Polyphenols Targeting NF-κB Pathway in Neurological Disorders: What We Know So Far?

doi:10.7150/ijbs.90982

科研成果详情

题名	Polyphenols Targeting NF-κB Pathway in Neurological Disorders: What We Know So Far?
作者	Abdullah Al Mamun 1,2; Chuxiao Shao1; Peiwu Geng1; Shuanghua Wang 1; Jian Xiao1,2,3
发表日期	2024
发表期刊	International journal of biological sciences 影响因子和分区
语种	英语
原始文献类型	Journal Article ; Review
关键词	Alzheimer's disease NF-κB pathway Neuroinflammation Parkinson's disease Polyphenols neurological disorders spinal cord injury
摘要	Polyphenolic compounds have shown promising neuroprotective properties, making them a valuable resource for identifying prospective drug candidates to treat several neurological disorders (NDs). Numerous studies have reported that polyphenols can disrupt the nuclear factor kappa B(NF-κB) pathway by inhibiting the phosphorylation or ubiquitination of signaling molecules, which further prevents the degradation of IκB. Additionally, they prevent NF-κB translocation to the nucleus and pro-inflammatory cytokine production. Polyphenols such as curcumin, resveratrol, and pterostilbene had significant inhibitory effects on NF-κB, making them promising candidates for treating NDs. Recent experimental findings suggest that polyphenols possess a wide range of pharmacological properties. Notably, much attention has been directed towards their potential therapeutic effects in NDs such as Alzheimer's disease (AD), Parkinson's disease (PD), cerebral ischemia, anxiety, depression, autism, and spinal cord injury (SCI). Much preclinical data supporting the neurotherapeutic benefits of polyphenols has been developed. Nevertheless, this study has described the significance of polyphenols as potential neurotherapeutic agents, specifically emphasizing their impact on the NF-κB pathway. This article offers a comprehensive analysis of the involvement of polyphenols in NDs, including both preclinical and clinical perspectives.
资助项目	National Natural Science Foundation of China[81972150,82172428];Zhejiang Provincial Natural Science Foundation of China[LQ21H090001];
ISSN	1449-2288
卷号	20 期号:4 页码:1332-1355
DOI	10.7150/ijbs.90982
收录类别	PUBMED ; SCOPUS
URL	查看原文
PubMed ID	38385077
SCOPUSEID	2-s2.0-85184440441
ESI高被引论文	2024-09 ; 2025-01
TOP期刊	TOP期刊
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/207693
专题	药学院（分析测试中心）
作者单位	1.Central Laboratory of The Sixth Affiliated Hospital of Wenzhou Medical University, Lishui People's Hospital, Lishui City, Zhejiang 323000, China.; 2.Molecular Pharmacology Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325000, China.; 3.Department of Wound Healing, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
第一作者单位	温州医科大学; 药学院（分析测试中心）
第一作者的第一单位	温州医科大学
推荐引用方式 GB/T 7714	Abdullah Al Mamun,Chuxiao Shao,Peiwu Geng,et al. Polyphenols Targeting NF-κB Pathway in Neurological Disorders: What We Know So Far?[J]. International journal of biological sciences,2024,20(4):1332-1355.
APA	Abdullah Al Mamun, Chuxiao Shao, Peiwu Geng, Shuanghua Wang, & Jian Xiao. (2024). Polyphenols Targeting NF-κB Pathway in Neurological Disorders: What We Know So Far?. International journal of biological sciences, 20(4), 1332-1355.
MLA	Abdullah Al Mamun,et al."Polyphenols Targeting NF-κB Pathway in Neurological Disorders: What We Know So Far?".International journal of biological sciences 20.4(2024):1332-1355.