Biomaterial-assisted strategies to improve islet graft revascularization and transplant outcomes

doi:10.1039/d3bm01295f

科研成果详情

题名	Biomaterial-assisted strategies to improve islet graft revascularization and transplant outcomes
作者	Qi, Boyang1; Ding, Yang2; Zhang, Ying1; Kou, Longfa3; Zhao, Ying-Zheng1; Yao, Qing1,4
发表日期	2024-02-13
发表期刊	BIOMATERIALS SCIENCE 影响因子和分区
语种	英语
原始文献类型	Review ; Early Access ; Journal article (JA)
关键词	Cardiovascular system Insulin release Islet transplantation Local regulations Revascularization Secretion function Survival Function Type 1 diabetes Vascular network Vascular system Vascularization
其他关键词	ENDOTHELIAL GROWTH-FACTOR ; DECREASED OXYGEN-TENSION ; IN-VIVO ; CONTROLLED-RELEASE ; OXIDATIVE STRESS ; ANTERIOR-CHAMBER ; VEGF ; TISSUE ; MATRIX ; CELLS
摘要	Islet transplantation holds significant promise as a curative approach for type 1 diabetes (T1D). However, the transition of islet transplantation from the experimental phase to widespread clinical implementation has not occurred yet. One major hurdle in this field is the challenge of insufficient vascularization and subsequent early loss of transplanted islets, especially in non-intraportal transplantation sites. The establishment of a fully functional vascular system following transplantation is crucial for the survival and secretion function of islet grafts. This vascular network not only ensures the delivery of oxygen and nutrients, but also plays a critical role in insulin release and the timely removal of metabolic waste from the grafts. This review summarizes recent advances in effective strategies to improve graft revascularization and enhance islet survival. These advancements include the local release and regulation of angiogenic factors (e.g., vascular endothelial growth factor, VEGF), co-transplantation of vascular fragments, and pre-vascularization of the graft site. These innovative approaches pave the way for the development of effective islet transplantation therapies for individuals with T1D. Islet transplantation holds significant promise as a curative approach for type 1 diabetes (T1D).
资助项目	Natural Science Foundation of Zhejiang Province [82372112]; National Natural Science Foundation of China [Y23H300012]; Zhejiang Province Natural Science Foundation [2022KY881, 2023KY884]; Zhejiang Medical and Health Science and Technology Program [Y20220908]; Wenzhou Municipal Science and Technology Bureau; Zhejiang provincial program for the cultivation of high-level innovative health talents; Excellent Young Scientist Training Program fund from Wenzhou Medical University
出版者	ROYAL SOC CHEMISTRY
ISSN	2047-4830
EISSN	2047-4849
卷号	12 期号:4 页码:821-836
DOI	10.1039/d3bm01295f
页数	16
WOS类目	Materials Science, Biomaterials
WOS研究方向	Materials Science
WOS记录号	WOS:001135738600001
收录类别	SCIE ; PUBMED ; SCOPUS ; EI
在线发表日期	2024-01
EI入藏号	20240315388598
EI主题词	Grafts
EI分类号	461.2 Biological Materials and Tissue Engineering ; 462.4 Prosthetics
URL	查看原文
PubMed ID	38168805
SCOPUSEID	2-s2.0-85182173048
通讯作者地址	[Yao, Qing]School of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou,325035,China
Scopus学科分类	Biomedical Engineering;Materials Science (all)
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/207269
专题	药学院（分析测试中心）附属第二医院第二临床医学院、附属第二医院、育英儿童医院其他_温州医科大学慈溪生物医药研究院
通讯作者	Yao, Qing
作者单位	1.School of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou,325035,China; 2.The Second School of Medicine,Wenzhou Medical University,Wenzhou,China; 3.The Second Affiliated Hospital of Wenzhou Medical University,Zhejiang Province,Wenzhou,China; 4.Cixi Biomedical Research Institute,Wenzhou Medical University,Zhejiang,China
第一作者单位	药学院（分析测试中心）
通讯作者单位	药学院（分析测试中心）
第一作者的第一单位	药学院（分析测试中心）
推荐引用方式 GB/T 7714	Qi, Boyang,Ding, Yang,Zhang, Ying,et al. Biomaterial-assisted strategies to improve islet graft revascularization and transplant outcomes[J]. BIOMATERIALS SCIENCE,2024,12(4):821-836.
APA	Qi, Boyang, Ding, Yang, Zhang, Ying, Kou, Longfa, Zhao, Ying-Zheng, & Yao, Qing. (2024). Biomaterial-assisted strategies to improve islet graft revascularization and transplant outcomes. BIOMATERIALS SCIENCE, 12(4), 821-836.
MLA	Qi, Boyang,et al."Biomaterial-assisted strategies to improve islet graft revascularization and transplant outcomes".BIOMATERIALS SCIENCE 12.4(2024):821-836.