Crohn's disease as the intestinal manifestation of pan-lymphatic dysfunction: An exploratory proposal based on basic and clinical data

doi:10.3748/wjg.v30.i1.34

科研成果详情

题名	Crohn's disease as the intestinal manifestation of pan-lymphatic dysfunction: An exploratory proposal based on basic and clinical data
作者	Zhou, Yu-Wei 1; Ren, Yue 2; Lu, Miao-Miao 3; Xu, Ling-Ling 4; Cheng, Wei-Xin 1; Zhang, Meng-Meng 5; Ding, Lin-Ping 1; Chen, Dong 6; Gao, Jian-Guo 1; Du, Juan 1; Jin, Ci-Liang7; Chen, Chun-Xiao 1; Li, Yun-Fei 8; Cheng, Tao 8; Jiang, Peng-Lei 9; Yang, Yi-Da 10; Qian, Peng-Xu 9; Xu, Peng-Fei 8; Jin, Xi 1,11
发表日期	2024-01-07
发表期刊	WORLD JOURNAL OF GASTROENTEROLOGY 影响因子和分区
语种	英语
原始文献类型	Review
关键词	Inflammatory bowel disease Crohn's disease Lymphatic system Inside-out model Immune cells Zebrafish
其他关键词	INFLAMMATION-INDUCED LYMPHANGIOGENESIS ; HIGH-DENSITY-LIPOPROTEINS ; TERTIARY LYMPHOID ORGANS ; NF-KAPPA-B ; MAINTENANCE THERAPY ; INCREASED SUSCEPTIBILITY ; DENDRITIC CELLS ; PEYERS-PATCHES ; MESENTERIC FAT ; BOWEL-DISEASE
摘要	Crohn's disease (CD) is caused by immune, environmental, and genetic factors. It can involve the entire gastrointestinal tract, and although its prevalence is rapidly increasing its etiology remains unclear. Emerging biological and small-molecule drugs have advanced the treatment of CD; however, a considerable proportion of patients are non-responsive to all known drugs. To achieve a breakthrough in this field, innovations that could guide the further development of effective therapies are of utmost urgency. In this review, we first propose the innovative concept of pan-lymphatic dysfunction for the general distribution of lymphatic dysfunction in various diseases, and suggest that CD is the intestinal manifestation of pan-lymphatic dysfunction based on basic and clinical preliminary data. The supporting evidence is fully summarized, including the existence of lymphatic system dysfunction, recognition of the inside-out model, disorders of immune cells, changes in cell plasticity, partial overlap of the underlying mechanisms, and common gut-derived fatty and bile acid metabolism. Another benefit of this novel concept is that it proposes adopting the zebrafish model for studying intestinal diseases, especially CD, as this model is good at presenting and mimicking lymphatic dysfunction. More importantly, the ensuing focus on improving lymphatic function may lead to novel and promising therapeutic strategies for CD.
出版者	BAISHIDENG PUBLISHING GROUP INC
ISSN	1007-9327
EISSN	2219-2840
卷号	30 期号:1 页码:34-49
DOI	10.3748/wjg.v30.i1.34
页数	17
WOS类目	Gastroenterology & Hepatology
WOS研究方向	Gastroenterology & Hepatology
WOS记录号	WOS:001157325400002
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	38293325
SCOPUSEID	2-s2.0-85183725516
通讯作者地址	[Jin, Xi]Zhejiang Univ, Dept Gastroenterol, Affiliated Hosp 1, Sch Med, 79 Qingchun Rd, Hangzhou 310003, Zhejiang Provin, Peoples R China.
Scopus学科分类	Gastroenterology
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/206996
专题	附属第一医院_消化内科
通讯作者	Jin, Xi
作者单位	1.Zhejiang Univ, Dept Gastroenterol, Affiliated Hosp 1, Sch Med, Hangzhou 310003, Zhejiang, Peoples R China; 2.Second Hosp Jiaxing, Dept Gastroenterol, Jiaxing 314000, Zhejiang Provin, Peoples R China; 3.Zhejiang Univ, Endoscopy Ctr, Childrens Hosp, Sch Med, Hangzhou 310003, Zhejiang Provin, Peoples R China; 4.Second Peoples Hosp Yuhang Dist, Dept Gastroenterol, Hangzhou 310000, Zhejiang Provin, Peoples R China; 5.Hangzhou Shangcheng Dist Peoples Hosp, Dept Gastroenterol, Hangzhou 310003, Zhejiang Provin, Peoples R China; 6.Zhejiang Univ, Dept Colorectal Surg, Affiliated Hosp 1, Sch Med, Hangzhou 310003, Zhejiang Provin, Peoples R China; 7.Wenzhou Med Univ, Dept Gastroenterol, Affiliated Hosp 1, Wenzhou 325000, Zhejiang Provin, Peoples R China; 8.Zhejiang Univ, Womens Hosp, Inst Genet, Sch Med, Hangzhou 310000, Zhejiang Provin, Peoples R China; 9.Zhejiang Univ, Ctr Stem Cell & Regenerat Med, Bone Marrow Transplantat Ctr, Affiliated Hosp 1,Sch Med, Hangzhou 310003, Zhejiang Provin, Peoples R China; 10.Zhejiang Univ, Dept Infect Dis, Affiliated Hosp 1, Sch Med, Hangzhou 310003, Zhejiang, Peoples R China; 11.Zhejiang Univ, Dept Gastroenterol, Affiliated Hosp 1, Sch Med, 79 Qingchun Rd, Hangzhou 310003, Zhejiang Provin, Peoples R China
推荐引用方式 GB/T 7714	Zhou, Yu-Wei,Ren, Yue,Lu, Miao-Miao,et al. Crohn's disease as the intestinal manifestation of pan-lymphatic dysfunction: An exploratory proposal based on basic and clinical data[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2024,30(1):34-49.
APA	Zhou, Yu-Wei., Ren, Yue., Lu, Miao-Miao., Xu, Ling-Ling., Cheng, Wei-Xin., ... & Jin, Xi. (2024). Crohn's disease as the intestinal manifestation of pan-lymphatic dysfunction: An exploratory proposal based on basic and clinical data. WORLD JOURNAL OF GASTROENTEROLOGY, 30(1), 34-49.
MLA	Zhou, Yu-Wei,et al."Crohn's disease as the intestinal manifestation of pan-lymphatic dysfunction: An exploratory proposal based on basic and clinical data".WORLD JOURNAL OF GASTROENTEROLOGY 30.1(2024):34-49.