Innate immune responsive inflammation in development of progressive myopia

doi:10.1038/s41433-024-02947-z

科研成果详情

题名	Innate immune responsive inflammation in development of progressive myopia
作者	Pan, Suqi1; Yuan, Jianshu 1; Jin, Yuanhui 2; Liu, Xiaotian1; Wu, Shanjun 1; Wang, Yuwen1; Yao, Hongyan1; Cheng, Lingyun 3
发表日期	2024-01-29
发表期刊	EYE 影响因子和分区
语种	英语
原始文献类型	Article ; Early Access
其他关键词	ENDOTHELIAL GROWTH-FACTOR ; BLOOD-RETINAL BARRIER ; AQUEOUS-HUMOR LEVELS ; CLINICAL-EVIDENCE ; EXPRESSION ; ICAM-1 ; DEGENERATION ; TGF-BETA-2 ; CYTOKINES ; VISION
摘要	PurposeInflammation has been implicated for development of myopia. It is not clear when inflammation is kicked in during the course of myopia, and what characteristics of the inflammation. In this study, we tested for cytokines from aqueous humour of eyes with wide spectrum of refractive status for profiling the inflammation.MethodsAqueous humour of 142 patient eyes were tested for soluble intercellular adhesion molecule 1 (sICAM-1), monocyte chemoattractant protein-1 (MCP-1), and transforming growth factor-beta 2 (TGF-beta 2) using an enzyme-linked immunosorbent assay (ELISA). Eye globe axial length of these patients ranged from emmetropia to high myopia.ResultsOf 142 patients, an average axial length is 25.51 +/- 3.31 mm, with a range of 21.56-34.37 mm. There are 36 cases in lower 25 percentile, 37 cases in upper 25 percentile, and 69 case in the middle 50 percentile. sICAM-1 and MCP-1 were significantly higher in the eyes with staphyloma (407.48 pg/mL, 312.31 pg/mL, n = 33) or macular schisis (445.86 pg/mL,345.33 pg/mL, n = 19) than that in the eyes without these changes (206.44 pg/mL, 244.76 pg/mL, n = 107). All three cytokines level was significantly associated with eye globe axial in a positive mode while adjusting for the age and sex. Strength of the association was the greatest for sICAM-1 and the weakest for TGF- beta 2. MCP-1 was in between.ConclusionsICAM-1 and MCP-1 in ocular fluid may be indicative biomarkers for progressive high myopia and the underneath autoimmune inflammation. sICAM-1 may be used as a monitoring biomarker for development of pathologic myopia.
资助项目	Zhejiang Health Science and Technology Program [2021PY074]; Ningbo Yinzhou District Agricultural Social Science and Technology project [2021AS0056]
出版者	SPRINGERNATURE
ISSN	0950-222X
EISSN	1476-5454
卷号	38 期号:8 页码:1542-1548
DOI	10.1038/s41433-024-02947-z
页数	7
WOS类目	Ophthalmology
WOS研究方向	Ophthalmology
WOS记录号	WOS:001153684900002
收录类别	SCIE ; PUBMED ; SCOPUS
在线发表日期	2024-01
URL	查看原文
PubMed ID	38287111
SCOPUSEID	2-s2.0-85183378347
通讯作者地址	[Cheng, Lingyun]Jacob’s Retina Center at Shiley Eye Institute,Department of Ophthalmology,University of California San Diego,La Jolla,United States
Scopus学科分类	Ophthalmology;Sensory Systems
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/207061
专题	其他_附属宁波市眼科医院
通讯作者	Cheng, Lingyun
作者单位	1.The Affiliated Ningbo Eye Hospital of Wenzhou Medical University,Ningbo,China; 2.Department of Ophthalmology,Dongyang People’s Hospital,Dongyang,China; 3.Jacob’s Retina Center at Shiley Eye Institute,Department of Ophthalmology,University of California San Diego,La Jolla,United States
第一作者单位	其他_附属宁波市眼科医院
第一作者的第一单位	其他_附属宁波市眼科医院
推荐引用方式 GB/T 7714	Pan, Suqi,Yuan, Jianshu,Jin, Yuanhui,et al. Innate immune responsive inflammation in development of progressive myopia[J]. EYE,2024,38(8):1542-1548.
APA	Pan, Suqi., Yuan, Jianshu., Jin, Yuanhui., Liu, Xiaotian., Wu, Shanjun., ... & Cheng, Lingyun. (2024). Innate immune responsive inflammation in development of progressive myopia. EYE, 38(8), 1542-1548.
MLA	Pan, Suqi,et al."Innate immune responsive inflammation in development of progressive myopia".EYE 38.8(2024):1542-1548.