科研成果详情

题名Oat β-glucan repairs the epidermal barrier by upregulating the levels of epidermal differentiation, cell-cell junctions and lipids via Dectin-1
作者
发表日期2024-06
发表期刊BRITISH JOURNAL OF PHARMACOLOGY   影响因子和分区
语种英语
原始文献类型Article ; Early Access ; Journal Article
关键词cell-cell junctions Dectin-1 Differenation epidermal barrier lipids oat beta-glucan Cell-cell junctions Epidermal barrier Lipids Oat β-glucan
其他关键词KERATINOCYTE DIFFERENTIATION ; TIGHT JUNCTIONS ; CONCISE GUIDE ; SKIN ; PERMEABILITY ; CALCIUM ; PROLIFERATION ; EXPRESSION ; MIGRATION ; PROTEINS
摘要Background and purpose: Oat beta-glucan could ameliorate epidermal hyperplasia and accelerate epidermal barrier repair. Dectin-1 is one of the receptors of beta-glucan and many biological functions of beta-glucan are mediated by Dectin-1. Dectin-1 promotes wound healing through regulating the proliferation and migration of skin cells. Thus, this study aimed to investigate the role of oat beta-glucan and Dectin-1 in epidermal barrier repair. Experimental approach: To investigate the role of Dectin-1 in the epidermal barrier, indicators associated with the recovery of a damaged epidermal barrier, including histopathological changes, keratinization, proliferation, apoptosis, differentiation, cell-cell junctions and lipid content were compared between WT and Dectin-1(-/-) mice. Further, the effect of oat beta-glucan on the disruption of the epidermal barrier was also compared between WT and Dectin-1(-/-) mice. Key results: Dectin-1 deficiency resulted in delayed recovery and marked keratinization, as well as abnormal levels of keratinocyte differentiation, cell-cell junctions and lipid synthesis during the restoration of the epidermal barrier. Oat beta-glucan significantly reduces epidermal hyperplasia, promotes epidermal differentiation, increases cell-cell junction expression, promotes lipid synthesis and ultimately accelerates the recovery of damaged epidermal barriers via Dectin-1. Oat beta-glucan could promote CaS receptor expression and activate the PPAR-gamma signalling pathway via Dectin-1. Conclusion and implications: Oat beta-glucan promote the recovery of damaged epidermal barriers through promoting epidermal differentiation, increasing the expression of cell-cell junctions and lipid synthesis through Dectin-1. Dectin-1 deficiency delay the recovery of epidermal barriers, which indicated that Dectin-1 may be a potential target in epidermal barrier repair.
资助项目National Natural Science Foundation of China; [81903736]
出版者WILEY
ISSN0007-1188
EISSN1476-5381
卷号181期号:11页码:1596-1613
DOI10.1111/bph.16306
页数18
WOS类目Pharmacology & Pharmacy
WOS研究方向Pharmacology & Pharmacy
WOS记录号WOS:001152569200001
收录类别SCIE ; SCOPUS ; PUBMED
在线发表日期2024-01
URL查看原文
PubMed ID38124222
SCOPUSEID2-s2.0-85183853495
通讯作者地址[Li, Xiaokun]School of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou,325035,China ; [Gao, Shuang]School of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou,China ; [Li, Zhiming]Department of Dermatology and Venereology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325005,China
Scopus学科分类Pharmacology
引用统计
文献类型期刊论文
条目标识符https://kms.wmu.edu.cn/handle/3ETUA0LF/207216
专题药学院(分析测试中心)
附属第一医院
第一临床医学院(信息与工程学院)、附属第一医院_皮肤病与性病学_皮肤性病科
通讯作者Li, Xiaokun; Li, Zhiming; Gao, Shuang
作者单位
1.School of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou,China;
2.College of Life and Environmental Sciences,Wenzhou University,Wenzhou,China;
3.Department of Dermatology and Venereology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
第一作者单位药学院(分析测试中心)
通讯作者单位药学院(分析测试中心);  附属第一医院;  第一临床医学院(信息与工程学院)、附属第一医院
第一作者的第一单位药学院(分析测试中心)
推荐引用方式
GB/T 7714
Jing, Rongrong,Fu, Mengli,Huang, Yuhan,et al. Oat β-glucan repairs the epidermal barrier by upregulating the levels of epidermal differentiation, cell-cell junctions and lipids via Dectin-1[J]. BRITISH JOURNAL OF PHARMACOLOGY,2024,181(11):1596-1613.
APA Jing, Rongrong., Fu, Mengli., Huang, Yuhan., Zhang, Kaini., Ye, Jiabin., ... & Gao, Shuang. (2024). Oat β-glucan repairs the epidermal barrier by upregulating the levels of epidermal differentiation, cell-cell junctions and lipids via Dectin-1. BRITISH JOURNAL OF PHARMACOLOGY, 181(11), 1596-1613.
MLA Jing, Rongrong,et al."Oat β-glucan repairs the epidermal barrier by upregulating the levels of epidermal differentiation, cell-cell junctions and lipids via Dectin-1".BRITISH JOURNAL OF PHARMACOLOGY 181.11(2024):1596-1613.

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