题名 | Oat β-glucan repairs the epidermal barrier by upregulating the levels of epidermal differentiation, cell-cell junctions and lipids via Dectin-1 |
作者 | |
发表日期 | 2024-06 |
发表期刊 | BRITISH JOURNAL OF PHARMACOLOGY 影响因子和分区 |
语种 | 英语 |
原始文献类型 | Article ; Early Access ; Journal Article |
关键词 | cell-cell junctions Dectin-1 Differenation epidermal barrier lipids oat beta-glucan Cell-cell junctions Epidermal barrier Lipids Oat β-glucan |
其他关键词 | KERATINOCYTE DIFFERENTIATION ; TIGHT JUNCTIONS ; CONCISE GUIDE ; SKIN ; PERMEABILITY ; CALCIUM ; PROLIFERATION ; EXPRESSION ; MIGRATION ; PROTEINS |
摘要 | Background and purpose: Oat beta-glucan could ameliorate epidermal hyperplasia and accelerate epidermal barrier repair. Dectin-1 is one of the receptors of beta-glucan and many biological functions of beta-glucan are mediated by Dectin-1. Dectin-1 promotes wound healing through regulating the proliferation and migration of skin cells. Thus, this study aimed to investigate the role of oat beta-glucan and Dectin-1 in epidermal barrier repair. Experimental approach: To investigate the role of Dectin-1 in the epidermal barrier, indicators associated with the recovery of a damaged epidermal barrier, including histopathological changes, keratinization, proliferation, apoptosis, differentiation, cell-cell junctions and lipid content were compared between WT and Dectin-1(-/-) mice. Further, the effect of oat beta-glucan on the disruption of the epidermal barrier was also compared between WT and Dectin-1(-/-) mice. Key results: Dectin-1 deficiency resulted in delayed recovery and marked keratinization, as well as abnormal levels of keratinocyte differentiation, cell-cell junctions and lipid synthesis during the restoration of the epidermal barrier. Oat beta-glucan significantly reduces epidermal hyperplasia, promotes epidermal differentiation, increases cell-cell junction expression, promotes lipid synthesis and ultimately accelerates the recovery of damaged epidermal barriers via Dectin-1. Oat beta-glucan could promote CaS receptor expression and activate the PPAR-gamma signalling pathway via Dectin-1. Conclusion and implications: Oat beta-glucan promote the recovery of damaged epidermal barriers through promoting epidermal differentiation, increasing the expression of cell-cell junctions and lipid synthesis through Dectin-1. Dectin-1 deficiency delay the recovery of epidermal barriers, which indicated that Dectin-1 may be a potential target in epidermal barrier repair. |
资助项目 | National Natural Science Foundation of China; [81903736] |
出版者 | WILEY |
ISSN | 0007-1188 |
EISSN | 1476-5381 |
卷号 | 181期号:11页码:1596-1613 |
DOI | 10.1111/bph.16306 |
页数 | 18 |
WOS类目 | Pharmacology & Pharmacy |
WOS研究方向 | Pharmacology & Pharmacy |
WOS记录号 | WOS:001152569200001 |
收录类别 | SCIE ; SCOPUS ; PUBMED |
在线发表日期 | 2024-01 |
URL | 查看原文 |
PubMed ID | 38124222 |
SCOPUSEID | 2-s2.0-85183853495 |
通讯作者地址 | [Li, Xiaokun]School of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou,325035,China ; [Gao, Shuang]School of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou,China ; [Li, Zhiming]Department of Dermatology and Venereology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325005,China |
Scopus学科分类 | Pharmacology |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.wmu.edu.cn/handle/3ETUA0LF/207216 |
专题 | 药学院(分析测试中心) 附属第一医院 第一临床医学院(信息与工程学院)、附属第一医院_皮肤病与性病学_皮肤性病科 |
通讯作者 | Li, Xiaokun; Li, Zhiming; Gao, Shuang |
作者单位 | 1.School of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou,China; 2.College of Life and Environmental Sciences,Wenzhou University,Wenzhou,China; 3.Department of Dermatology and Venereology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China |
第一作者单位 | 药学院(分析测试中心) |
通讯作者单位 | 药学院(分析测试中心); 附属第一医院; 第一临床医学院(信息与工程学院)、附属第一医院 |
第一作者的第一单位 | 药学院(分析测试中心) |
推荐引用方式 GB/T 7714 | Jing, Rongrong,Fu, Mengli,Huang, Yuhan,et al. Oat β-glucan repairs the epidermal barrier by upregulating the levels of epidermal differentiation, cell-cell junctions and lipids via Dectin-1[J]. BRITISH JOURNAL OF PHARMACOLOGY,2024,181(11):1596-1613. |
APA | Jing, Rongrong., Fu, Mengli., Huang, Yuhan., Zhang, Kaini., Ye, Jiabin., ... & Gao, Shuang. (2024). Oat β-glucan repairs the epidermal barrier by upregulating the levels of epidermal differentiation, cell-cell junctions and lipids via Dectin-1. BRITISH JOURNAL OF PHARMACOLOGY, 181(11), 1596-1613. |
MLA | Jing, Rongrong,et al."Oat β-glucan repairs the epidermal barrier by upregulating the levels of epidermal differentiation, cell-cell junctions and lipids via Dectin-1".BRITISH JOURNAL OF PHARMACOLOGY 181.11(2024):1596-1613. |
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