Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3

doi:10.1038/ng.732

科研成果详情

题名	Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3
作者	Chen, Zi-Jiang 1,2; Zhao, Han 1,2; He, Lin 3,4,5; Shi, Yuhua 1,2; Qin, Yingying 1,2; Shi, Yongyong 4; Li, Zhiqiang 4; You, Li 1,2; Zhao, Junli 6; Liu, Jiayin 7; Liang, Xiaoyan 8; Zhao, Xiaoming 9; Zhao, Junzhao10; Sun, Yingpu 11; Zhang, Bo 12; Jiang, Hong ; Zhao, Dongni 13; Bian, Yuehong 1,2; Gao, Xuan 1,2; Geng, Ling 1,2; Li, Yiran 14,15; Zhu, Dongyi 16; Sun, Xiuqin 17; Xu, Jin-e 18; Hao, Cuifang 19; Ren, Chun-e 15; Zhang, Yajie 20; Chen, Shiling 21; Zhang, Wei 22; Yang, Aijun 23; Yan, Junhao 1,2; Li, Yuan 1,2; Ma, Jinlong 1,2; Zhao, Yueran 1,2
发表期刊	NATURE GENETICS 影响因子和分区
语种	英语
原始文献类型	Article
其他关键词	HORMONE RECEPTOR GENE ; CHINESE WOMEN ; POLYMORPHISMS ; MUTATIONS ; DISEASE ; GLUCOSE ; METAANALYSIS ; PREVALENCE ; PROMOTER ; FAILURE
摘要	Polycystic ovary syndrome (PCOS) is a common metabolic disorder in women. To identify causative genes, we conducted a genome-wide association study (GWAS) of PCOS in Han Chinese. The discovery set included 744 PCOS cases and 895 controls; subsequent replications involved two independent cohorts (2,840 PCOS cases and 5,012 controls from northern Han Chinese; 498 cases and 780 controls from southern and central Han Chinese). We identified strong evidence of associations between PCOS and three loci: 2p16.3 (rs13405728; combined P-value by meta-analysis P-meta = 7.55 x 10(-21), odds ratio (OR) 0.71); 2p21 (rs13429458, P-meta = 1.73 x 10(-23), OR 0.67); and 9q33.3 (rs2479106, P-meta = 8.12 x 10(-19), OR 1.34). These findings provide new insight into the pathogenesis of PCOS. Follow-up studies of the candidate genes in these regions are recommended.
资助项目	National Basic Research Program of China (973 Program)National Basic Research Program of China [2006CB944004, 2010CB945000, 2007CB947403, 2007CB914703, 2007CB947300, 2010CB529600]; National 863 Project of ChinaNational High Technology Research and Development Program of China [2006AA02A407, 2009AA022701]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30973170]; Shanghai Municipal Commission of Science and Technology [09DJ1400601]
出版者	NATURE PUBLISHING GROUP
出版地	NEW YORK
ISSN	1061-4036
EISSN	1546-1718
卷号	43 期号:1 页码:55-U75
DOI	10.1038/ng.732
WOS类目	Genetics & Heredity
WOS研究方向	Genetics & Heredity
WOS记录号	WOS:000285683500016
收录类别	SCIE ; SCOPUS
发表日期	2011-01
URL	查看原文
Scopus记录号	2-s2.0-78651256136
CNS重要论文	CNS重要论文
自科自定义期刊分类	T2(A)类
引用统计	被引频次：471[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/20782
专题	附属第一医院
通讯作者	Chen, Zi-Jiang
作者单位	1.Shandong Univ, Shandong Prov Hosp, Ctr Reprod Med, Jinan 250100, Shandong, Peoples R China; 2.Shandong Key Lab Reprod Med, Jinan, Shandong, Peoples R China; 3.Fudan Univ, Inst Biomed Sci, Shanghai 200433, Peoples R China; 4.Shanghai Jiao Tong Univ, Minist Educ, Key Lab Genet Dev & Neuropsychiat Disorders, Bio X Ctr, Shanghai 200030, Peoples R China; 5.Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Shanghai, Peoples R China; 6.Ningxia Med Univ, Affiliated Hosp, Ningxia, Peoples R China; 7.Nanjing Med Univ, Affiliated Hosp 1, Nanjing, Jiangsu, Peoples R China; 8.Sun Yat Sen Univ, Affiliated Hosp 6, Guangzhou, Guangdong, Peoples R China; 9.Shanghai Jiao Tong Univ, Renji Hosp, Shanghai 200030, Peoples R China; 10.Wenzhou Med Coll, Affiliated Hosp 1, Wenzhou, Zhejiang, Peoples R China; 11.Zhengzhou Univ, Affiliated Hosp 1, Zhengzhou, Henan, Peoples R China; 12.Maternal & Child Hlth Hosp Guangxi, Guangxi, Peoples R China; 13.China Med Univ, Shengjing Hosp, Liaoning, Peoples R China; 14.Qingdao Women & Children Med Healthcare Ctr, Qingdao, Shandong, Peoples R China; 15.Affiliated Hosp, Weifang Med Coll, Weifang, Shandong, Peoples R China; 16.Linyi Peoples Hosp, Linyi, Shandong, Peoples R China; 17.Shandong Jingning First Peoples Hosp, Jingning, Shandong, Peoples R China; 18.Qingdao Univ, Coll Med, Affiliated Hosp, Qingdao, Shandong, Peoples R China; 19.Yantai Yuhuangding Hosp, Yantai, Shandong, Peoples R China; 20.Jinan Hlth Inst Matern & Infant, Jinan, Shandong, Peoples R China; 21.Nanfang Hosp, Nanfang, Guangdong, Peoples R China; 22.Fudan Univ, Obstet & Gynecol Hosp, Shanghai 200433, Peoples R China; 23.Jining Med Coll, Affiliated Hosp, Jining, Shandong, Peoples R China
推荐引用方式 GB/T 7714	Chen, Zi-Jiang,Zhao, Han,He, Lin,et al. Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3[J]. NATURE GENETICS,2011,43(1):55-U75.
APA	Chen, Zi-Jiang., Zhao, Han., He, Lin., Shi, Yuhua., Qin, Yingying., ... & Zhao, Yueran. (2011). Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3. NATURE GENETICS, 43(1), 55-U75.
MLA	Chen, Zi-Jiang,et al."Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3".NATURE GENETICS 43.1(2011):55-U75.