Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3

doi:10.1038/ng.732

科研成果详情

题名	Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3
作者	Chen, Zi-Jiang 1,2; Zhao, Han 1,2; He, Lin 3,4,5; Shi, Yuhua 1,2; Qin, Yingying 1,2; Shi, Yongyong 4; Li, Zhiqiang 4; You, Li 1,2; Zhao, Junli 6; Liu, Jiayin 7; Liang, Xiaoyan 8; Zhao, Xiaoming 9; Zhao, Junzhao10; Sun, Yingpu 11; Zhang, Bo 12; Jiang, Hong 13; Zhao, Dongni 14; Bian, Yuehong 1,2; Gao, Xuan 1,2; Geng, Ling 1,2; Li, Yiran 15,16; Zhu, Dongyi 17; Sun, Xiuqin 18; Xu, Jin-E 19; Hao, Cuifang 20; Ren, Chun-E 16; Zhang, Yajie 21; Chen, Shiling 22; Zhang, Wei 23; Yang, Aijun 24; Yan, Junhao 1,2; Li, Yuan 1,2; Ma, Jinlong 1,2; Zhao, Yueran 1,2
发表日期	2011-01
发表期刊	NATURE GENETICS 影响因子和分区
语种	英语
原始文献类型	Article
其他关键词	HORMONE RECEPTOR GENE ; CHINESE WOMEN ; POLYMORPHISMS ; MUTATIONS ; DISEASE ; GLUCOSE ; METAANALYSIS ; PREVALENCE ; PROMOTER ; FAILURE
摘要	Polycystic ovary syndrome (PCOS) is a common metabolic disorder in women. To identify causative genes, we conducted a genome-wide association study (GWAS) of PCOS in Han Chinese. The discovery set included 744 PCOS cases and 895 controls; subsequent replications involved two independent cohorts (2,840 PCOS cases and 5,012 controls from northern Han Chinese; 498 cases and 780 controls from southern and central Han Chinese). We identified strong evidence of associations between PCOS and three loci: 2p16.3 (rs13405728; combined P-value by meta-analysis P-meta = 7.55 x 10(-21), odds ratio (OR) 0.71); 2p21 (rs13429458, P-meta = 1.73 x 10(-23), OR 0.67); and 9q33.3 (rs2479106, P-meta = 8.12 x 10(-19), OR 1.34). These findings provide new insight into the pathogenesis of PCOS. Follow-up studies of the candidate genes in these regions are recommended.
资助项目	National Basic Research Program of China (973 Program)National Basic Research Program of China [2006CB944004, 2010CB945000, 2007CB947403, 2007CB914703, 2007CB947300, 2010CB529600]; National 863 Project of ChinaNational High Technology Research and Development Program of China [2006AA02A407, 2009AA022701]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30973170]; Shanghai Municipal Commission of Science and Technology [09DJ1400601]
出版者	NATURE PUBLISHING GROUP
出版地	NEW YORK
ISSN	1061-4036
EISSN	1546-1718
卷号	43 期号:1 页码:55-U75
DOI	10.1038/ng.732
页数	6
WOS类目	Genetics & Heredity
WOS研究方向	Genetics & Heredity
WOS记录号	WOS:000285683500016
收录类别	SCIE ; SCOPUS
URL	查看原文
PubMed ID	21151128
SCOPUSEID	2-s2.0-78651256136
CNS重要论文	CNS重要论文
自科自定义期刊分类	T2(A)类
通讯作者地址	[Chen, Zi-Jiang]Center for Reproductive Medicine,Shandong Provincial Hospital,Shandong University,China
Scopus学科分类	Genetics
TOP期刊	TOP期刊
引用统计	被引频次：471[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/20782
专题	附属第一医院
通讯作者	Chen, Zi-Jiang
作者单位	1.Center for Reproductive Medicine,Shandong Provincial Hospital,Shandong University,China; 2.Shandong Key Laboratory of Reproductive Medicine,China; 3.Institutes of Biomedical Sciences,Fudan University,China; 4.Bio-X Center,Ministry of Education,Shanghai Jiao Tong University,China; 5.Institute for Nutritional Sciences,Shanghai Institutes of Biological Sciences,Chinese Academy of Sciences,China; 6.Affiliated Hospital,Ningxia Medical University,China; 7.First Affiliated Hospital,Nanjing Medical University,China; 8.Sixth Affiliated Hospital,Sun Yat Sen University,China; 9.Renji Hospital Affiliated,Shanghai Jiaotong University,China; 10.First Affiliated Hospital,Wenzhou Medical College,China; 11.First Affiliated Hospital,Zhengzhou University,China; 12.Maternal and Child Health Hospital in Guangxi,China; 13.105th Hospital of People's Liberation Army,China; 14.Shengjing Hospital,China Medical University,China; 15.Qingdao Women and Children Medical Healthcare Center,China; 16.Affiliated Hospital,Weifang Medical College,China; 17.Linyi People's Hospital,China; 18.Shandong Jingning First People's Hospital,China; 19.Affiliated Hospital,Medical College Qingdao University,China; 20.Yantai Yuhuangding Hospital,China; 21.Jinan Health Institute of Maternity and Infant,China; 22.Nanfang Hospital,China; 23.Obstetrics and Gynecology Hospital,Fudan University,China; 24.Affiliated Hospital,Jining Medical College,China
推荐引用方式 GB/T 7714	Chen, Zi-Jiang,Zhao, Han,He, Lin,et al. Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3[J]. NATURE GENETICS,2011,43(1):55-U75.
APA	Chen, Zi-Jiang., Zhao, Han., He, Lin., Shi, Yuhua., Qin, Yingying., ... & Zhao, Yueran. (2011). Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3. NATURE GENETICS, 43(1), 55-U75.
MLA	Chen, Zi-Jiang,et al."Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3".NATURE GENETICS 43.1(2011):55-U75.