题名 | Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome |
作者 | Shi, Yongyong1,2,3; Zhao, Han4,5,6,7; Shi, Yuhua4,5,6,7; Cao, Yunxia8; Yang, Dongzi9; Li, Zhiqiang1,2,3; Zhang, Bo10; Liang, Xiaoyan11; Li, Tao4; Chen, Jianhua1,12; Shen, Jiawei1; Zhao, Junzhao13; You, Li4,5,6,7; Gao, Xuan4,5,6,7; Zhu, Dongyi14; Zhao, Xiaoming15; Yan, Ying16; Qin, Yingying4,5,6,7; Li, Wenjin1; Yan, Junhao4,5,6,7; Wang, Qingzhong1; Zhao, Junli17; Geng, Ling4,5,6,7; Ma, Jinlong4,5,6,7; Zhao, Yueran4,5,6,7; He, Guang1; Zhang, Aiping1; Zou, Shuhua18; Yang, Aijun19; Liu, Jiayin20; Li, Weidong1; Li, Baojie1; Wan, Chunling1; Qin, Ying21; Shi, Juanzi22; Yang, Jing23; Jiang, Hong24; Xu, Jin-E25; Qi, Xiujuan25; Sun, Yun15; Zhang, Yajie26; Hao, Cuifang27; Ju, Xiuqing28; Zhao, Dongni29; Ren, Chun-E30; Li, Xiuqing31; Zhang, Wei32; Zhang, Yiwen33; Zhang, Jiangtao4,5; Wu, Di4,5; Zhang, Changming4,5; He, Lin1,2,34,35; Chen, Zi-Jiang4,5,6,7,15,36
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发表日期 | 2012-09 |
发表期刊 | NATURE GENETICS 影响因子和分区 |
语种 | 英语 |
原始文献类型 | Article |
其他关键词 | INSULIN-RECEPTOR GENE ; SUSCEPTIBILITY LOCI ; POLYMORPHISMS ; METAANALYSIS ; KNOWLEDGEBASE ; SUBFAMILY ; REACTOME ; PANTHER ; DEATH ; PART |
摘要 | Following a previous genome-wide association study (GWAS 1) including 744 cases and 895 controls, we analyzed genome-wide association data from a new cohort of Han Chinese (GWAS 2) with 1,510 polycystic ovary syndrome (PCOS) cases and 2,016 controls. We followed up significantly associated signals identified in the combined results of GWAS 1 and 2 in a total of 8,226 cases and 7,578 controls. In addition to confirming the three loci we previously reported, we identify eight new PCOS association signals at P < 5 x 10(-8): 9q22.32, 11q22.1, 12q13.2, 12q14.3, 16q12.1, 19p13.3, 20q13.2 and a second independent signal at 2p16.3 (the FSHR gene). These PCOS association signals show evidence of enrichment for candidate genes related to insulin signaling, sexual hormone function and type 2 diabetes (T2D). Other candidate genes were related to calcium signaling and endocytosis. Our findings provide new insight and direction for discovering the biological mechanisms of PCOS. |
资助项目 | National Basic Research Program of China (973 Program)National Basic Research Program of China [2012CB944700, 2010CB529600, 2011CB944502, 2010CB945002]; 863 ProgramNational High Technology Research and Development Program of China [2012AA02A515]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81130022, 30973170, 81121001, 31000553, 81000238, 81070461, 81000236]; National Key Technology Research and Development ProgramNational Key Technology R&D Program [2011BAI17B00]; Science Research Foundation Item of No-earnings Health Vocation [201002013]; Program for Changjiang Scholars and the Innovative Research Team in UniversityProgram for Changjiang Scholars & Innovative Research Team in University (PCSIRT) [IRT1025]; Foundation for the Author of National Excellent Doctoral Dissertation of ChinaFoundation for the Author of National Excellent Doctoral Dissertation of China [201026]; Program for New Century Excellent Talents in UniversityProgram for New Century Excellent Talents in University (NCET) [NCET-09-0550] |
出版者 | NATURE RESEARCH |
出版地 | BERLIN |
ISSN | 1061-4036 |
EISSN | 1546-1718 |
卷号 | 44期号:9页码:1020-+ |
DOI | 10.1038/ng.2384 |
页数 | 8 |
WOS类目 | Genetics & Heredity |
WOS研究方向 | Genetics & Heredity |
WOS记录号 | WOS:000308491200013 |
收录类别 | SCIE ; SCOPUS |
URL | 查看原文 |
PubMed ID | 22885925 |
SCOPUSEID | 2-s2.0-84865681750 |
CNS重要论文 | CNS重要论文 |
自科自定义期刊分类 | T2(A)类 |
通讯作者地址 | [He, Lin]Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders,Bio-X Institutes,Shanghai Jiao Tong University,China |
Scopus学科分类 | Genetics |
TOP期刊 | TOP期刊 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.wmu.edu.cn/handle/3ETUA0LF/20859 |
专题 | 附属第一医院 |
通讯作者 | He, Lin |
作者单位 | 1.Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders,Bio-X Institutes,Shanghai Jiao Tong University,China; 2.Shanghai GenomePilot Institutes for Genomics and Human Health,China; 3.Changning Mental Health Center,China; 4.Center for Reproductive Medicine,Shandong Provincial Hospital,Shandong University,China; 5.National Research Center for Assisted Reproductive Technology and Reproductive Genetics,China; 6.Key Laboratory for Reproductive Endocrinology,Ministry of Education of the People's Republic of China,China; 7.Shandong Provincial Key Laboratory of Reproductive Medicine,China; 8.Reproductive Medicine Center,First Affiliated Hospital,Anhui Medical University,China; 9.Department of Obstetrics and Gynecology,Sun Yat-sen Memorial Hospital,Sun Yat-Sen University,China; 10.Reproductive Medicine Center,Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region,China; 11.Reproductive Medicine Center,Sixth Affiliated Hospital of Sun Yat-sen University,China; 12.Shanghai Institute of Mental Health,China; 13.Reproductive Medicine Unit,First Affiliated Hospital of Wenzhou Medical College,China; 14.Reproductive Medicine Center,Linyi People's Hospital,China; 15.Center for Reproductive Medicine,Renji Hospital,Shanghai Jiao Tong University School of Medicine,China; 16.National Institute of Hospital Administration,Ministry of Health of the People's Republic of China,China; 17.Reproductive Medicine Center,Affiliated Hospital of Ningxia Medical University,China; 18.Center for Reproductive Medicine,Qingdao Women and Children Medical Healthcare Center,China; 19.Reproductive Medicine Center,Affiliated Hospital of Jining Medical College,China; 20.Department of Obstetrics and Gynecology,First Affiliated Hospital of Nanjing Medical University,China; 21.Oncology Translational Medicine,GlaxoSmithKline R and D China,China; 22.Assisted Reproduction Center,Maternal and Child Health Care Hospital of Shaanxi Province,China; 23.Reproductive Medical Center,Renmin Hospital of Wuhan University,China; 24.Department of Obstetrics and Gynecology,105th Hospital of People's Liberation Army,China; 25.Department of Obstetrics and Gynecology,Affiliated Hospital of Medical College Qingdao University,China; 26.Department of Obstetrics and Gynecology,Jinan Health Institute of Maternity and Infant,China; 27.Reproductive Medical Center,Yantai Yuhuangding Hospital,China; 28.Department of Obstetrics and Gynecology,Tengzhou People's Hospital,China; 29.Reproductive Medical Center,Shengjing Hospital of China Medical University,China; 30.Department of Obstetrics and Gynecology,Affiliated Hospital of Weifang Medical College,China; 31.Department of Obstetrics and Gynecology,Anqiu People's Hospital,China; 32.Department of Gynecology, Obstetrics and Gynecology,Hospital of Fudan University,China; 33.Reproductive Medicine Unit,Weihai Women and Children Hospital,China; 34.Institutes of Biomedical Sciences,Fudan University,China; 35.Institute for Nutritional Sciences,Shanghai Institute of Biological Sciences,Chinese Academy of Sciences,China; 36.Bio-X Institutes,Shanghai Jiao Tong University,China |
推荐引用方式 GB/T 7714 | Shi, Yongyong,Zhao, Han,Shi, Yuhua,et al. Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome[J]. NATURE GENETICS,2012,44(9):1020-+. |
APA | Shi, Yongyong., Zhao, Han., Shi, Yuhua., Cao, Yunxia., Yang, Dongzi., ... & Chen, Zi-Jiang. (2012). Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome. NATURE GENETICS, 44(9), 1020-+. |
MLA | Shi, Yongyong,et al."Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome".NATURE GENETICS 44.9(2012):1020-+. |
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