科研成果详情

题名Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome
作者
Shi, Yongyong1,2,3; Zhao, Han4,5,6,7; Shi, Yuhua4,5,6,7; Cao, Yunxia8; Yang, Dongzi9; Li, Zhiqiang1,2,3; Zhang, Bo10; Liang, Xiaoyan11; Li, Tao4; Chen, Jianhua1,12; Shen, Jiawei1; Zhao, Junzhao13; You, Li4,5,6,7; Gao, Xuan4,5,6,7; Zhu, Dongyi14; Zhao, Xiaoming15; Yan, Ying16; Qin, Yingying4,5,6,7; Li, Wenjin1; Yan, Junhao4,5,6,7; Wang, Qingzhong1; Zhao, Junli17; Geng, Ling4,5,6,7; Ma, Jinlong4,5,6,7; Zhao, Yueran4,5,6,7; He, Guang1; Zhang, Aiping1; Zou, Shuhua18; Yang, Aijun19; Liu, Jiayin20; Li, Weidong1; Li, Baojie1; Wan, Chunling1; Qin, Ying21; Shi, Juanzi22; Yang, Jing23; Jiang, Hong24; Xu, Jin-E25; Qi, Xiujuan25; Sun, Yun15; Zhang, Yajie26; Hao, Cuifang27; Ju, Xiuqing28; Zhao, Dongni29; Ren, Chun-E30; Li, Xiuqing31; Zhang, Wei32; Zhang, Yiwen33; Zhang, Jiangtao4,5; Wu, Di4,5; Zhang, Changming4,5; He, Lin1,2,34,35; Chen, Zi-Jiang4,5,6,7,15,36
发表日期2012-09
发表期刊NATURE GENETICS   影响因子和分区
语种英语
原始文献类型Article
其他关键词INSULIN-RECEPTOR GENE ; SUSCEPTIBILITY LOCI ; POLYMORPHISMS ; METAANALYSIS ; KNOWLEDGEBASE ; SUBFAMILY ; REACTOME ; PANTHER ; DEATH ; PART
摘要Following a previous genome-wide association study (GWAS 1) including 744 cases and 895 controls, we analyzed genome-wide association data from a new cohort of Han Chinese (GWAS 2) with 1,510 polycystic ovary syndrome (PCOS) cases and 2,016 controls. We followed up significantly associated signals identified in the combined results of GWAS 1 and 2 in a total of 8,226 cases and 7,578 controls. In addition to confirming the three loci we previously reported, we identify eight new PCOS association signals at P < 5 x 10(-8): 9q22.32, 11q22.1, 12q13.2, 12q14.3, 16q12.1, 19p13.3, 20q13.2 and a second independent signal at 2p16.3 (the FSHR gene). These PCOS association signals show evidence of enrichment for candidate genes related to insulin signaling, sexual hormone function and type 2 diabetes (T2D). Other candidate genes were related to calcium signaling and endocytosis. Our findings provide new insight and direction for discovering the biological mechanisms of PCOS.
资助项目National Basic Research Program of China (973 Program)National Basic Research Program of China [2012CB944700, 2010CB529600, 2011CB944502, 2010CB945002]; 863 ProgramNational High Technology Research and Development Program of China [2012AA02A515]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81130022, 30973170, 81121001, 31000553, 81000238, 81070461, 81000236]; National Key Technology Research and Development ProgramNational Key Technology R&D Program [2011BAI17B00]; Science Research Foundation Item of No-earnings Health Vocation [201002013]; Program for Changjiang Scholars and the Innovative Research Team in UniversityProgram for Changjiang Scholars & Innovative Research Team in University (PCSIRT) [IRT1025]; Foundation for the Author of National Excellent Doctoral Dissertation of ChinaFoundation for the Author of National Excellent Doctoral Dissertation of China [201026]; Program for New Century Excellent Talents in UniversityProgram for New Century Excellent Talents in University (NCET) [NCET-09-0550]
出版者NATURE RESEARCH
出版地BERLIN
ISSN1061-4036
EISSN1546-1718
卷号44期号:9页码:1020-+
DOI10.1038/ng.2384
页数8
WOS类目Genetics & Heredity
WOS研究方向Genetics & Heredity
WOS记录号WOS:000308491200013
收录类别SCIE ; SCOPUS
URL查看原文
PubMed ID22885925
SCOPUSEID2-s2.0-84865681750
CNS重要论文CNS重要论文
自科自定义期刊分类T2(A)类
通讯作者地址[He, Lin]Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders,Bio-X Institutes,Shanghai Jiao Tong University,China
Scopus学科分类Genetics
TOP期刊TOP期刊
引用统计
被引频次:380[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符https://kms.wmu.edu.cn/handle/3ETUA0LF/20859
专题附属第一医院
通讯作者He, Lin
作者单位
1.Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders,Bio-X Institutes,Shanghai Jiao Tong University,China;
2.Shanghai GenomePilot Institutes for Genomics and Human Health,China;
3.Changning Mental Health Center,China;
4.Center for Reproductive Medicine,Shandong Provincial Hospital,Shandong University,China;
5.National Research Center for Assisted Reproductive Technology and Reproductive Genetics,China;
6.Key Laboratory for Reproductive Endocrinology,Ministry of Education of the People's Republic of China,China;
7.Shandong Provincial Key Laboratory of Reproductive Medicine,China;
8.Reproductive Medicine Center,First Affiliated Hospital,Anhui Medical University,China;
9.Department of Obstetrics and Gynecology,Sun Yat-sen Memorial Hospital,Sun Yat-Sen University,China;
10.Reproductive Medicine Center,Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region,China;
11.Reproductive Medicine Center,Sixth Affiliated Hospital of Sun Yat-sen University,China;
12.Shanghai Institute of Mental Health,China;
13.Reproductive Medicine Unit,First Affiliated Hospital of Wenzhou Medical College,China;
14.Reproductive Medicine Center,Linyi People's Hospital,China;
15.Center for Reproductive Medicine,Renji Hospital,Shanghai Jiao Tong University School of Medicine,China;
16.National Institute of Hospital Administration,Ministry of Health of the People's Republic of China,China;
17.Reproductive Medicine Center,Affiliated Hospital of Ningxia Medical University,China;
18.Center for Reproductive Medicine,Qingdao Women and Children Medical Healthcare Center,China;
19.Reproductive Medicine Center,Affiliated Hospital of Jining Medical College,China;
20.Department of Obstetrics and Gynecology,First Affiliated Hospital of Nanjing Medical University,China;
21.Oncology Translational Medicine,GlaxoSmithKline R and D China,China;
22.Assisted Reproduction Center,Maternal and Child Health Care Hospital of Shaanxi Province,China;
23.Reproductive Medical Center,Renmin Hospital of Wuhan University,China;
24.Department of Obstetrics and Gynecology,105th Hospital of People's Liberation Army,China;
25.Department of Obstetrics and Gynecology,Affiliated Hospital of Medical College Qingdao University,China;
26.Department of Obstetrics and Gynecology,Jinan Health Institute of Maternity and Infant,China;
27.Reproductive Medical Center,Yantai Yuhuangding Hospital,China;
28.Department of Obstetrics and Gynecology,Tengzhou People's Hospital,China;
29.Reproductive Medical Center,Shengjing Hospital of China Medical University,China;
30.Department of Obstetrics and Gynecology,Affiliated Hospital of Weifang Medical College,China;
31.Department of Obstetrics and Gynecology,Anqiu People's Hospital,China;
32.Department of Gynecology, Obstetrics and Gynecology,Hospital of Fudan University,China;
33.Reproductive Medicine Unit,Weihai Women and Children Hospital,China;
34.Institutes of Biomedical Sciences,Fudan University,China;
35.Institute for Nutritional Sciences,Shanghai Institute of Biological Sciences,Chinese Academy of Sciences,China;
36.Bio-X Institutes,Shanghai Jiao Tong University,China
推荐引用方式
GB/T 7714
Shi, Yongyong,Zhao, Han,Shi, Yuhua,et al. Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome[J]. NATURE GENETICS,2012,44(9):1020-+.
APA Shi, Yongyong., Zhao, Han., Shi, Yuhua., Cao, Yunxia., Yang, Dongzi., ... & Chen, Zi-Jiang. (2012). Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome. NATURE GENETICS, 44(9), 1020-+.
MLA Shi, Yongyong,et al."Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome".NATURE GENETICS 44.9(2012):1020-+.

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