLIO |
出版地 | BERLIN |
ISSN | 1061-4036 |
EISSN | 1546-1718 |
卷号 | 50期号:8页码:1112-+ |
DOI | 10.1038/s41588-018-0147-3 |
WOS类目 | Genetics & Heredity |
WOS研究方向 | Genetics & Heredity |
WOS记录号 | WOS:000440423400010 |
收录类别 | SCIE ; PUBMED ; SCOPUS |
发表日期 | 2018-08 |
URL | 查看原文 |
Pubmed记录号 | 30038396 |
PMC记录号 | PMC6393768 |
Scopus记录号 | 2-s2.0-85050543338 |
ESI热点论文 | 2020-03 |
ESI高被引论文 | 2020-01 ; 2020-03 ; 2020-05 ; 2020-09 ; 2020-11 ; 2021-01 ; 2021-03 ; 2021-05 ; 2021-07 ; 2021-09 ; 2021-11 ; 2022-01 ; 2022-03 ; 2022-07 ; 2022-09 ; 2022-11 ; 2023-01 ; 2023-03 ; 2023-05 ; 2023-07 ; 2023-09 ; 2023-11 ; 2024-01 ; 2024-03 ; 2024-05 |
CNS重要论文 | CNS重要论文 |
自科自定义期刊分类 | T2(A)类 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.wmu.edu.cn/handle/3ETUA0LF/20905 |
专题 | 眼视光学院(生物医学工程学院)、附属眼视光医院 |
通讯作者 | Okbay, Aysu |
作者单位 | 1.Univ Minnesota Twin Cities, Dept Psychol, Minneapolis, MN USA; 2.Univ Colorado, Dept Sociol, Boulder, CO 80309 USA; 3.Univ Colorado, Inst Behav Genet, Boulder, CO 80309 USA; 4.Univ Colorado, Inst Behav Sci, Boulder, CO 80309 USA; 5.Vrije Univ Amsterdam, Dept Complex Trait Genet, Ctr Neurogen & Cognit Res, Amsterdam, Netherlands; 6.Vrije Univ Amsterdam, Sch Business & Econ, Dept Econ, Amsterdam, Netherlands; 7.Harvard Univ, Dept Econ, Cambridge, MA 02138 USA; 8.Harvard Univ, Dept Sociol, Cambridge, MA 02138 USA; 9.Univ Southern Calif, Ctr Econ & Social Res, Los Angeles, CA USA; 10.Univ Queensland, Inst Mol Biosci, Brisbane, Qld, Australia; 11.Univ Tartu, Estonian Genome Ctr, Tartu, Estonia; 12.Erasmus Univ, Inst Behav & Biol, Rotterdam, Netherlands; 13.Hosp Special Surg, Ctr Adv Value Musculoskeletal Care, 535 E 70th St, New York, NY 10021 USA; 14.Univ Copenhagen, Fac Hlth & Med Sci, Sect Metab Genet, Novo Nordisk Fdn Ctr Basic Metab Res, Copenhagen, Denmark; 15.Statens Serum Inst, Dept Epidemiol Res, Copenhagen, Denmark; 16.Massachusetts Gen Hosp, Analyt & Translat Genet Unit, Boston, MA 02114 USA; 17.MIT & Harvard, Stanley Ctr Psychiat Res, Broad Inst, Cambridge, MA USA; 18.Univ Essex, Inst Social & Econ Res, Colchester, Essex, England; 19.Univ Edinburgh, Usher Inst Populat Hlth Sci & Informat, Ctr Global Hlth Res, Edinburgh, Midlothian, Scotland; 20.Univ Cambridge, Inst Metab Sci, MRC Epidemiol Unit, Cambridge, England; 21.23&Me Inc, Mountain View, CA USA; 22.Univ Lausanne Hosp, Inst Social & Prevent Med, Lausanne, Switzerland; 23.BrainWorkup LLC, Santa Monica, CA USA; 24.Univ Southern Calif, Keck Sch Med, Dept Psychiat & Behav Sci, Los Angeles, CA USA; 25.Geisinger Hlth Syst, Dept Biomed & Translat Informat, Danville, PA USA; 26.Inst Mental Hlth, Singapore, Singapore; 27.Genome Inst, Singapore, Singapore; 28.Wenzhou Med Univ, Sch Ophthalmol & Optometry, Eye Hosp, Wenzhou, Peoples R China; 29.Stanford Univ, Dept Sociol, Stanford, CA 94305 USA; 30.Univ North Carolina Chapel Hill, Dept Sociol, Chapel Hill, NC USA; 31.Univ North Carolina Chapel Hill, Carolina Populat Ctr, Chapel Hill, NC USA; 32.Univ Edinburgh, Inst Genet & Mol Med, MRC Human Genet Unit, Edinburgh, Midlothian, Scotland; 33.Univ Wisconsin, La Follette Sch Publ Affairs, Madison, WI USA; 34.Hofstra Northwell Sch Med, Dept Psychiat, Hempstead, NY USA; 35.Hofstra Northwell Sch Med, Dept Mol Med, Hempstead, NY USA; 36.Feinstein Inst Med Res, Ctr Psychiat Neurosci, Manhasset, NY USA; 37.Zucker Hillside Hosp, Psychiat Res, Glen Oaks, CA USA; 38.Univ Tartu, Inst Mol & Cell Biol, Tartu, Estonia; 39.Univ Edinburgh, Inst Genet & Mol Med, Ctr Genom & Expt Med, Edinburgh, Midlothian, Scotland; 40.Univ Dundee, Div Populat Hlth Sci, Ninewells Hosp, Dundee, Scotland; 41.Univ Dundee, Med Sch, Dundee, Scotland; 42.Univ Dundee, Med Res Inst, Dundee, Scotland; 43.Univ Toronto, Dept Econ, Toronto, ON, Canada; 44.Princeton Univ, Dept Sociol, Princeton, NJ 08544 USA; 45.Queens Univ, Sch Policy Studies, Kingston, ON, Canada; 46.New York Univ Shanghai, Dept Econ, Shanghai, Peoples R China; 47.Natl Bur Econ Res, Cambridge, MA 02138 USA; 48.Karolinska Inst, Depnt Med Epidemiol & Biostat, Stockholm, Sweden; 49.Uppsala Univ, Dept Govt, Uppsala, Sweden; 50.Univ Lausanne, Dept Computat Biol, Lausanne, Switzerland; 51.NYU, Dept Econ, New York, NY 10003 USA; 52.Geisinger Hlth Syst, Autism & Dev Med Inst, Lewisburg, PA USA; 53.Geisinger Hlth Syst, Ctr Translat Bioeth & Hlth Care Policy, Danville, PA USA; 54.Univ Queensland, Queensland Brain Inst, Brisbane, Qld, Australia; 55.Stockholm Sch Econ, Dept Econ, Stockholm, Sweden; 56.Univ Southern Calif, Dept Econ, Los Angeles, CA USA; 57.NYU, Ctr Expt Social Sci, New York, NY USA |
推荐引用方式 GB/T 7714 | Lee, James J.,Wedow, Robbee,Okbay, Aysu,et al. Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals[J]. NATURE GENETICS,2018,50(8):1112-+. |
APA | Lee, James J.., Wedow, Robbee., Okbay, Aysu., Kong, Edward., Maghzian, Omeed., ... & Cesarini, David. (2018). Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals. NATURE GENETICS, 50(8), 1112-+. |
MLA | Lee, James J.,et al."Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals".NATURE GENETICS 50.8(2018):1112-+. |
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