题名 | Reconstruction and Simulation of Neocortical Microcircuitry |
作者 | Markram, Henry1,2; Muller, Eilif1; Ramaswamy, Srikanth1; Reimann, Michael W.1; Abdellah, Marwan1; Sanchez, Carlos Aguado1; Ailamaki, Anastasia16; Alonso-Nanclares, Lidia6,7; Antille, Nicolas1; Arsever, Selim1; Kahou, Guy Antoine Atenekeng1; Berger, Thomas K.2; Bilgili, Ahmet1; Buncic, Nenad1; Chalimourda, Athanassia1; Chindemi, Giuseppe1; Courcol, Jean-Denis1; Delalondre, Fabien1; Delattre, Vincent2; Druckmann, Shaul4,5; Dumusc, Raphael1; Dynes, James1; Eilemann, Stefan1; Gal, Eyal4; Gevaert, Michael Emiel1; Ghobril, Jean-Pierre2; Gidon, Albert3; Graham, Joe W.1; Gupta, Anirudh2; Haenel, Valentin1; Hay, Etay3,4; Heinis, Thomas1,16,17; Hernando, Juan B.8; Hines, Michael12; Kanari, Lida1; Keller, Daniel1; Kenyon, John1; Khazen, Georges1; Kim, Yihwa1; King, James G.1; Kisvarday, Zoltan13; Kumbhar, Pramod1; Lasserre, Sébastien1,15; Le Bé, Jean-Vincent2; Magalhães, Bruno R.C.1; Merchán-Pérez, Angel6,7; Meystre, Julie2; Morrice, Benjamin Roy1; Muller, Jeffrey1; Muñoz-Céspedes, Alberto6,7; Muralidhar, Shruti2; Muthurasa, Keerthan1; Nachbaur, Daniel1; Newton, Taylor H.1; Nolte, Max1; Ovcharenko, Aleksandr1; Palacios, Juan1; Pastor, Luis9; Perin, Rodrigo2; Ranjan, Rajnish1,2; Riachi, Imad1; Rodríguez, José-Rodrigo6,7; Riquelme, Juan Luis1; Rössert, Christian1; Sfyrakis, Konstantinos1; Shi, Ying1,2; Shillcock, Julian C.1; Silberberg, Gilad18; Silva, Ricardo1; Tauheed, Farhan1,16; Telefont, Martin1; Toledo-Rodriguez, Maria14; Tränkler, Thomas1; Van Geit, Werner1; Díaz, Jafet Villafranca1; Walker, Richard1; Wang, Yun10,11; Zaninetta, Stefano M.1; Defelipe, Javier6,7; Hill, Sean L.1; Segev, Idan3,4; Schürmann, Felix1
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发表日期 | 2015-10-08 |
发表期刊 | CELL 影响因子和分区 |
语种 | 英语 |
原始文献类型 | Article |
其他关键词 | RAT SOMATOSENSORY CORTEX ; LAYER-5 PYRAMIDAL NEURONS ; PARVALBUMIN-POSITIVE INTERNEURONS ; TRANSMITTER RELEASE MODULATION ; DUAL INTRACELLULAR-RECORDINGS ; PARALLEL NETWORK SIMULATIONS ; CORTICAL NONPYRAMIDAL CELLS ; GENE-EXPRESSION PROFILES ; MOUSE BARREL CORTEX ; ACTIVITY IN-VIVO |
摘要 | We present a first-draft digital reconstruction of the microcircuitry of somatosensory cortex of juvenile rat. The reconstruction uses cellular and synaptic organizing principles to algorithmically reconstruct detailed anatomy and physiology from sparse experimental data. An objective anatomical method defines a neocortical volume of 0.29 +/- 0.01 mm(3) containing similar to 31,000 neurons, and patch-clamp studies identify 55 layer-specific morphological and 207 morphoelectrical neuron subtypes. When digitally reconstructed neurons are positioned in the volume and synapse formation is restricted to biological bouton densities and numbers of synapses per connection, their overlapping arbors form similar to 8 million connections with similar to 37 million synapses. Simulations reproduce an array of in vitro and in vivo experiments without parameter tuning. Additionally, we find a spectrum of network states with a sharp transition from synchronous to asynchronous activity, modulated by physiological mechanisms. The spectrum of network states, dynamically reconfigured around this transition, supports diverse information processing strategies. |
资助项目 | EPFL; ETH Domain for the Blue Brain Project (BBP); European UnionEuropean Commission [604102]; Gatsby Charitable Foundation; Cajal Blue Brain Project, Ministerio de Economia y Competitividad Spanish Ministry of Education and Science; EPFL-Hebrew University Collaborative Grant; Canton of Geneva; Canton of Vaud; Hans Wilsdorf Foundation; Louis-Jeantet Foundation; University of Geneva; University of Lausanne; Ecole Polytechnique Federale de Lausanne; ETH Board Funding |
出版者 | CELL PRESS |
出版地 | CAMBRIDGE |
ISSN | 0092-8674 |
EISSN | 1097-4172 |
卷号 | 163期号:2页码:456-492 |
DOI | 10.1016/j.cell.2015.09.029 |
页数 | 37 |
WOS类目 | Biochemistry & Molecular Biology ; Cell Biology |
WOS研究方向 | Biochemistry & Molecular Biology ; Cell Biology |
WOS记录号 | WOS:000362952700021 |
收录类别 | SCIE ; PUBMED ; SCOPUS |
URL | 查看原文 |
PubMed ID | 26451489 |
SCOPUSEID | 2-s2.0-84943612722 |
ESI高被引论文 | 2020-01 ; 2020-03 ; 2020-05 ; 2020-09 ; 2020-11 ; 2021-01 ; 2021-03 ; 2021-05 ; 2021-07 ; 2021-09 ; 2021-11 ; 2022-01 ; 2022-03 ; 2022-07 ; 2022-09 ; 2022-11 ; 2023-01 ; 2023-03 ; 2023-05 ; 2023-07 ; 2023-09 ; 2023-11 ; 2024-01 ; 2024-03 ; 2024-05 ; 2024-07 ; 2024-09 |
CNS重要论文 | CNS重要论文 |
自科自定义期刊分类 | T1类 |
通讯作者地址 | [Markram, Henry]Blue Brain Project,École Polytechnique Fédérale de Lausanne (EPFL),Biotech Campus,Geneva,1202,Switzerland |
Scopus学科分类 | Biochemistry, Genetics and Molecular Biology (all) |
TOP期刊 | TOP期刊 |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.wmu.edu.cn/handle/3ETUA0LF/20767 |
专题 | 眼视光学院(生物医学工程学院)、附属眼视光医院 |
通讯作者 | Markram, Henry |
作者单位 | 1.Blue Brain Project,École Polytechnique Fédérale de Lausanne (EPFL),Biotech Campus,Geneva,1202,Switzerland; 2.Laboratory of Neural Microcircuitry,Brain Mind Institute,EPFL,Lausanne,1015,Switzerland; 3.Department of Neurobiology,Alexander Silberman Institute of Life Sciences,Hebrew University of Jerusalem,Jerusalem,91904,Israel; 4.Edmond and Lily Safra Center for Brain Sciences,Hebrew University of Jerusalem,Jerusalem,91904,Israel; 5.Janelia Farm Research Campus,Howard Hughes Medical Institute,Ashburn,20147,United States; 6.Laboratorio Cajal de Circuitos Corticales,Centro de Tecnología Biomédica,Universidad Politécnica de Madrid,Madrid,28223,Spain; 7.Instituto Cajal (CSIC),CIBERNED,Madrid,28002,Spain; 8.CeSViMa,Centro de Supercomputación y Visualización de Madrid,Universidad Politécnica de Madrid,Madrid,28223,Spain; 9.Modeling and Virtual Reality Group,Universidad Rey Juan Carlos,Móstoles, Madrid,28933,Spain; 10.Key Laboratory of Visual Science and National Ministry of Health,School of Optometry and Opthalmology,Wenzhou Medical College,Wenzhou,325003,China; 11.Caritas St. Elizabeth's Medical Center,Genesys Research Institute,Tufts University,Boston,02111,United States; 12.Department of Neurobiology,Yale University,New Haven,06510,United States; 13.MTA-Debreceni Egyetem,Neuroscience Research Group,Debrecen,4032,Hungary; 14.School of Life Sciences,University of Nottingham,Nottingham,NG7 2UH,United Kingdom; 15.Laboratoire d'Informatique et de Visualisation,EPFL,Lausanne,1015,Switzerland; 16.Data-Intensive Applications and Systems Lab,EPFL,Lausanne,1015,Switzerland; 17.Imperial College London,London,SW7 2AZ,United Kingdom; 18.Department of Neuroscience,Karolinska Institutet,Stockholm,17177,Sweden |
推荐引用方式 GB/T 7714 | Markram, Henry,Muller, Eilif,Ramaswamy, Srikanth,et al. Reconstruction and Simulation of Neocortical Microcircuitry[J]. CELL,2015,163(2):456-492. |
APA | Markram, Henry., Muller, Eilif., Ramaswamy, Srikanth., Reimann, Michael W.., Abdellah, Marwan., ... & Schürmann, Felix. (2015). Reconstruction and Simulation of Neocortical Microcircuitry. CELL, 163(2), 456-492. |
MLA | Markram, Henry,et al."Reconstruction and Simulation of Neocortical Microcircuitry".CELL 163.2(2015):456-492. |
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